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. 1986 Jun;45(6):502–507. doi: 10.1136/ard.45.6.502

A study of anti-poly (ADP-ribose) antibodies and an anti-DNA antibody idiotype and other immunological abnormalities in lupus family members.

C Dudeney, Y Shoenfeld, J Rauch, M Jones, C Mackworth Young, M Tavassoli, S Shall, D A Isenberg
PMCID: PMC1001923  PMID: 3488036

Abstract

The genetic background of systemic lupus erythematosus (SLE) has been reexamined in a study of the serum of 31 lupus patients and 80 asymptomatic first degree relatives by measuring a common, cross reacting anti-DNA antibody idiotype designated 134, antibodies to poly(ADP-ribose), serum C3, circulating immune complexes, and antinuclear antibodies (ANA). Over 30% of the relatives had raised 134 and anti-poly(ADP-ribose) levels, and 9% had ANA titres greater than 1/20. In contrast, only one relative had a low serum C3 level. These results confirm that immunogenetic abnormalities associated with the production of autoantibodies and particular idiotypes must exist amongst lupus relatives as well as the patients. The production of autoantibodies, however, is not necessarily matched to the clinical expression of SLE.

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Selected References

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  1. Block S. R., Winfield J. B., Lockshin M. D., D'Angelo W. A., Christian C. L. Studies of twins with systemic lupus erythematosus. A review of the literature and presentation of 12 additional sets. Am J Med. 1975 Oct;59(4):533–552. doi: 10.1016/0002-9343(75)90261-2. [DOI] [PubMed] [Google Scholar]
  2. Clayton A. L., Bernstein R. M., Tavassoli M., Shall S., Bunn C., Hughes G. R., Chantler S. M. Measurement of antibody to poly (adenosine diphosphate-ribose): its diagnostic value in systemic lupus erythematosus. Clin Exp Immunol. 1984 May;56(2):263–271. [PMC free article] [PubMed] [Google Scholar]
  3. Creighton W. D., Lambert P. H., Miescher P. A. Detection of antibodies and soluble antigen-antibody complexes by precipitation with polyethylene glycol. J Immunol. 1973 Oct;111(4):1219–1227. [PubMed] [Google Scholar]
  4. Elkon K. B., Walport M. J., Rynes R. I., Black C. M., Batchelor J. R., Hughes G. R. Circulating C1q binding immune complexes in relatives of patients with systemic lupus erythematosus. Arthritis Rheum. 1983 Jul;26(7):921–924. doi: 10.1002/art.1780260716. [DOI] [PubMed] [Google Scholar]
  5. Estes D., Christian C. L. The natural history of systemic lupus erythematosus by prospective analysis. Medicine (Baltimore) 1971 Mar;50(2):85–95. doi: 10.1097/00005792-197103000-00001. [DOI] [PubMed] [Google Scholar]
  6. Fedrick J. A., Pandey J. P., Chen Z., Fudenberg H. H., Ainsworth S. K., Dobson R. L. Gm allotypes in blacks with systemic lupus erythematosus. Hum Immunol. 1983 Oct;8(2):177–181. doi: 10.1016/0198-8859(83)90012-5. [DOI] [PubMed] [Google Scholar]
  7. Fielder A. H., Walport M. J., Batchelor J. R., Rynes R. I., Black C. M., Dodi I. A., Hughes G. R. Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility. Br Med J (Clin Res Ed) 1983 Feb 5;286(6363):425–428. doi: 10.1136/bmj.286.6363.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Halpern R., Davidson A., Lazo A., Solomon G., Lahita R., Diamond B. Familial systemic lupus erythematosus. Presence of a cross-reactive idiotype in healthy family members. J Clin Invest. 1985 Aug;76(2):731–736. doi: 10.1172/JCI112028. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hiernaux J., Bona C. A. Shared idiotypes among monoclonal antibodies specific for different immunodominant sugars of lipopolysaccharide of different Gram-negative bacteria. Proc Natl Acad Sci U S A. 1982 Mar;79(5):1616–1620. doi: 10.1073/pnas.79.5.1616. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Isenberg D. A., Shoenfeld Y., Walport M., Mackworth-Young C., Dudeney C., Todd-Pokropek A., Brill S., Weinberger A., Pinkas J. Detection of cross-reactive anti-DNA antibody idiotypes in the serum of systemic lupus erythematosus patients and of their relatives. Arthritis Rheum. 1985 Sep;28(9):999–1007. doi: 10.1002/art.1780280907. [DOI] [PubMed] [Google Scholar]
  11. Kanai Y., Kawaminami Y., Miwa M., Matsushima T., Sugimura T. Naturally-occurring antibodies to poly(ADP-ribose) in patients with systemic lupus erythematosus. Nature. 1977 Jan 13;265(5590):175–177. doi: 10.1038/265175a0. [DOI] [PubMed] [Google Scholar]
