Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1987 May;46(5):370–374. doi: 10.1136/ard.46.5.370

Vitamin D metabolites in synovial fluid.

A Fairney, A M Straffen, C May, M H Seifert
PMCID: PMC1002143  PMID: 3496056

Abstract

This study has shown that it is possible to measure vitamin D metabolites and vitamin D binding protein (DBP) in synovial fluid as well as serum. Significant amounts of 25-OHD, 24,25-(OH)2D, and DBP are present in synovial fluid. The 25-OHD and DBP maintain a serum:synovial fluid ratio of approximately 2:1 irrespective of the type of joint disease, whereas no such relationship was detected for 24,25-(OH)2D. The possible reasons for these findings are diffusion of the metabolites into synovial fluid or local production from suitable precursors, or both.

Full text

PDF
370

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bird H. A., Peacock M., Storer J. H., Wright V. Comparison of serum 25-OH vitamin D concentrations in rheumatoid arthritis and osteoarthrosis. Br Med J. 1980 Jun 14;280(6229):1416–1416. doi: 10.1136/bmj.280.6229.1416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bird H. A., Wright V., Hennes U., Theiss E. Comparison of serum 1,25-dihydroxycholecalciferol concentrations in rheumatoid arthritis and osteoarthrosis. Ann Rheum Dis. 1982 Jun;41(3):257–258. doi: 10.1136/ard.41.3.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dieppe P. A., Crocker P., Huskisson E. C., Willoughby D. A. Apatite deposition disease. A new arthropathy. Lancet. 1976 Feb 7;1(7954):266–269. doi: 10.1016/s0140-6736(76)91400-8. [DOI] [PubMed] [Google Scholar]
  4. Dunham J., Bourke B. E., Bitensky L., Chayen J., Loveridge N., Scott J. T. Circulating levels of biologically active parathyroid hormone in rheumatic diseases. Ann Rheum Dis. 1982 Dec;41(6):569–573. doi: 10.1136/ard.41.6.569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fairney A., Turner C., Hanson S., Zambon M. A simple micromethod for 25-hydroxyvitamin D estimation. Ann Clin Biochem. 1979 Mar;16(2):106–110. doi: 10.1177/000456327901600121. [DOI] [PubMed] [Google Scholar]
  6. Garabedian M., Lieberherr M., N'Guyen T. M., Corvol M. T., Du Bois M. B., Balsan S. The in vitro production and activity of 24, 25-dihydroxycholecalciferol in cartilage and calvarium. Clin Orthop Relat Res. 1978 Sep;(135):241–248. [PubMed] [Google Scholar]
  7. Mawer E. B. Clinical implications of measurements of circulating vitamin D metabolites. Clin Endocrinol Metab. 1980 Mar;9(1):63–79. doi: 10.1016/s0300-595x(80)80021-1. [DOI] [PubMed] [Google Scholar]
  8. Nuki G. Apatite associated arthritis. Br J Rheumatol. 1984 May;23(2):81–83. doi: 10.1093/rheumatology/23.2.81. [DOI] [PubMed] [Google Scholar]
  9. OGSTON A. G., PHELPS C. F. The partition of solutes between buffer solutions and solutions containing hyaluronic acid. Biochem J. 1961 Apr;78:827–833. doi: 10.1042/bj0780827. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Phelps P., Hawker C. D. Serum parathyroid hormone levels in patients with calcium pyrophosphate crystal deposition disease (chondrocalcinosis, pseudogout). Arthritis Rheum. 1973 Sep-Oct;16(5):590–596. doi: 10.1002/art.1780160503. [DOI] [PubMed] [Google Scholar]
  11. Pritchard M. H., Jessop J. D. Chondrocalcinosis in primary hyperparathyroidism. Influence of age, metabolic bone disease, and parathyroidectomy. Ann Rheum Dis. 1977 Apr;36(2):146–151. doi: 10.1136/ard.36.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES