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. 1986 May;45(5):400–404. doi: 10.1136/ard.45.5.400

IgG subclass serum levels in juvenile chronic arthritis.

A Martini, A Plebani, A Ravelli, M A Avanzini, R Jefferis, L Zonta, L D Notarangelo, A G Ugazio, R Burgio
PMCID: PMC1001899  PMID: 3718013

Abstract

IgG subclass levels of sera from 26 patients with juvenile chronic arthritis (JCA) were determined by means of mouse monoclonal antibodies. Patients were divided into three groups according to clinical activity of the disease: active disease, partial remission, and remission. One hundred and sixty four age matched, healthy children served as controls. IgG subclass concentrations were log transformed, and a robust regression method was applied to obtain expected values for the different ages. We found a significant increase of IgG3 (p less than 0.0001), IgG1 (p less than 0.002), and IgG2 (p less than 0.035) in JCA sera, while IgG4 values did not differ significantly from those of controls. When patients were divided according to clinical activity significant increases of IgG2 and IgG4 were observed in the patients in partial remission. Our data suggest that differential increase of IgG subclasses during the courses of JCA may be of relevance to the pathogenesis of the disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bannister K. M., Howarth G. S., Clarkson A. R., Woodroffe A. J. Glomerular IgG subclass distribution in human glomerulonephritis. Clin Nephrol. 1983 Apr;19(4):161–165. [PubMed] [Google Scholar]
  2. Beck O. E. Distribution of virus antibody activity among human IgG subclasses. Clin Exp Immunol. 1981 Mar;43(3):626–632. [PMC free article] [PubMed] [Google Scholar]
  3. Brewer E. J., Jr, Bass J., Baum J., Cassidy J. T., Fink C., Jacobs J., Hanson V., Levinson J. E., Schaller J., Stillman J. S. Current proposed revision of JRA Criteria. JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Section of The Arthritis Foundation. Arthritis Rheum. 1977 Mar;20(2 Suppl):195–199. [PubMed] [Google Scholar]
  4. Cassidy J. T., Petty R. E., Sullivan D. B. Abnormalities in the distribution of serum immunoglobulin concentrations in juvenile rheumatoid arthritis. J Clin Invest. 1973 Aug;52(8):1931–1936. doi: 10.1172/JCI107377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Doi T., Mayumi M., Kanatsu K., Suehiro F., Hamashima Y. Distribution of IgG subclasses in membranous nephropathy. Clin Exp Immunol. 1984 Oct;58(1):57–62. [PMC free article] [PubMed] [Google Scholar]
  6. Garelli S., Mosconi L., Valbonesi M., Schieppati G., Navassa G. Plasma exchange for a hemolytic crisis due to autoimmune hemolytic anemia of the IgG warm type. Blut. 1980 Nov;41(5):387–391. doi: 10.1007/BF01035494. [DOI] [PubMed] [Google Scholar]
  7. Heiner D. C. Significance of immunoglobulin G subclasses. Am J Med. 1984 Mar 30;76(3A):1–6. doi: 10.1016/0002-9343(84)90313-9. [DOI] [PubMed] [Google Scholar]
  8. Hoffman W. L., Goldberg M. S., Smiley J. D. Immunoglobulin G3 subclass production by rheumatoid synovial tissue cultures. J Clin Invest. 1982 Jan;69(1):136–144. doi: 10.1172/JCI110424. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  10. Moore T. L., Osborn T. G., Weiss T. D., Sheridan P. W., Eisenwinter R. K., Miller A. V., Dorner R. W., Zuckner J. Autoantibodies in juvenile arthritis. Semin Arthritis Rheum. 1984 May;13(4):329–336. doi: 10.1016/0049-0172(84)90013-1. [DOI] [PubMed] [Google Scholar]
  11. Munthe E., Natvig J. B. Immunglobulin classes, subclasses and complexes of IgG rheumatoid factor in rheumatoid plasma cells. Clin Exp Immunol. 1972 Sep;12(1):55–70. [PMC free article] [PubMed] [Google Scholar]
  12. Oxelius V. A. Immunoglobulin G (IgG) subclasses and human disease. Am J Med. 1984 Mar 30;76(3A):7–18. doi: 10.1016/0002-9343(84)90314-0. [DOI] [PubMed] [Google Scholar]
  13. Pinals R. S., Masi A. T., Larsen R. A. Preliminary criteria for clinical remission in rheumatoid arthritis. Arthritis Rheum. 1981 Oct;24(10):1308–1315. doi: 10.1002/art.1780241012. [DOI] [PubMed] [Google Scholar]
  14. Riesen W. F., Skvaril F., Braun D. G. Natural infection of man with group A streptococci. Levels; restriction in class, subclass, and type; and clonal appearance of polysaccharide-group-specific antibodies. Scand J Immunol. 1976;5(4):383–390. doi: 10.1111/j.1365-3083.1976.tb00292.x. [DOI] [PubMed] [Google Scholar]
  15. Shakib F., Stanworth D. R. Human IgG subclasses in health and disease. (A review). Part I. Ric Clin Lab. 1980 Jul-Sep;10(3):463–479. doi: 10.1007/BF02938793. [DOI] [PubMed] [Google Scholar]
  16. Shakib F., Stanworth D. R. Human IgG subclasses in health and disease. (A review). Part II. Ric Clin Lab. 1980 Oct-Dec;10(4):561–580. doi: 10.1007/BF02906696. [DOI] [PubMed] [Google Scholar]
  17. Shakib F., Stanworth D. R. IgG subclass composition of rheumatoid arthritic sera and joint fluids. Ann Rheum Dis. 1976 Jun;35(3):263–266. doi: 10.1136/ard.35.3.263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. TERRY W. D., FAHEY J. L. SUBCLASSES OF HUMAN GAMMA-2-GLOBULIN BASED ON DIFFERENCES IN THE HEAVY POLYPEPTIDE CHAINS. Science. 1964 Oct 16;146(3642):400–401. doi: 10.1126/science.146.3642.400. [DOI] [PubMed] [Google Scholar]

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