  12. Karol R., Reichlin M., Noble R. W. Idiotypic cross-reactivity between antibodies of different specificities. J Exp Med. 1978 Dec 1;148(6):1488–1497. doi: 10.1084/jem.148.6.1488. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kidwell W. R., Mage M. G. Changes in poly(adenosine diphosphate-ribose) and poly(adenosine diphosphate-ribose) polymerase in synchronous HeLa cells. Biochemistry. 1976 Mar 23;15(6):1213–1217. doi: 10.1021/bi00651a006. [DOI] [PubMed] [Google Scholar]
  14. Lehman T. J., Curd J. G., Zvaifler N. J., Hanson V. The association of antinuclear antibodies, antilymphocyte antibodies, and C4 activation among the relatives of children with systemic lupus erythematosus. Arthritis Rheum. 1982 May;25(5):556–561. doi: 10.1002/art.1780250510. [DOI] [PubMed] [Google Scholar]
  15. MORTEO O. G., FRANKLIN E. C., MCEWEN C., PHYTHYON J., TANNER M. Studies of relatives of patients with systemic lupus erythematosus. Arthritis Rheum. 1961 Aug;4:356–363. doi: 10.1002/art.1780040404. [DOI] [PubMed] [Google Scholar]
  16. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  17. Messner R. P., De Horatius R., Ferrone S. Lymphocytotoxic antibodies in systemic lupus erythematosus patients and their relatives: reactivity with the HLA antigenic molecular complex. Arthritis Rheum. 1980 Mar;23(3):265–272. doi: 10.1002/art.1780230301. [DOI] [PubMed] [Google Scholar]
  18. Miller K. B., Schwartz R. S. Familial abnormalities of suppressor-cell function in systemic lupus erythematosus. N Engl J Med. 1979 Oct 11;301(15):803–809. doi: 10.1056/NEJM197910113011502. [DOI] [PubMed] [Google Scholar]
  19. Morrow W. J., Isenberg D. A., Parry H. F., Shen L., Okolie E. E., Farzaneh F., Shall S., Snaith M. L. Studies on autoantibodies to poly (adenosine diphosphate-ribose) in SLE and other autoimmune diseases. Ann Rheum Dis. 1982 Aug;41(4):396–402. doi: 10.1136/ard.41.4.396. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Okolie E. E., Shall S. The significance of antibodies to poly(adenosine diphosphate-ribose) in systemic lupus erythematosus. Clin Exp Immunol. 1979 Apr;36(1):151–164. [PMC free article] [PubMed] [Google Scholar]
  21. Poulton T. A., Crowther M. E., Hay F. C., Nineham L. J. Immune complexes in ovarian cancer. Lancet. 1978 Jul 8;2(8080):72–73. doi: 10.1016/s0140-6736(78)91383-1. [DOI] [PubMed] [Google Scholar]
  22. Rajewsky K., Takemori T. Genetics, expression, and function of idiotypes. Annu Rev Immunol. 1983;1:569–607. doi: 10.1146/annurev.iy.01.040183.003033. [DOI] [PubMed] [Google Scholar]
  23. Rauch J., Massicotte H., Wild J., Tannenbaum H. Sensitive solid phase radioimmunoassay for the detection of anti-DNA autoantibodies. J Rheumatol. 1985 Jun;12(3):482–486. [PubMed] [Google Scholar]
  24. Rynes R. I. Inherited complement deficiency states and SLE. Clin Rheum Dis. 1982 Apr;8(1):29–47. [PubMed] [Google Scholar]
  25. Shoenfeld Y., Hsu-Lin S. C., Gabriels J. E., Silberstein L. E., Furie B. C., Furie B., Stollar B. D., Schwartz R. S. Production of autoantibodies by human-human hybridomas. J Clin Invest. 1982 Jul;70(1):205–208. doi: 10.1172/JCI110595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Shoenfeld Y., Isenberg D. A., Rauch J., Madaio M. P., Stollar B. D., Schwartz R. S. Idiotypic cross-reactions of monoclonal human lupus autoantibodies. J Exp Med. 1983 Sep 1;158(3):718–730. doi: 10.1084/jem.158.3.718. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Shoenfeld Y., Rauch J., Massicotte H., Datta S. K., André-Schwartz J., Stollar B. D., Schwartz R. S. Polyspecificity of monoclonal lupus autoantibodies produced by human-human hybridomas. N Engl J Med. 1983 Feb 24;308(8):414–420. doi: 10.1056/NEJM198302243080802. [DOI] [PubMed] [Google Scholar]
  28. Shoenfeld Y., Schwartz R. S. Immunologic and genetic factors in autoimmune diseases. N Engl J Med. 1984 Oct 18;311(16):1019–1029. doi: 10.1056/NEJM198410183111605. [DOI] [PubMed] [Google Scholar]
  29. Siegel M., Holley H. L., Lee S. L. Epidemiologic studies on systemic lupus erythematosus. Comparative data for New York City and Jefferson County, Alabama, 1956-1965. Arthritis Rheum. 1970 Nov-Dec;13(6):802–811. doi: 10.1002/art.1780130610. [DOI] [PubMed] [Google Scholar]
  30. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
  31. Theofilopoulos A. N., Balderas R. S., Gozes Y., Aguado M. T., Hang L. M., Morrow P. R., Dixon F. J. Association of lpr gene with graft-vs.-host disease-like syndrome. J Exp Med. 1985 Jul 1;162(1):1–18. doi: 10.1084/jem.162.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Walport M. J., Black C. M., Batchelor J. R. The immunogenetics of SLE. Clin Rheum Dis. 1982 Apr;8(1):3–21. [PubMed] [Google Scholar]

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