Abstract
Patients who develop reactive arthritis after yersinia enteritis are characterised by high and persisting IgA-anti-yersinia antibodies. We have further analysed the humoral immune response to yersinia in this condition. Total concentrations of IgM, IgG, IgA, and secretory IgA in the serum and specific anti-yersinia antibodies belonging to IgA1, IgA2, or secretory IgA were compared in patients with or without reactive arthritis. In the former group the serum concentration of secretory IgA and of yersinia specific antibodies in all categories studied was raised compared with the level in patients without joint symptoms; the difference was most significant for the IgA-anti-yersinia antibodies with secretory piece or with J chain. The findings suggest that the strong antibody response in the patients developing reactive arthritis is due to a chronic stimulation of the intestinal lymphoid tissue.
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Selected References
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- Ahlqvist J., Ahvonen P., Räsänen J. A., Wallgren G. R. Enteric infection with Yersinia enterocolitica. Large pyroninophilic cell reaction in mesenteric lymph nodes associated with early production of specific antibodies. Acta Pathol Microbiol Scand A. 1971;79(2):109–122. [PubMed] [Google Scholar]
- Aho K., Ahvonen P., Lassus A., Sievers K., Tiilikainen A. HL-A 27 in reactive arthritis. A study of Yersinia arthritis and Reiter's disease. Arthritis Rheum. 1974 Sep-Oct;17(5):521–526. doi: 10.1002/art.1780170505. [DOI] [PubMed] [Google Scholar]
- André C., André F., Fargier C. Distribution of IgA 1 and IgA 2 plasma cells in various normal human tissues and in the jejunum of plasma IgA-deficient patients. Clin Exp Immunol. 1978 Aug;33(2):327–331. [PMC free article] [PubMed] [Google Scholar]
- André C., Berthoux F. C., André F., Gillon J., Genin C., Sabatier J. C. Prevalence of IgA2 deposits in IgA nephropathies: a clue to their pathogenesis. N Engl J Med. 1980 Dec 4;303(23):1343–1346. doi: 10.1056/NEJM198012043032306. [DOI] [PubMed] [Google Scholar]
- Brandtzaeg P., Prydz H. Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins. Nature. 1984 Sep 6;311(5981):71–73. doi: 10.1038/311071a0. [DOI] [PubMed] [Google Scholar]
- Brown T. A., Murphy B. R., Radl J., Haaijman J. J., Mestecky J. Subclass distribution and molecular form of immunoglobulin A hemagglutinin antibodies in sera and nasal secretions after experimental secondary infection with influenza A virus in humans. J Clin Microbiol. 1985 Aug;22(2):259–264. doi: 10.1128/jcm.22.2.259-264.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Calguneri M., Swinburne L., Shinebaum R., Cooke E. M., Wright V. Secretory IgA: immune defence pattern in ankylosing spondylitis and klebsiella. Ann Rheum Dis. 1981 Dec;40(6):600–604. doi: 10.1136/ard.40.6.600. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cowling P., Ebringer R., Ebringer A. Association of inflammation with raised serum IgA in ankylosing spondylitis. Ann Rheum Dis. 1980 Dec;39(6):545–549. doi: 10.1136/ard.39.6.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Crago S. S., Kutteh W. H., Moro I., Allansmith M. R., Radl J., Haaijman J. J., Mestecky J. Distribution of IgA1-, IgA2-, and J chain-containing cells in human tissues. J Immunol. 1984 Jan;132(1):16–18. [PubMed] [Google Scholar]
- Delacroix D. L., Dive C., Rambaud J. C., Vaerman J. P. IgA subclasses in various secretions and in serum. Immunology. 1982 Oct;47(2):383–385. [PMC free article] [PubMed] [Google Scholar]
- Diagnosis of human brucellosis with ELISA. Lancet. 1982 Sep 18;2(8299):668–668. [PubMed] [Google Scholar]
- Granfors K. Measurement of immunoglobulin M (IgM), IgG, and IgA antibodies against Yersinia enterocolitica by enzyme-linked immunosorbent assay: persistence of serum antibodies during disease. J Clin Microbiol. 1979 Mar;9(3):336–341. doi: 10.1128/jcm.9.3.336-341.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Granfors K., Viljanen M. K., Toivanen A. Measurement of immunoglobulin M, immunoglobulin G, and immunoglobulin A antibodies against Yersinia enterocolitica by enzyme-linked immunosorbent assay: comparison of lipopolysaccharide and whole bacterium as antigen. J Clin Microbiol. 1981 Jul;14(1):6–14. doi: 10.1128/jcm.14.1.6-14.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Granfors K., Viljanen M., Tiilikainen A., Toivanen A. Persistence of IgM, IgG, and IgA antibodies to Yersinia in yersinia arthritis. J Infect Dis. 1980 Apr;141(4):424–429. doi: 10.1093/infdis/141.4.424. [DOI] [PubMed] [Google Scholar]
- Griffiss J. M. Bactericidal activity of meningococcal antisera. Blocking by IgA of lytic antibody in human convalescent sera. J Immunol. 1975 Jun;114(6):1779–1784. [PubMed] [Google Scholar]
- Hall W. H., Manion R. E., Zinneman H. H. Blocking serum lysis of Brucella abortus by hyperimmune rabbit immunoglubulin A. J Immunol. 1971 Jul;107(1):41–46. [PubMed] [Google Scholar]
- Kalliomäki J. L., Leino R. Follow-up studies of joint complications in yersiniosis. Acta Med Scand. 1979;205(6):521–525. doi: 10.1111/j.0954-6820.1979.tb06095.x. [DOI] [PubMed] [Google Scholar]
- Keat A. Reiter's syndrome and reactive arthritis in perspective. N Engl J Med. 1983 Dec 29;309(26):1606–1615. doi: 10.1056/NEJM198312293092604. [DOI] [PubMed] [Google Scholar]
- Leino R., Kalliomäki J. L. Yersiniosis as an internal disease. Ann Intern Med. 1974 Oct;81(4):458–461. doi: 10.7326/0003-4819-81-4-458. [DOI] [PubMed] [Google Scholar]
- Leino R., Vuento R., Koskimies S., Viander M., Toivanen A. Depressed lymphocyte transformation by yersinia and Escherichia coli in yersinia arthritis. Ann Rheum Dis. 1983 Apr;42(2):176–181. doi: 10.1136/ard.42.2.176. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leirisalo M., Skylv G., Kousa M., Voipio-Pulkki L. M., Suoranta H., Nissilä M., Hvidman L., Nielsen E. D., Svejgaard A., Tilikainen A. Followup study on patients with Reiter's disease and reactive arthritis, with special reference to HLA-B27. Arthritis Rheum. 1982 Mar;25(3):249–259. doi: 10.1002/art.1780250302. [DOI] [PubMed] [Google Scholar]
- Liyanage S. P., Currey H. L., Vernon-Roberts B. Influence of tubercle aggregate size on severity of adjuvant arthritis in the rat. Ann Rheum Dis. 1975 Feb;34(1):49–53. doi: 10.1136/ard.34.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mattila L., Granfors K., Toivanen A. Acute anterior uveitis after yersinia infection. Br J Ophthalmol. 1982 Mar;66(3):209–212. doi: 10.1136/bjo.66.3.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Teitsson I., Withrington R. H., Seifert M. H., Valdimarsson H. Prospective study of early rheumatoid arthritis. I. Prognostic value of IgA rheumatoid factor. Ann Rheum Dis. 1984 Oct;43(5):673–678. doi: 10.1136/ard.43.5.673. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tertti R., Granfors K., Lehtonen O. P., Mertsola J., Mäkelä A. L., Välimäki I., Hänninen P., Toivanen A. An outbreak of Yersinia pseudotuberculosis infection. J Infect Dis. 1984 Feb;149(2):245–250. doi: 10.1093/infdis/149.2.245. [DOI] [PubMed] [Google Scholar]
- Toivanen P., Toivanen A., Olkkonen L., Aantaa S. Hospital outbreak of Yersinia enterocolitica infection. Lancet. 1973 Apr 14;1(7807):801–803. doi: 10.1016/s0140-6736(73)90601-6. [DOI] [PubMed] [Google Scholar]
- Trull A. K., Ebringer R., Panayi G. S., Colthorpe D., James D. C., Ebringer A. IgA antibodies to Klebsiella pneumoniae in ankylosing spondylitis. Scand J Rheumatol. 1983;12(3):249–253. doi: 10.3109/03009748309098543. [DOI] [PubMed] [Google Scholar]
- Trull A. K., Panayi G. S. Serum and secretory IgA immune response to Klebsiella pneumoniae in ankylosing spondylitis. Clin Rheumatol. 1983 Dec;2(4):331–337. doi: 10.1007/BF02041551. [DOI] [PubMed] [Google Scholar]
- Vuento R., Eskola J., Leino R., Koskimies S., Viander M. IgM, IgG, and IgA synthesis in vitro in persons suffering from yersinia arthritis and in patients with ankylosing spondylitis. Ann Rheum Dis. 1984 Apr;43(2):186–191. doi: 10.1136/ard.43.2.186. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vuento R., Leino R., Viander M., Toivanen A. In vitro lymphoproliferative response to Yersinia: depressed response in arthritic patients years after Yersinia infection. Clin Exp Rheumatol. 1983 Jul-Sep;1(3):219–224. [PubMed] [Google Scholar]
- Vuento R., Leino R., Viander M., Toivanen A. Lymphocyte transformation responses to gram negative bacteria after Yersinia and Salmonella infection: the importance of enterobacterial common antigen for the response. J Rheumatol. 1984 Jun;11(3):369–372. [PubMed] [Google Scholar]
- Withrington R. H., Teitsson I., Valdimarsson H., Seifert M. H. Prospective study of early rheumatoid arthritis. II. Association of rheumatoid factor isotypes with fluctuations in disease activity. Ann Rheum Dis. 1984 Oct;43(5):679–685. doi: 10.1136/ard.43.5.679. [DOI] [PMC free article] [PubMed] [Google Scholar]