Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1987 May;46(5):395–397. doi: 10.1136/ard.46.5.395

HLA haplotypes in non-familial rheumatoid arthritis.

L Legrand, G M Lathrop, T Bardin, A Marcelli-Barge, A Dryll, N Debeyre, A Ryckewaert
PMCID: PMC1002148  PMID: 3592801

Abstract

The frequencies of HLA-A, B, C, DR, and BF haplotypes in 44 unrelated Caucasian patients with definite seropositive rheumatoid arthritis (RA) were compared with haplotype frequencies in controls. Overall, the patients had an increased risk for HLA-DR4, DR3, and DR2 antigens, but frequencies of certain DR4 or DR3 haplotypes were not increased, suggesting the importance of other HLA loci for the evaluation of risk. The presence of DR4 alone was not found to produce an increased risk for RA since the frequencies of certain DR4 haplotypes were similar in patients and controls. Increased frequencies of HLA-B18, DR4, HLA-B15, DR4, and HLA-A1, B8, Cw7, DR3 haplotypes were found in patients. RA susceptibility has been found to be associated with the last two haplotypes in some studies of multiple case families, suggesting that similar genetic mechanisms may underlie the disease in familial and sporadic forms.

Full text

PDF
395

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alper C. A., Boenisch T., Watson L. Genetic polymorphism in human glycine-rich beta-glycoprotein. J Exp Med. 1972 Jan;135(1):68–80. doi: 10.1084/jem.135.1.68. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bardin T., Dryll A., Debeyre N., Ryckewaert A., Legrand L., Marcelli A., Dausset J. HLA system and side effects of gold salts and D-penicillamine treatment of rheumatoid arthritis. Ann Rheum Dis. 1982 Dec;41(6):599–601. doi: 10.1136/ard.41.6.599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hazelton R. A., Dick H. M., McKay S., Sturrock R. D. Immunogenetic insights into rheumatoid arthritis: a family study. Q J Med. 1982 Summer;51(203):336–340. [PubMed] [Google Scholar]
  4. Karsh J., Klippel J. H., Mann D. L., Reinertsen J. L., Moutsopoulos H. M., Johnson A. H., Decker J. L. Histocompatibility antigen combinations in rheumatoid arthritis. Clin Exp Rheumatol. 1983 Jan-Mar;1(1):11–15. [PubMed] [Google Scholar]
  5. Khan M. A., Kushner I., Weitkamp L. R. Genetics of HLA-associated disease; rheumatoid arthritis. Tissue Antigens. 1983 Sep;22(3):182–185. doi: 10.1111/j.1399-0039.1983.tb01189.x. [DOI] [PubMed] [Google Scholar]
  6. Legrand L., Lathrop G. M., Marcelli-Barge A., Dryll A., Bardin T., Debeyre N., Poirier J. C., Schmid M., Ryckewaert A., Dausset J. HLA-DR genotype risks in seropositive rheumatoid arthritis. Am J Hum Genet. 1984 May;36(3):690–699. [PMC free article] [PubMed] [Google Scholar]
  7. McMichael A. J., Sasazuki T., McDevitt H. O., Payne R. O. Increased frequency of HLA-Cw3 and HLA-Dw4 in rheumatoid arthritis. Arthritis Rheum. 1977 Jun;20(5):1037–1042. doi: 10.1002/art.1780200501. [DOI] [PubMed] [Google Scholar]
  8. Moutsopoulos H. M., Mann D. L., Johnson A. H., Chused T. M. Genetic differences between primary and secondary sicca syndrome. N Engl J Med. 1979 Oct 4;301(14):761–763. doi: 10.1056/NEJM197910043011405. [DOI] [PubMed] [Google Scholar]
  9. Nunez G., Moore S. E., Ball G. V., Hurd E. R., Stastny P. Study of HLA antigens in ten multiple-case rheumatoid arthritis families. J Rheumatol. 1984 Apr;11(2):129–135. [PubMed] [Google Scholar]
  10. Nyulassy S., Ravingerová G., Zvarová E., Buc M. Letter: HL-A antigens in rheumatoid arthritis. Lancet. 1974 Mar 16;1(7855):450–451. doi: 10.1016/s0140-6736(74)92399-x. [DOI] [PubMed] [Google Scholar]
  11. Panayi G. S., Wooley P. H. B lymphocyte alloantigens in the study of the genetic basis of rheumatoid arthritis. Ann Rheum Dis. 1977 Aug;36(4):365–368. doi: 10.1136/ard.36.4.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Pellegrino M. A., Ferrone S., Dierich M. P., Reisfeld R. A. Enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromide. Clin Immunol Immunopathol. 1975 Jan;3(3):324–333. doi: 10.1016/0090-1229(75)90019-7. [DOI] [PubMed] [Google Scholar]
  13. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  14. Raum D., Awdeh Z., Glass D., Kammer G., Khan M. A., Coblyn J. S., Weinblatt M., Holdsworth D., Strong L., Rossen R. D. Extended haplotypes of chromosome 6 in adult rheumatoid arthritis. Arthritis Rheum. 1984 May;27(5):516–521. doi: 10.1002/art.1780270506. [DOI] [PubMed] [Google Scholar]
  15. Thomsen M., Morling N., Snorrason E., Svejgaard A., Sørensen S. F. HLA--Dw4 and rheumatoid arthritis. Tissue Antigens. 1979 Jan;13(1):56–60. doi: 10.1111/j.1399-0039.1979.tb01137.x. [DOI] [PubMed] [Google Scholar]
  16. Wooley P. H., Griffin J., Panayi G. S., Batchelor J. R., Welsh K. I., Gibson T. J. HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis. N Engl J Med. 1980 Aug 7;303(6):300–302. doi: 10.1056/NEJM198008073030602. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES