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. 1987 Apr;46(4):273–276. doi: 10.1136/ard.46.4.273

Correlation of immunoglobulin and C reactive protein levels in ankylosing spondylitis and rheumatoid arthritis.

K M Sanders, A Hertzman, M R Escobar, B H Littman
PMCID: PMC1002118  PMID: 3592781

Abstract

Serum C reactive protein (CRP), IgG, and IgA levels were measured in 22 patients with ankylosing spondylitis (AS) and in 20 patients with rheumatoid arthritis (RA) to study the regulation of these proteins in inflammatory disease states. In both RA and AS the mean CRP, IgG, and IgA levels were raised above normal values. Although IgA and CRP levels showed a significant positive correlation in RA (r = 0.53, p = 0.02), there was no correlation between these values in AS (r = 0.24, p = 0.29). The difference in correlation coefficients between the AS and RA groups was significant at a p = 0.05 level. In RA the raised IgA levels may be another manifestation of the acute phase response, as shown by the good correlation between IgA and CRP in that disease. In AS, however, the IgA levels, although raised, do not correlate with CRP levels, suggesting that the mechanism of increase of IgA in the two diseases is different. Gut mediated immune stimulation has been proposed as a cause of raised IgA levels in AS.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ammann A. J., Hong R. Selective IgA deficiency: presentation of 30 cases and a review of the literature. Medicine (Baltimore) 1971 May;50(3):223–236. [PubMed] [Google Scholar]
  2. Amos R. S., Constable T. J., Crockson R. A., Crockson A. P., McConkey B. Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes. Br Med J. 1977 Jan 22;1(6055):195–197. doi: 10.1136/bmj.1.6055.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Calguneri M., Swinburne L., Shinebaum R., Cooke E. M., Wright V. Secretory IgA: immune defence pattern in ankylosing spondylitis and klebsiella. Ann Rheum Dis. 1981 Dec;40(6):600–604. doi: 10.1136/ard.40.6.600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Claus D. R., Osmand A. P., Gewurz H. Radioimmunoassay of human C-reactive protein and levels in normal sera. J Lab Clin Med. 1976 Jan;87(1):120–128. [PubMed] [Google Scholar]
  5. Cowling P., Ebringer R., Cawdell D., Ishii M., Ebringer A. C-reactive protein, ESR, and klebsiella in ankylosing spondylitis. Ann Rheum Dis. 1980 Feb;39(1):45–49. doi: 10.1136/ard.39.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cowling P., Ebringer R., Ebringer A. Association of inflammation with raised serum IgA in ankylosing spondylitis. Ann Rheum Dis. 1980 Dec;39(6):545–549. doi: 10.1136/ard.39.6.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Deicher H., Ebringer A., Hildebrand S., Kemper A., Zeidler H. Circulating immune complexes in ankylosing spondylitis. Br J Rheumatol. 1983 Nov;22(4 Suppl 2):122–127. doi: 10.1093/rheumatology/xxii.suppl_2.122. [DOI] [PubMed] [Google Scholar]
  8. Doe W. F. An overview of intestinal immunity and malabsorption. Am J Med. 1979 Dec;67(6):1077–1084. doi: 10.1016/0002-9343(79)90650-8. [DOI] [PubMed] [Google Scholar]
  9. Ebringer R. W., Cawdell D. R., Cowling P., Ebringer A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis. 1978 Apr;37(2):146–151. doi: 10.1136/ard.37.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Franssen M. J., van de Putte L. B., Gribnau F. W. IgA serum levels and disease activity in ankylosing spondylitis: a prospective study. Ann Rheum Dis. 1985 Nov;44(11):766–771. doi: 10.1136/ard.44.11.766. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Good A. E., Cassidy J. T., Mutchnick M. G., Reed R. E., Lederman H. M. Ankylosing spondylitis with selective IgA deficiency and a circulating anticoagulant. J Rheumatol. 1977 Autumn;4(3):297–302. [PubMed] [Google Scholar]
