Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1987 Aug;46(8):587–589. doi: 10.1136/ard.46.8.587

Immunoglobulin lambda light chain genes in rheumatoid arthritis.

D Sidebottom 1, D M Grennan 1, P A Sanders 1, A Read 1
PMCID: PMC1002204  PMID: 2889427

Abstract

Restriction fragment length polymorphisms (RFLPs) obtained by hybridisation of an immunoglobulin lambda constant region probe to Eco RI digests of genomic deoxyribonucleic acid (DNA) obtained from rheumatoid arthritis (RA) and control subjects have been compared. Polymorphic bands of 8, 13, 18, and 23 kb (kilobases) were shown. The 8/8 genotype and 8 kb allele were increased and the 8/18 genotype and 18 kb allele decreased in the RA group. This effect was independent of HLA and Gm. These findings suggest that genes linked to the loci for the immunoglobulin lambda constant region may influence susceptibility to RA.

Full text

PDF
587

Images in this article

588Image
on p.588

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson M. L., Szajnert M. F., Kaplan J. C., McColl L., Young B. D. The isolation of a human Ig V lambda gene from a recombinant library of chromosome 22 and estimation of its copy number. Nucleic Acids Res. 1984 Sep 11;12(17):6647–6661. doi: 10.1093/nar/12.17.6647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Feinberg A. P., Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem. 1983 Jul 1;132(1):6–13. doi: 10.1016/0003-2697(83)90418-9. [DOI] [PubMed] [Google Scholar]
  3. Hieter P. A., Hollis G. F., Korsmeyer S. J., Waldmann T. A., Leder P. Clustered arrangement of immunoglobulin lambda constant region genes in man. Nature. 1981 Dec 10;294(5841):536–540. doi: 10.1038/294536a0. [DOI] [PubMed] [Google Scholar]
  4. Kunkel L. M., Smith K. D., Boyer S. H., Borgaonkar D. S., Wachtel S. S., Miller O. J., Breg W. R., Jones H. W., Jr, Rary J. M. Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1245–1249. doi: 10.1073/pnas.74.3.1245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Nadalini V. F., Positano N., Bruttini G., Medica M. La nefrostomia percutanea utilizzando il principio di Desilets-Hoffman. Radiol Med. 1982;68(3):121–122. [PubMed] [Google Scholar]
  6. Sanders P. A., de Lange G. G., Dyer P. A., Grennan D. M. Gm and Km allotypes in rheumatoid arthritis. Ann Rheum Dis. 1985 Aug;44(8):529–532. doi: 10.1136/ard.44.8.529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Taub R. A., Hollis G. F., Hieter P. A., Korsmeyer S., Waldmann T. A., Leder P. Variable amplification of immunoglobulin lambda light-chain genes in human populations. Nature. 1983 Jul 14;304(5922):172–174. doi: 10.1038/304172a0. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES