Abstract
The effective osmotic pressure across the blood-joint barrier is a key factor controlling synovial fluid volume and joint effusions. The effect of plasma colloid osmotic pressure (COP) on trans-synovial flow was studied directly in rabbit knees expanded by intra-articular fluid infusion. The synovial microcirculation was perfused with blood of varying COP. Absorption of fluid from the joint cavity was a linear function of COP; but albumin COP was only 78% effective across the blood-joint interface. Hyperosmolar solutions of small solutes (e.g., glucose) generated transient osmotic flows across the blood-joint barrier, but far less effectively than albumin. The hydraulic permeability of synovium increased at pathological intra-articular pressures--a phenomenon of potential importance to effusion kinetics.
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Selected References
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- HANSEN A. T. A self-recording electronic osmometer for quick, direct measurement of colloid osmotic pressure in small samples. Acta Physiol Scand. 1961 Nov-Dec;53:197–213. doi: 10.1111/j.1748-1716.1961.tb02278.x. [DOI] [PubMed] [Google Scholar]
- Järhult J., Holmberg J., Lundvall J., Mellander S. Hyperglycemic and hyperosmolar responses to graded hemorrhage. Acta Physiol Scand. 1976 Aug;97(4):470–475. doi: 10.1111/j.1748-1716.1976.tb10286.x. [DOI] [PubMed] [Google Scholar]
- Knight A. D., Levick J. R. Effect of fluid pressure on the hydraulic conductance of interstitium and fenestrated endothelium in the rabbit knee. J Physiol. 1985 Mar;360:311–332. doi: 10.1113/jphysiol.1985.sp015619. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Knight A. D., Levick J. R. Pressure-volume relationships above and below atmospheric pressure in the synovial cavity of the rabbit knee. J Physiol. 1982 Jul;328:403–420. doi: 10.1113/jphysiol.1982.sp014273. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Knight A. D., Levick J. R. The influence of blood pressure on trans-synovial flow in the rabbit. J Physiol. 1984 Apr;349:27–42. doi: 10.1113/jphysiol.1984.sp015140. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levick J. R. Permeability of rheumatoid and normal human synovium to specific plasma proteins. Arthritis Rheum. 1981 Dec;24(12):1550–1560. doi: 10.1002/art.1780241215. [DOI] [PubMed] [Google Scholar]
- Levick J. R. The influence of hydrostatic pressure on trans-synovial fluid movement and on capsular expansion in the rabbit knee. J Physiol. 1979 Apr;289:69–82. doi: 10.1113/jphysiol.1979.sp012725. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Palmer D. G., Myers D. B. Some observations of joint effusions. Arthritis Rheum. 1968 Dec;11(6):745–755. doi: 10.1002/art.1780110604. [DOI] [PubMed] [Google Scholar]