  12. Keat A. Reiter's syndrome and reactive arthritis in perspective. N Engl J Med. 1983 Dec 29;309(26):1606–1615. doi: 10.1056/NEJM198312293092604. [DOI] [PubMed] [Google Scholar]
  13. Kinsella T. D., Espinoza L., Vasey F. B. Serum complement and immunoglobulin levels in sporadic and familial ankylosing spondylitis. J Rheumatol. 1975 Sep;2(3):308–313. [PubMed] [Google Scholar]
  14. Laurent M. R., Panayi G. S. Acute-phase proteins and serum immunoglobulins in ankylosing spondylitis. Ann Rheum Dis. 1983 Oct;42(5):524–528. doi: 10.1136/ard.42.5.524. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Mallya R. K., de Beer F. C., Berry H., Hamilton E. D., Mace B. E., Pepys M. B. Correlation of clinical parameters of disease activity in rheumatoid arthritis with serum concentration of C-reactive protein and erythrocyte sedimentation rate. J Rheumatol. 1982 Mar-Apr;9(2):224–228. [PubMed] [Google Scholar]
  16. McConkey B., Crockson R. A., Crockson A. P. The assessment of rheumatoid arthritis. A study based on measurements of the serum acute-phase reactants. Q J Med. 1972 Apr;41(162):115–125. [PubMed] [Google Scholar]
  17. McConkey B., Crockson R. A., Crockson A. P., Wilkinson A. R. The effects of some anti-inflammatory drugs on the acute-phase proteins in rheumatoid arthritis. Q J Med. 1973 Oct;42(168):785–791. [PubMed] [Google Scholar]
  18. Nashel D. J., Petrone D. L., Ulmer C. C., Sliwinski A. J. C-reactive protein: a marker for disease activity in ankylosing spondylitis and Reiter's syndrome. J Rheumatol. 1986 Apr;13(2):364–367. [PubMed] [Google Scholar]
  19. Pruzanski W., Russell M. L., Gordon D. A., Ogryzlo M. A. Serum and synovial fluid proteins in rheumatoid arthritis and degenerative joint diseases. Am J Med Sci. 1973 Jun;265(6):483–490. doi: 10.1097/00000441-197306000-00007. [DOI] [PubMed] [Google Scholar]
  20. Scott D. G., Ring E. F., Bacon P. A. Problems in the assessment of disease activity in ankylosing spondylitis. Rheumatol Rehabil. 1981 May;20(2):74–80. doi: 10.1093/rheumatology/20.2.74. [DOI] [PubMed] [Google Scholar]
  21. Smith M. D., Gibson R. A., Brooks P. M. Abnormal bowel permeability in ankylosing spondylitis and rheumatoid arthritis. J Rheumatol. 1985 Apr;12(2):299–305. [PubMed] [Google Scholar]
  22. Tosato G., Steinberg A. D., Blaese R. M. Defective EBV-specific suppressor T-cell function in rheumatoid arthritis. N Engl J Med. 1981 Nov 19;305(21):1238–1243. doi: 10.1056/NEJM198111193052102. [DOI] [PubMed] [Google Scholar]
  23. Trull A. K., Ebringer R., Panayi G. S., Colthorpe D., James D. C., Ebringer A. IgA antibodies to Klebsiella pneumoniae in ankylosing spondylitis. Scand J Rheumatol. 1983;12(3):249–253. doi: 10.3109/03009748309098543. [DOI] [PubMed] [Google Scholar]
  24. Veys E. M., Claessens H. E. Serum levels of IgG, IgM, and IgA in rheumatoid arthritis. Ann Rheum Dis. 1968 Sep;27(5):431–440. doi: 10.1136/ard.27.5.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Veys E. M., van Leare M. Serum IgG, IgM, and IgA levels in ankylosing spondylitis. Ann Rheum Dis. 1973 Nov;32(6):493–496. doi: 10.1136/ard.32.6.493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Walsh L., Davies P., McConkey B. Relationship between erythrocyte sedimentation rate and serum C-reactive protein in rheumatoid arthritis. Ann Rheum Dis. 1979 Aug;38(4):362–363. doi: 10.1136/ard.38.4.362. [DOI] [PMC free article] [PubMed] [Google Scholar]

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