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. 1987 Aug;46(8):612–616. doi: 10.1136/ard.46.8.612

Aortic occlusion in systemic lupus erythematosus associated with antiphospholipid antibodies.

P Drew 1, R A Asherson 1, R J Zuk 1, F J Goodwin 1, G R Hughes 1
PMCID: PMC1002209  PMID: 3116955

Abstract

The patient, a Caucasian woman of 22 years, developed malignant hypertension at the age of 16 years. An abdominal bruit was found on routine examination. She had two spontaneous abortions and systemic lupus erythematosus was diagnosed at age 21 years. She was found to have a persistently low positive VDRL and antibodies to mitochondria were also present on repeated examinations, to a titre of 1/160. Because of angiographic findings, demonstrating an occlusion of the aorta, an endarterectomy of the descending thoracic and upper abdominal aorta was performed. This showed mainly intimal thickening and the presence of thrombus. She then had four further spontaneous abortions (with good blood pressure control). The lupus anticoagulant and antibodies to cardiolipin were found to be positive at this time.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asherson R. A., Harris E. N. Anticardiolipin antibodies--clinical associations. Postgrad Med J. 1986 Dec;62(734):1081–1087. doi: 10.1136/pgmj.62.734.1081. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Asherson R. A., Harris E. N., Gharavi A. E., Englert H. E., Hughes G. R. Aortic arch syndrome associated with anticardiolipin antibodies and the lupus anticoagulant: comment on Ferrante paper. Arthritis Rheum. 1985 May;28(5):594–595. doi: 10.1002/art.1780280525. [DOI] [PubMed] [Google Scholar]
  3. Asherson R. A., Lanham J. G., Hull R. G., Boey M. L., Gharavi A. E., Hughes G. R. Renal vein thrombosis in systemic lupus erythematosus: association with the "lupus anticoagulant". Clin Exp Rheumatol. 1984 Jan-Mar;2(1):75–79. [PubMed] [Google Scholar]
  4. Asherson R. A., Mackworth-Young C. G., Harris E. N., Gharavi A. E., Hughes G. R. Multiple venous and arterial thromboses associated with the lupus anticoagulant and antibodies to cardiolipin in the absence of SLE. Rheumatol Int. 1985;5(2):91–93. doi: 10.1007/BF00270303. [DOI] [PubMed] [Google Scholar]
  5. Asherson R. A., Mercey D., Phillips G., Sheehan N., Gharavi A. E., Harris E. N., Hughes G. R. Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies. Ann Rheum Dis. 1987 Aug;46(8):605–611. doi: 10.1136/ard.46.8.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BOWIE E. J., THOMPSON J. H., Jr, PASCUZZI C. A., OWEN C. A., Jr THROMBOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS DESPITE CIRCULATING ANTICOAGULANTS. J Lab Clin Med. 1963 Sep;62:416–430. [PubMed] [Google Scholar]
  7. Harris E. N., Gharavi A. E., Asherson R. A., Boey M. L., Hughes G. R. Cerebral infarction in systemic lupus: association with anticardiolipin antibodies. Clin Exp Rheumatol. 1984 Jan-Mar;2(1):47–51. [PubMed] [Google Scholar]
  8. Harris E. N., Gharavi A. E., Boey M. L., Patel B. M., Mackworth-Young C. G., Loizou S., Hughes G. R. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet. 1983 Nov 26;2(8361):1211–1214. doi: 10.1016/s0140-6736(83)91267-9. [DOI] [PubMed] [Google Scholar]
  9. Hart R. G., Miller V. T., Coull B. M., Bril V. Cerebral infarction associated with lupus anticoagulants--preliminary report. Stroke. 1984 Jan-Feb;15(1):114–118. doi: 10.1161/01.str.15.1.114. [DOI] [PubMed] [Google Scholar]
  10. Hughes G. R., Harris N. N., Gharavi A. E. The anticardiolipin syndrome. J Rheumatol. 1986 Jun;13(3):486–489. [PubMed] [Google Scholar]
  11. JUDGE R. D., CURRIER R. D., GRACIE W. A., FIGLEY M. M. Takayasu's arteritis and the aortic arch syndrome. Am J Med. 1962 Mar;32:379–392. doi: 10.1016/0002-9343(62)90128-6. [DOI] [PubMed] [Google Scholar]
  12. LESSOF M. H., GLYNN L. E. The pulseless syndrome. Lancet. 1959 Apr 18;1(7077):799–801. doi: 10.1016/s0140-6736(59)91993-2. [DOI] [PubMed] [Google Scholar]
  13. Peck B., Hoffman G. S., Franck W. A. Thrombophlebitis in systemic lupus erythematosus. JAMA. 1978 Oct 13;240(16):1728–1730. [PubMed] [Google Scholar]
  14. SCHRIRE V., ASHERSON R. A. ARTERITIS OF THE AORTA AND ITS MAJOR BRANCHES. Q J Med. 1964 Oct;33:439–463. [PubMed] [Google Scholar]

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