Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1986 Nov;45(11):945–949. doi: 10.1136/ard.45.11.945

Prediction of progressive joint damage in patients with rheumatoid arthritis receiving gold or D-penicillamine therapy.

P T Dawes, P D Fowler, R Jackson, M Collins, M F Shadforth, R Stone, D L Scott
PMCID: PMC1002025  PMID: 3539037

Abstract

Seventy two patients with classical or definite rheumatoid arthritis (RA) were randomly allocated to receive gold or D-penicillamine therapy (DPA) in a prospective study designed to evaluate whether it is possible to predict which patients will show radiological progression despite therapy. Forty five patients completed 12 months' treatment. There were no significant demographic or clinical differences between them and the 27 drop outs. Twenty of the 45 patients showed no radiological progression between six and 12 months. These patients had less severe initial radiological damage, lower levels of serum aspartate transaminase (serum AST) and lactic dehydrogenase (LDH), but higher levels of serum cholesterol. Twenty five patients did show progression during the six to 12 month period. This group included all the men with nodules. Of the 43 pretreatment clinical and laboratory variables examined, however, the majority failed to predict whether or not progression would subsequently occur. This included the acute phase response and seropositivity.

Full text

PDF
945

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amos R. S., Constable T. J., Crockson R. A., Crockson A. P., McConkey B. Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes. Br Med J. 1977 Jan 22;1(6055):195–197. doi: 10.1136/bmj.1.6055.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BLAND J. H., BROWN E. W. SERONEGATIVE AND SEROPOSITIVE RHEUMATOID ARTHRITIS: CLINICAL, RADIOLOGICAL, AND BIOCHEMICAL DIFFERENCES. Ann Intern Med. 1964 Jan;60:88–94. doi: 10.7326/0003-4819-60-1-88. [DOI] [PubMed] [Google Scholar]
  3. Burns T. M., Calin A. The hand radiograph as a diagnostic discriminant between seropositive and seronegative 'rheumatoid arthritis': a controlled study. Ann Rheum Dis. 1983 Dec;42(6):605–612. doi: 10.1136/ard.42.6.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dawes P. T., Fowler P. D., Clarke S., Fisher J., Lawton A., Shadforth M. F. Rheumatoid arthritis: treatment which controls the C-reactive protein and erythrocyte sedimentation rate reduces radiological progression. Br J Rheumatol. 1986 Feb;25(1):44–49. doi: 10.1093/rheumatology/25.1.44. [DOI] [PubMed] [Google Scholar]
  5. Fernandes L., Sullivan S., McFarlane I. G., Wojcicka B. M., Warnes T. W., Eddleston A. L., Hamilton E. B., Williams R. Studies on the frequency and pathogenesis of liver involvement in rheumatoid arthritis. Ann Rheum Dis. 1979 Dec;38(6):501–506. doi: 10.1136/ard.38.6.501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gofton J. P. Problems associated with the measurement of radiologic progression of disease in rheumatoid arthritis. J Rheumatol. 1983 Apr;10(2):177–179. [PubMed] [Google Scholar]
  7. Hart F. D. Presentation of rheumatoid arthritis and its relation to prognosis. Br Med J. 1977 Sep 3;2(6087):621–624. doi: 10.1136/bmj.2.6087.621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Iannuzzi L., Dawson N., Zein N., Kushner I. Does drug therapy slow radiographic deterioration in rheumatoid arthritis? N Engl J Med. 1983 Oct 27;309(17):1023–1028. doi: 10.1056/NEJM198310273091704. [DOI] [PubMed] [Google Scholar]
  9. Kirwan J. R., Currey H. L. Rheumatoid arthritis: disease-modifying antirheumatic drugs. Clin Rheum Dis. 1983 Dec;9(3):581–599. [PubMed] [Google Scholar]
  10. Larsen A., Dale K., Eek M. Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diagn (Stockh) 1977 Jul;18(4):481–491. doi: 10.1177/028418517701800415. [DOI] [PubMed] [Google Scholar]
  11. Luukkainen R., Isomäki H., Kajander A. Effect of gold treatment on the progression of erosions in RA patients. Scand J Rheumatol. 1977;6(2):123–127. doi: 10.3109/03009747709095434. [DOI] [PubMed] [Google Scholar]
  12. Masi A. T., Maldonado-Cocco J. A., Kaplan S. B., Feigenbaum S. L., Chandler R. W. Prospective study of the early course of rheumatoid arthritis in young adults: comparison of patients with and without rheumatoid factor positivity at entry and identification of variables correlating with outcome. Semin Arthritis Rheum. 1976 May;4(4):299–326. doi: 10.1016/0049-0172(76)90013-5. [DOI] [PubMed] [Google Scholar]
  13. McCarty D. J., Carrera G. F. Intractable rheumatoid arthritis. Treatment with combined cyclophosphamide, azathioprine, and hydroxychloroquine. JAMA. 1982 Oct 8;248(14):1718–1723. doi: 10.1001/jama.248.14.1718. [DOI] [PubMed] [Google Scholar]
  14. Ochi T., Yonemasu K., Iwase R., Sasaki T., Tsuyama K., Ono K. Serum C1q levels as a prognostic guide to articular erosions in patients with rheumatoid arthritis. Arthritis Rheum. 1984 Aug;27(8):883–887. doi: 10.1002/art.1780270807. [DOI] [PubMed] [Google Scholar]
  15. Panayi G. S. Does rheumatoid arthritis have a clinicopathological spectrum similar to that of leprosy? Ann Rheum Dis. 1982 Feb;41(1):102–103. doi: 10.1136/ard.41.1.102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Pullar T., Hunter J. A., Capell H. A. Does second-line therapy affect the radiological progression of rheumatoid arthritis? Ann Rheum Dis. 1984 Feb;43(1):18–23. doi: 10.1136/ard.43.1.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Scott D. L., Dawes P. T., Fowler P. D., Grindulis K. A., Shadforth M., Bacon P. A. Anti-rheumatic drugs and joint damage in rheumatoid arthritis. Q J Med. 1985 Jan;54(213):49–59. [PubMed] [Google Scholar]
  18. Sharp J. T., Lidsky M. D., Duffy J. Clinical responses during gold therapy for rheumatoid arthritis. Changes in synovitis, radiologically detectable erosive lesions, serum proteins, and serologic abnormalities. Arthritis Rheum. 1982 May;25(5):540–549. doi: 10.1002/art.1780250508. [DOI] [PubMed] [Google Scholar]
  19. Sjöblom K. G., Saxne T., Pettersson H., Wollheim F. A. Factors related to the progression of joint destruction in rheumatoid arthritis. Scand J Rheumatol. 1984;13(1):21–27. doi: 10.3109/03009748409102663. [DOI] [PubMed] [Google Scholar]
  20. Withrington R. H., Seifert M. H. Predominant wrist disease in rheumatoid arthritis associated with high concentration of IgA rheumatoid factor. Br Med J (Clin Res Ed) 1985 Nov 16;291(6506):1388–1388. doi: 10.1136/bmj.291.6506.1388. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES