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PLOS Global Public Health logoLink to PLOS Global Public Health
. 2022 May 31;2(5):e0000516. doi: 10.1371/journal.pgph.0000516

Depression, anxiety and stress among high school students: A cross-sectional study in an urban municipality of Kathmandu, Nepal

Anita Karki 1,*,#, Bipin Thapa 2,#, Pranil Man Singh Pradhan 3, Prem Basel 3,*
Editor: Khameer Kidia4
PMCID: PMC10022099  PMID: 36962418

Abstract

Depression and anxiety are the most widely recognized mental issues affecting youths. It is extremely important to investigate the burden and associated risk factors of these common mental disorders to combat them. Therefore, this study was undertaken with the aim to estimate the prevalence and identify factors associated with depression, anxiety, and stress among high school students in an urban municipality of Kathmandu, Nepal. A cross-sectional study was conducted among 453 students of five randomly selected high schools in Tokha Municipality of Kathmandu. Previously validated Nepali version of depression, anxiety, and stress scale (DASS-21) was used to assess the level of symptoms of depression, anxiety and stress (DAS). Multivariable logistic regression was carried out to decide statistically significant variables of symptoms of DAS at p-value<0.05. The overall prevalence of DAS was found to be 56.5% (95% CI: 51.8%, 61.1%), 55.6% (95%CI: 50.9%, 60.2%) and 32.9% (95%CI: 28.6%, 37.4%) respectively. In the multivariable model, nuclear family type, students from science or humanities faculty, presence of perceived academic stress, and being electronically bullied were found to be significantly associated with depression. Female sex, having mother with no formal education, students from science or humanities faculty and presence of perceived academic stress were significantly associated with anxiety. Likewise, female sex, currently living without parents, and presence of perceived academic stress were significantly associated with stress. Prevention and control activities such as school-based counseling services focusing to reduce and manage academic stress and electronic bullying are recommended in considering the findings of this research.

Introduction

Mental disorders contribute to a huge proportion of disease burden across all societies [1]. Among them, depression, anxiety and stress are the leading causes of illness and disability among adolescents [2]. The physical, psychological, and behavioral changes that occur throughout adolescence predispose them to a variety of mental health issues [3]. Despite this, mental health and mental disorders are largely ignored and not given the same importance as physical health [4].

The existing community-based studies conducted among high school students of various parts of Nepal have reported a wide range of prevalence of symptoms of depression and anxiety. The prevalence of depressive symptoms has been reported to range from 27% to 76% [57]. Likewise, the limited studies conducted in Nepal have estimated the proportion of symptoms of anxiety to range from 10% to 57% [79]. A nationwide survey conducted in Nepal revealed the prevalence of mental distress among adolescents (13-17years) to be 5.2% [10]. The Global School Health Survey which was a nationwide survey conducted in 2015 reported anxiety among 4.6% of the students [11].

Previous studies have revealed that sex [1216], staying away from home [17], grade [12, 14, 16], stream of study [18], academic performance and examination related issues [7, 19], cyber bullying [20] were linked with depression. Likewise, sex [8, 21], grade of students and type of school i.e., public or private [8], family type [17], not living with parents, educational level of parents [21] and high educational stress [22] had been the determinants of anxiety as per previous studies.

High school education is an important turning point in the life of academic students in Nepal [23]. As the educational system becomes more specialized and tough in high school, the students become more likely to experience stress at this level. This might put them at risk of developing common mental disorders such as depression, anxiety and stress (DAS). However, there is a paucity of research studies that have assessed DAS among high school students in Nepal.

Exploring the magnitude and risk factors of symptoms of DAS are very crucial to combat the burden of adolescent mental health issues [24]. However, due to limited access to psychological and psychiatric services as well as the significant social stigma associated with mental health issues, anxiety and depression in early adolescence frequently go undiagnosed and untreated, particularly in developing countries such as Nepal. Therefore, this study aimed to estimate the prevalence and identify factors associated with the symptoms of DAS among high school students in an urban municipality of Kathmandu, Nepal.

Materials and methods

Study setting, design, and population

This was a cross-sectional survey conducted in randomly selected high schools of Tokha Municipality, Kathmandu District in province no. 3 of Nepal. The data collection period was from 27th August to 11th September 2019. This municipality was formed on 7 December 2014 by merging five previous villages. It has an area of 16.2 sq.km. and comprises 11 wards [25, 26]. The municipality is rich in cultural and ethnic diversity [25]. According to Nepal government records as of 2017, there were total 218,554 students in Tokha municipality in 82 schools. High school students were the study population for this study [26]. In Nepal, high school students comprise of grade 11 and grade 12 students. The high school differs from lower schooling level since the students have the opportunity to enroll in specialized areas such as science, management, humanities and education. High school are also popularly known as 10+2 [27].

Sample size calculation and sampling technique

Sample size was estimated using the formula for cross-sectional survey [28], n = Z2p(1-p)/ e2 considering the following assumptions; proportion (p) = 0.24 [12], 95% confidence level, the margin of error of 5%. The estimated proportion used for sample size calculation was based on proportion of symptoms of anxiety i.e., 24%, as reported by a similar study conducted in Manipur, India [12].

After calculation, the minimum sample size required was 280. After adjusting for design effect of 1.5 to adjust variance from cluster design and assuming non-response rate of 10%, final sample of 467 was calculated. Two-stage cluster sampling was used. A list of all high schools of Tokha municipality was obtained from the education division of the municipality. Out of twelve high schools (8 private schools and 4 public schools), five schools were randomly selected. Within each selected high school further two sections each of grades 11 and 12 were randomly selected. A total of 20 sections were selected, 4 from each selected school, and all the students from the selected sections were included in the study.

Data collection tools

A structured questionnaire was prepared based on our study objectives which was divided into three sections. The first section included information about socio-demographic, familial and academic characteristics of the students. The second section included two item question to assess socializing among the students which was based on a previous study by Vankim and Nelson [29], two questions to assess bullying among the students based on 2019 Youth Risk Behavior Survey [30] and one item question to assess perceived academic stress. The third section consisted of Depression, Anxiety and Stress Scale (DASS-21) used to assess level of symptoms of depression, anxiety and stress among the students.

DASS-21 is a psychological screening instrument capable of differentiating symptoms of DAS. Depression, anxiety, and stress are three subscales and there are 7 items in each subscale. Each item is scored on a 4-point Likert scale which ranges from 0 i.e., did not apply to me at all to 3 i.e., applied to me very much. Scores for DAS were calculated by summing the scores for the relevant items. and multiplying by two [31]. A previously validated Nepali version of DASS-21 was obtained and used for data collection. Nepali version of the DASS-21 has demonstrated adequate internal consistency and validity. However, in the validation paper, the construct validity of the tool was evaluated against life satisfaction scale and not a systematic diagnostic tool [32]. Reliability for the symptoms of DAS was tested by Cronbach alpha. Cronbach alpha values for DAS were 0.74, 0.77, and 0.74 respectively.

Data collection procedure and technique

Data was collected after obtaining permission from the municipality’s education division as well as individual high schools. The questionnaire was in both English and Nepali language and had been pre-tested among 45 high school students of neighboring municipality. Self-administered anonymous questionnaires were distributed to students in their respective classrooms and requested for participation. An orientation session was conducted for the filling the questionnaire before distribution. Written informed consent was taken from all students prior to data collection whereas additional written parental consent was obtained from students below 18 years of age. One of the investigators herself collected the data from students. After data collection, a session on depression, anxiety, and stress along with the importance of discussing it with the guardians/ teachers and asking for help was conducted.

Study variables

The study variables are described in Table 1.

Table 1. Summary of study variables.

Variables Definitions of Variables Measurements
A. Dependent variables
Level of depression Level of symptoms of depression distinguished by DASS-21 scale Normal (0–9), mild (10–13), moderate depression (14–20), severe depression (21–27) and extremely severe depression (>27)
• No Depression (0–9)
• Depression (>9)
Level of anxiety Level of symptoms of anxiety distinguished by DASS-21 scale Normal (0–7), mild (8–9), moderate anxiety (10–14), severe anxiety (15–19) and extremely severe anxiety (>19)
• No anxiety (0–7)
• Anxiety (>7)
Level of stress Level of symptoms of stress distinguished by DASS-21 scale Normal (0–14), mild (15–18), moderate stress (19–25), severe stress (26–33) and extremely severe stress (>33)
• No stress (0–14)
• Stress (>14)
B. Independent variables
Socio-demographic characteristics
Age Age of the student in completed years at the time of the survey • Below 18
• 18 and above
Sex Sex of the participant • Male
• Female
• Others
Current living status The current living condition of the student at the time of survey • With parents (Staying with parents).
• Without parents (Staying with relative, staying in hostel, staying with friends, staying with husband/wife, others)
Type of family Type of family based on composition of family members • Nuclear
• Non-nuclear (Joint or Extended)
Father’s education The highest level of education attained by the student’s father • No formal education (illiterate, can only read and write in Nepali).
• Formal education (Primary, Secondary, Higher secondary, Bachelor’s and above)
Mother’s education The highest level of education attained by the student’s mother • No formal education (illiterate, can only read and write in Nepali).
• Formal education (Primary, Secondary, Higher Secondary, Bachelor’s and above)
Academic characteristics
Type of school The type of school where the student was studying at the time of survey • Public
• Private
Grade The current grade of the student at the time of the survey • Twelve
• Eleven
Stream/Faculty The stream or faculty in which student was enrolled at the time of survey • Humanities/Science
• Management
Failure in previous examination Academic record based on the result in the last examination attempted by the student • Failed
• Passed
Perceived academic stress Academic stress as rated by the student for themselves • Stressed
• Not Stressed
Contextual Characteristics
Socializing Socializing status of the students guided by a previous study by Vankim and Nelson • High
• Low
Bullied electronically Bullying status in the past 12 months via any electronic media as reported by the student • Yes
• No
Bullied on school property Bullying status in the past 12 months on school property reported by the student • Yes
• No

Data analysis

Compilation of data was done in EpiData 3.1 and then exported to IBM SPSS Statistics version 20 (IBM Corp., Armonk, NY) for cleaning and analysis. Descriptive analysis was performed. Frequency tables with percentages were generated for categorical variables, while mean and standard deviation (SD) were calculated for continuous variables.

Binary logistic regression was performed to identify associated factors of symptoms of DAS. Firstly, we performed univariate analysis in which each co-variate was modeled separately to determine the odds of DAS. Those variables with p-value <0.15 in univariate analysis were identified as candidate variables for multivariable logistic regression. In multivariable logistic regression, a p-value of < .05 was considered to be statistically significant and strength of association was measured using adjusted odds ratio (AOR) at 95% confidence interval.

Multicollinearity of variables was tested before entering them in the regression analysis. No problem of multicollinearity was seen among the variables (the highest observed VIF was 1.25,1.10 and 1.13 for symptoms of DAS respectively. The goodness of fit of the regression model was tested by the application of the Hosmer and Lemeshow test; the model was found to be a good fit (P >.05).

The regression model was explained by the equation:

Log [Y/ (1-Y)] = b0 + b1 X1 + b2 X2 + b3 X3… ..bnXn + e

Where Y is the expected probability for the outcome variable to occur, b0 is the constant/intercept, b1 through bn are the regression coefficients and the X1 through Xn are distinct independent variables and e is the error term.

Ethical approval and consent

The study protocol was approved by the Institutional Review Committee (IRC) of the Institute of Medicine, Tribhuvan University (Reference no. 23/ (6–11) 76/077). Approval to conduct this study was also obtained from the education division of Tokha Municipality (Ref: 076/077-23) and respective school authorities. A written informed consent (in the Nepali language) was obtained from the students before the data collection to assure their willingness to participate and no identifiers were listed in the questionnaire to make it anonymous and confidential. Parental consent was obtained for students who were under the age of 18. No incentives were provided.

Results

Sociodemographic, academic and contextual characteristics of the students

The research questionnaire was distributed to a sample of 468 high school students, one of whom refused to participate in this study, with a response rate of 99.78%. Responses from 14 students were excluded due to incompleteness. This study presents the analysis on a total of 453 students.

The mean age of the students was 16.99 years (SD = ±1.12), ranging from 14 to 22 years. The proportion of female students (54.1%) was higher than male students (45.9%). Majority of the students were found to be currently living with their parents i.e., 65.8%. Around 70% of the students were from nuclear family. Regarding parent’s educational level, majority of the students responded that their father as well as mother had attained secondary level of education i.e., 31.6% and 33.3% respectively.

With regards to academic characteristics, more than two- third of students i.e., 69.5% were from private high schools while the remaining 30.5% were studying in a government or public high school. More than half i.e. (53.4%) of the students studied in grade eleven. About half of the students i.e., 50.6% were from management faculty. Only 3.8% students reported to have failed in the previous examination.

It was noted that about 60% of students perceived themselves to be stressed due to their studies. Most students were low socializing i.e., 60.9%. Around one-tenth students reported being bullied electronically in the past 12 months (10.2%). Similar proportion of students i.e., 10.4% also reported being bullied on school property in the past 12 months (Table 2).

Table 2. Distribution of the students by socio-demographic, academic and contextual characteristics (n = 453).

Characteristics n %
Age  
Mean ± SD 16.99±1.12
Below 18 335 74.0
18 and above 118 26.0
Sex
Female 245 54.1
Male 208 45.9
Current living status
Staying with parents 298 65.8
Staying with relatives 96 21.2
Staying with friends 19 4.2
Staying in hostel 15 3.3
Staying with husband/wife 1 0.2
Staying with brother or sister 15 3.3
Staying alone 9 2.0
Type of family
Nuclear 319 70.4
Joint 117 25.8
Extended 17 3.8
Father’s education
Illiterate 39 8.6
Only read and write in Nepali 64 14.1
Primary 77 17.0
Secondary 143 31.6
Higher Secondary Level 88 19.4
Bachelor’s and above 42 9.3
Mother’s education
Illiterate 72 15.9
Only read and write in Nepali 90 19.9
Primary 67 14.8
Secondary 151 33.3
Higher Secondary Level 49 10.8
Bachelor’s and above 24 5.3
Type of School
Private 315 69.5
Public 138 30.5
Grade
Twelve 211 46.6
Eleven 242 53.4
Stream/Faculty
Science 128 28.3
Management 229 50.6
Humanities 57 12.6
Education 35 7.7
Special Law 4 0.9
Failure in previous exam
Yes 17 3.8
No 436 96.2
Perceived academic stress
Stressed 272 60.0
Neutral 93 20.5
Not stressed 88 19.4
Socializing
High-socializing 177 39.1
Low-socializing 276 60.9
Bullied electronically
Yes 46 10.2
No 407 89.8
Bullied on school property
Yes 47 10.4
No 406 89.6

Level of symptoms of DAS among the students

The prevalence of symptoms of DAS was found to be 56.5% (51.8%, 61.1%), 55.6% (50.9%, 60.2%) and 32.9% (28.6%, 37.4%) respectively. About a quarter of students showed moderate level of symptoms of depression and anxiety i.e., 25.8% and 24.5% respectively. On the other hand, symptoms of mild stress were most prevalent among the students. i.e., 14.8% (Table 3).

Table 3. Level of symptoms of DAS among the students (n = 453).

Level Depression Anxiety Stress
n % n % n %
None 197 43.5 201 44.4 304 67.1
Mild 84 18.5 39 8.6 67 14.8
Moderate 117 25.8 111 24.5 53 11.7
Severe 39 8.6 43 9.5 24 5.3
Extremely Severe 16 3.5 59 13.0 5 1.1
Overall 256 56.5 252 55.6 149 32.9

Factors associated with symptoms of depression

The results from multivariable logistic regression analyses for correlates of symptoms of depression are shown in Table 4. The variables that remain in the final model were age, type of family, father’s education, mother’s education, type of school, grade, faculty, perceived academic stress, and bullied electronically as these variables had p-value less than 0.15 in the univariate model. In the final model, nuclear family type (AOR: 1.64, 95% CI: 1.06–2.52), students from science/humanities faculty (AOR: 1.58, 95% CI: 1.05–2.40), presence of perceived academic stress (AOR: 1.62, 95% CI: 1.08–2.44) and bullied electronically in past 12 months (AOR: 2.84, 95% CI: 1.34–5.99) were significantly associated with symptoms of depression.

Table 4. Factors associated with symptoms of depression among the high school students of an urban municipality in Kathmandu (n = 453).

Characteristics Symptoms of depression COR (95% CI) AOR (95%CI)
Yes (%) No (%)
Age
≥18 years 81 (68.6) 37(31.4) 2.00 (1.28–3.12) 1.56(0.96–2.53)
<18 years 175 (52.2) 160 (47.8) 1 1
Type of family
Nuclear 190 (59.6) 129 (40.4) 1.52 (1.01–2.28) 1.64(1.06–2.52) *
Non-nuclear 66 (49.3) 68 (50.7) 1 1
Father’s education
No Formal Education 68 (66.0) 35 (34.0) 1.67 (1.06–2.65) 1.31(0.79–2.19)
Formal Education 188 (53.7) 162 (46.3) 1 1
Mother’s education
No formal education 106 (65.4) 56(34.6) 1.78(1.20–2.65) 1.46(0.93–2.30)
Formal Education 150 (51.5) 141 (48.5) 1 1
Type of school
Public 90 (65.2) 48 (34.8) 1.68(1.11–2.55) 1.16(0.73–1.84)
Private 166 (52.7) 149 (47.3) 1 1
Grade
Twelve 133 (63.0) 78 (37.0) 1.65 (1.13–2.40) 1.22(0.79–1.90)
Eleven 123 (50.8) 119 (49.2) 1 1
Stream/Faculty
Humanities/science 142(63.4) 82 (36.6) 1.75(1.20–2.54) 1.58(1.05–2.40) *
Management 114(49.8) 115 (50.2) 1 1
Perceived Academic Stress
Stressed 169 (62.1) 103 (37.9) 1.77(1.21–2 .59) 1.62(1.08–2.44) *
Not stressed 87 (48.1) 94 (51.9) 1 1
Bullied electronically
Yes 36 (78.3) 10 (21.7) 3.06 (1.48–6.33) 2.84(1.34–5.99) *
No 220 (54.1) 187 (45.9) 1 1

Hosmer and Lemeshow goodness-of-fit test p-value = 0.77

* p< .05

Factors associated with symptoms of anxiety

The results from multivariable logistic regression analyses for correlates of symptoms of anxiety are shown in Table 5. The variables that remained in the final model were age, sex, mother’s education, stream/ faculty, perceived academic stress, bullied electronically, and bullied on school property (p<0.15). Female sex (AOR: 1.82, 95% CI: 1.23–2.71), no formal education attained by the mother (AOR: 1.63, 95% CI: 1.08–2.47), students from science or humanities faculties (AOR: 1.50, 95% CI: 1.01–2.21), and presence of perceived academic stress (AOR: 1.93, 95% CI: 1.30–2.87), and were significantly associated with symptoms of anxiety.

Table 5. Factors associated with symptoms of anxiety among high school students of an urban municipality in Kathmandu (n = 453).

Characteristics Symptoms of anxiety COR (95% CI) AOR (95%CI)
Yes (%) No (%)
Age
≥18 years 73 (61.9) 45 (38.1) 1.41(.92–2.17) 1.29(0.81–2.04)
<18 years 179 (53.4) 156 (46.6) 1 1
Sex
Female 150 (61.2) 95 (38.8) 1.64 (1.13–2.39) 1.82(1.23–2.71) *
Male 102 (49.0) 106 (51.0) 1 1
Mother’s education
No formal education 103 (63.6) 59(36.4) 1.66(1.12–2.47) 1.63(1.08–2.47)*
Formal education 149 (51.2) 142 (48.8) 1 1
Stream/Faculty
Humanities/science 136(60.7) 88 (39.3) 1.51(1.04–2.19) 1.50(1.01–2.21) *
Management 116(50.7) 113 (49.3) 1 1
Perceived academic stress
Stressed 170 (62.5) 102 (37.5) 2.01(1.37–2.95 ) 1.93(1.30–2.87) *
Not stressed 82 (45.3) 99 (54.7) 1 1
Bullied electronically
Yes 32 (69.6) 14 (30.4) 1.94 (1.01–3.75) 1.60(0.80–3.22)
No 220 (54.1) 187 (45.9) 1 1
Bullied on school property
Yes 31(66.0) 16 (34.0) 1.62(0.86–3.06) 1.36(0.68–2.68)
No 221(54.4) 185 (45.6) 1 1

(Hosmer and Lemeshow goodness-of-fit test p-value = 0.42)

* p< .05

Factors associated with symptoms of stress

The results from multivariable logistic regression analyses for main correlates of symptoms of stress are shown in Table 6. The variables that remained in the final model were sex, current living status, grade, stream / faculty, perceived academic stress, bullied electronically and bullied on school property. In the final model, female sex (AOR: 1.54, 95% CI: 1.01–2.34), currently living without parents, (AOR: 1.70, 95% CI: 1.11–2.61), and presence of perceived academic stress (AOR: 2.11, 95% CI: 1.36–3.26) were significantly associated with stress symptoms.

Table 6. Factors associated with symptoms of stress among the high school students of an urban municipality in Kathmandu (n = 453).

Characteristics Symptoms of stress COR (95% CI) AOR (95%CI)
Yes (%) No (%)
Sex
Female 88 (35.9) 157 (64.1) 1.35(.91–2.01) 1.54(1.01–2.34) *
Male 61 (29.3) 147 (70.7) 1 1
Current living status
Without parents 62 (40.0) 93(60.0) 1.62(1.08–2.43) 1.70(1.11–2.61) *
With parents 87 (29.2) 211 (70.8) 1 1
Grade
Twelve 79 (37.4) 132 (62.6) 1.47 (.99–2.18 ) 1.23(0.80–1.89)
Eleven 70 (28.9) 172 (71.1) 1 1
Stream/Faculty
Humanities/science 81(36.2) 143(63.8) 1.34(0.91–1.99) 1.28(0.83–1.96)
Management 68(29.7) 161 (70.3) 1 1
Perceived academic stress
Stressed 108 (39.7) 164 (60.3) 2.25 (1.47–3.44) 2.11(1.36–3.26) *
Not stressed 41 (22.7) 140 (77.3) 1 1
Bullied electronically
Yes 22 (47.8) 24 (52.2) 2.02 (1.09–3.74) 1.60(0.83–3.08)
No 127 (31.2) 280 (68.8) 1 1
Bullied on school property
Yes 22(46.8) 25 (53.2) 1.93(1.05–3.55) 1.48(0.76–2.88)
No 127(31.3) 279 (68.7) 1 1

(Hosmer and Lemeshow p = 0.68)

* p< .05

Discussion

In our study, the prevalence of depressive symptoms among high school students was found to be 56.5%. The existing community-based studies conducted among high school students of various parts of Nepal have reported a wide range of prevalence of depressive symptoms. A study by Gautam et al. reported that more than one quarter i.e., 27% of high school students in a rural setting of Nepal showed depressive symptoms [6]. Similarly, in a study conducted by Bhattarai et. al. in four schools of a metropolitan city in Nepal, it was found that more than 2/5th i.e., 44.2% students exhibited depressive symptoms [5]. Similar proportion of depressive symptoms i.e., 41.6% was also reported by Sharma et. al in a study conducted among adolescent students of public schools of Kathmandu [9]. The prevalence estimated by these studies are lower than the findings of our study [5, 6, 9]. On contrary, a single high school study by Bhandari et al reported depressive symptoms among 76% students [7]. In our study, the proportion of students showing symptoms of anxiety were 55.6%. A study by Sharma et al. revealed that more than half i.e. 56.9% of public high school students showed symptoms of anxiety [9]. Another study by Bhandari et. al, also found out that nearly one out of two students i.e., 46.5% suffered from anxiety [8].These findings are in line with the findings of our study. On contrary, a study by Bhandari reported that only 10% students had mild anxiety [7]. In our study, the prevalence of stress symptoms among students was 32.9%. A study by Sharma et. al reported that more than 1/4th students i.e., 27.5% showed symptoms of stress which corroborates with the findings of our study.

While the prevalence of symptoms of DAS reported by our study corroborates with the existing literatures in Nepal, it is exceptionally high. One possible explanation for this could be that the data was collected at the beginning of academic session. The students in the eleventh grade were undergoing sudden transition from secondary school life to high school life with regards to new friends, teachers, school environment, and change in daily schedules whereas the students in 12th grade were awaiting results of previous board exam. This anticipation and the tremendous pressure faced by 12th grade students for tertiary education might have contributed to the high prevalence of symptoms of DAS among 12th grade students whereas the higher prevalence of symptoms of DAS among 11th grade students could be possibly explained by the inability to cope with the adjustment of sudden transition from secondary to high school life. Moreover, the wide range in prevalence of DAS symptoms among these community-based studies could be attributed to the difference in the setting (rural or urban) and difference in methodology used.

Among South Asian countries, the prevalence of depression reported by our study is in line with the studies conducted in India, and Bangladesh, but slightly higher than one conducted in China and [13, 17, 33, 34]. On contrary, our study has shown higher prevalence of anxiety among students as compared to study conducted in India, Sri Lanka, Vietnam and China [12, 19, 22, 34].The prevalence of symptoms of stress in this study is comparable to the study from Chandigarh but higher than similar study from Manipur, India [12, 17]. Hence, it can be suggested that there is a huge burden of DAS among high school students in South Asia. In context of Nepal, there is no standalone mental health policy. Further, there is inadequate funding allocated for mental health services along with shortage of qualified mental health professionals. In addition, there is much stigma that surrounds mental illness which acts as a barrier to seek and utilize mental health care services [35]. Due to these reasons, mental health illnesses are likely to remain untreated and continue to persist in the society. This may explain the high prevalence of DAS in our setting.

Socio-demographic characteristics and association with symptoms of DAS (depression, anxiety and stress)

In current study, it was found that females were more likely to suffer from symptoms of anxiety and stress than their male counterparts. This finding corroborates with the findings from previous studies [19, 21, 3639]. On the contrary, a study conducted in Dang, Nepal reported that males were 1.5 times more likely to become anxious [8].One possible explanation for this is adolescent stage in girls is marked by hormonal changes as a result of various reproductive events which may have a role in the etiology of anxiety disorders [40]. Furthermore, when compared to boys, girls are more likely to be subjected to stressful situations such as sexual and domestic violence, which may make them more prone to anxiety and stress problems [41].

This study revealed that the students who live in nuclear families were more likely to exhibit depressive symptoms compared to students from joint or extended families. There are more members in a joint family system, which may provide better opportunities for adolescents to share their emotions and issues, hence providing a strong support system that may serve as a protective factor against depression which may be lacking in nuclear families [42]. Moreover, this study also found out that risks of stress symptoms was higher among students who were staying far from their parents. A similar finding was reported by Arif et al., 2019 in Uttar Pradesh, India [43]. One of the possible explanations might be that students who live without their parents may spend a substantial amount of time alone after school, which does not encourage familial intimacy [44]. As a result, they may feel alone and disconnected from their parents [45]. These adolescents may miss out on the opportunity to internalize the support they would otherwise get, leading to increased stress.

In our study, the students who reported no formal mother’s education were at greater risk of showing symptoms of anxiety. This was in accordance with other similar studies [38, 46]. The attachment theory provides a robust foundation for understanding how parental behavior affects a child’s ability to recognize and manage stressful events throughout their lives [47]. The theory supports that the educated mother plays a stronger parenting role in the development of emotional skills and mental health outcomes in teenagers which might be protective for anxiety.

Academic characteristics and association with symptoms of DAS

In our study, the students from science or humanities faculties were more likely to have depression and anxiety as compared to management students. This was in line with other studies which showed higher proportion of depressive symptoms among science students. [48]. Generally, science students have to compete more, study longer hours and have a higher level of curriculum difficulty than management students which explains the finding. Likewise, it is believed that the humanities students have a poorer past academic performance in the secondary school, and may have chosen this stream / faculty as a secondary choice [49]. This combined with the uncertainty regarding future work prospects among humanities students may likely explain the higher prevalence of depression among humanities students.

In our study, the students who reported to be stressed due to their studies were more likely to suffer from symptoms of DAS. Several studies have documented similar findings [7, 22]. A possible explanation might be that high school is an important stage in an individual’s academic life. However, the inability to meet the expectation of parents, teachers, and oneself in terms of academic performance can lead to overburden of stress [50]. This persistent academic related stress might accelerate the development of mood disorders such as depression, anxiety and stress among the adolescents [51].

Contextual factors and association with symptoms of DAS

In our study, the risk of depressive symptoms was higher among those students who were bullied via electronic means. Literature suggests that higher the level of cyberbullying/electronic bullying leads to higher the level of depressive symptoms among adolescents [52]. A similar study by Perren et. al demonstrated that depression was significantly associated with cyberbullying even after controlling for traditional forms of bullying [20]. The victims of cyberbullying may experience anonymous verbal or visual threats via electronic means. These repeated incidents can cause the victims to feel powerless which exacerbates the feeling of fear. This can cause significant emotional distress among victims and contribute to development of depressive symptoms [53].

Even though widely utilized in both clinical as well as research setting, DASS scales are screening tools for symptoms of depression, anxiety, and stress. Hence, they cannot be used as a modality for diagnosis. This limitation should be considered when interpreting the findings of this study. Due to its cross-sectional design, this study was unable to establish causal relationship of depression, anxiety, and stress with associated factors. Since the study tools used in this study investigate the habits and activities of the high school students in the past, recall and reporting bias are likely; however, the effect due to potential confounders have been controlled. As Nepal is a culturally diverse country, the findings of only one municipality may not be generalized to the whole country. Therefore, future studies covering a larger population of high school students employing more robust study designs such as interventional studies are recommended to get the real scenario of common mental disorders.

Conclusion

In conclusion, more than half of the students had depression and anxiety symptoms and nearly one third of the students had stress symptoms. Nuclear family type, students from humanities/science faculty, presence of perceived academic stress, and being bullied electronically were found to be significantly associated with symptoms of depression. Female sex, no formal mother education, students from humanities/science faculty, and presence of perceived academic stress were significantly associated with symptoms of anxiety. Likewise, symptoms of stress were significantly associated with female sex, currently living without parents, and presence of perceived academic stress.

Therefore, prevention and control activities such as school-based counseling services focusing to reduce and manage academic stress and electronic bullying faced by the students are recommended considering findings of this research.

Supporting information

S1 File. Questionnaire form used in data collection.

(PDF)

Acknowledgments

We are grateful to Tokha municipality for granting permission to conduct the study. Special thank goes to the school management and teachers for their co-ordination during data collection. Lastly, we would like to thank all the study participants for their co-operation and support during the study.

Data Availability

The data that support the findings of descriptive analysis of this study are available in Figshare with the identifier given below: https://doi.org/10.6084/m9.figshare.19203512 The data that support the findings of inferential analysis of this study are available in Figshare with the identifier given below: https://doi.org/10.6084/m9.figshare.19203491.

Funding Statement

The authors received no specific funding for this work.

References

  • 1.Patel V, Flisher AJ, Hetrick S, McGorry P. Mental health of young people: a global public-health challenge. Lancet. 2007;369: 1302–1313. doi: 10.1016/S0140-6736(07)60368-7 [DOI] [PubMed] [Google Scholar]
  • 2.Adolescent mental health. [cited 27 Jul 2021]. Available: https://www.who.int/news-room/fact-sheets/detail/adolescent-mental-health
  • 3.World Health Organization. Regional Office for South-East Asia. Mental health status of adolescents in South-East Asia: evidence for action. New Delhi: World Health Organization. Regional Office for South-East Asia; 2017. Available: https://apps.who.int/iris/handle/10665/254982%0A [Google Scholar]
  • 4.World Health Organization (WHO). Investing in mental health. Investing in mental health. 2003. Available: https://apps.who.int/iris/handle/10665/42823 [Google Scholar]
  • 5.Bhattarai D, Shrestha N, Paudel S. Prevalence and factors associated with depression among higher secondary school adolescents of Pokhara Metropolitan, Nepal: a cross-sectional study. BMJ Open. 2020;10: e044042. doi: 10.1136/bmjopen-2020-044042 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Gautam P, Dahal M, Ghimire H, Chapagain S, Baral K, Acharya R, et al. Depression among Adolescents of Rural Nepal: A Community-Based Study. Depress Res Treat. 2021;2021. doi: 10.1155/2021/7495141 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Bhandari M. Anxiety and depression among adolescent students at higher secondary school. BIBECHANA. 2016;14: 113–129. 10.3126/bibechana.v14i0.16019 [DOI] [Google Scholar]
  • 8.Bhandari K, Adhikari C. Prevalence and Factors Associated with Anxiety Disorder among Secondary School Adolescents of Dang District, Nepal. In: Journal of Gandaki Medical College—Nepal [Internet]. 2015. [cited 2 Jan 2022] pp. 53–56. Available: www.gmc.edu.np [Google Scholar]
  • 9.Sharma P, Choulagai B. Stress, anxiety, and depression among adolescent students of public schools in Kathmandu. [cited 19 Mar 2022]. Available: www.jiom.com.np
  • 10.Nepal Health Research Council. National Mental Health Survey, Nepal-2020. In: Nepal Health Research Council; [Internet]. 2020. pp. 1–4. Available: http://nhrc.gov.np/projects/nepal-mental-health-survey-2017-2018/ [Google Scholar]
  • 11.Kumar Aryal K, Bista B, Bahadur Khadka B, Raj Pandey A, Mehta R, Kumar Jha B, et al. Global School Based Student Health Survey Nepal-2015. Nepal Health Research Council; 2017. Available: http://nhrc.gov.np/wp-content/uploads/2017/10/Ghsh-final-with-cover-and-anex.pdf [Google Scholar]
  • 12.Kumar KS, Akoijam BS. Depression, Anxiety and Stress Among Higher Secondary School Students of Imphal, Manipur. Indian J Community Med. 2017;42: 94. doi: 10.4103/ijcm.IJCM_266_15 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.Jha KK, Singh SK, Nirala SK, Kumar C, Kumar P, Aggrawal N. Prevalence of Depression among School-going Adolescents in an Urban Area of Bihar, India. Indian J Psychol Med. 2017;39: 287–292. doi: 10.4103/0253-7176.207326 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Bhasin SK, Sharma R, Saini NK. Depression, anxiety and stress among adolescent students belonging to affluent families: a school-based study. Indian J Pediatr. 2010;77: 161–165. doi: 10.1007/s12098-009-0260-5 [DOI] [PubMed] [Google Scholar]
  • 15.Buabbas AJ, Hasan H, Buabbas MA. The associations between smart device use and psychological distress among secondary and high school students in Kuwait. PLoS One. 2021;16: e0251479. doi: 10.1371/journal.pone.0251479 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Anjum A, Hossain S, Sikder T, Uddin ME, Rahim DA. Investigating the prevalence of and factors associated with depressive symptoms among urban and semi-urban school adolescents in Bangladesh: a pilot study. Int Health. 2019;00: 1–9. doi: 10.1093/inthealth/ihz092 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Sandal RK, Goel NK, Sharma MK, Bakshi RK, Singh N, Kumar D. Prevalence of Depression, Anxiety and Stress among school going adolescent in Chandigarh. J Fam Med Prim Care. 2017;6: 405. doi: 10.4103/2249-4863.219988 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Ang AL, Wahab S, Rahman FNA, Hazmi H, Yusoff RM. Depressive symptoms in adolescents in Kuching, Malaysia: Prevalence and associated factors. Pediatr Int. 2019;61: 404–410. doi: 10.1111/ped.13778 [DOI] [PubMed] [Google Scholar]
  • 19.Rodrigo C, Welgama S, Gurusinghe J, Wijeratne T, Jayananda G, Rajapakse S. Symptoms of anxiety and depression in adolescent students; a perspective from Sri Lanka. Child Adolesc Psychiatry Ment Heal 2010 41. 2010;4: 1–3. doi: 10.1186/1753-2000-4-10 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20.Perren S, Dooley J, Shaw T, Cross D. Bullying in school and cyberspace: Associations with depressive symptoms in Swiss and Australian adolescents. Child Adolesc Psychiatry Ment Health. 2010;4: 28. doi: 10.1186/1753-2000-4-28 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Abbo C, Kinyanda E, Kizza RB, Levin J, Ndyanabangi S, Stein DJ. Prevalence, comorbidity and predictors of anxiety disorders in children and adolescents in rural north-eastern Uganda. Child Adolesc Psychiatry Ment Health. 2013;7: 21. doi: 10.1186/1753-2000-7-21 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 22.Nguyen DT, Dedding C, Pham TT, Wright P, Bunders J. Depression, anxiety, and suicidal ideation among Vietnamese secondary school students and proposed solutions: a cross-sectional study. BMC Public Health. 2013;13: 1195. doi: 10.1186/1471-2458-13-1195 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Gurung M, Chansatitporn N, Chamroonsawasdi K, Lapvongwatana P. Academic Stress among High School Students in a Rural Area of Nepal: A Descriptive Cross-sectional Study. JNMA J Nepal Med Assoc. 2020;58: 306. doi: 10.31729/jnma.4978 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24.Fergusson DM, Woodward LJ. Mental Health, Educational, and Social Role Outcomes of Adolescents With Depression. Arch Gen Psychiatry. 2002;59: 225–231. doi: 10.1001/archpsyc.59.3.225 [DOI] [PubMed] [Google Scholar]
  • 25.Brief Introduction | Tokha Municipality, Office Of the Municipal Executive. [cited 25 Jul 2021]. Available: https://www.tokhamun.gov.np/en/node/4
  • 26.Tokha Municipality Profile | Facts & Statistics–Nepal Archives. [cited 25 Jul 2021]. Available: https://www.nepalarchives.com/content/tokha-municipality-kathmandu-profile/
  • 27.Nepal—Secondary Education—Level, Schools, Technical, and Training—StateUniversity.com. [cited 22 Mar 2022]. Available: https://education.stateuniversity.com/pages/1058/Nepal-SECONDARY-EDUCATION.html
  • 28.Charan J, Biswas T. How to Calculate Sample Size for Different Study Designs in Medical Research? Indian J Psychol Med. 2013;35: 121. doi: 10.4103/0253-7176.116232 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 29.Vankim NA, Nelson TF. Vigorous physical activity, mental health, perceived stress, and socializing among college students. Am J Health Promot. 2013;28: 7–15. doi: 10.4278/ajhp.111101-QUAN-395 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 30.2019 State and Local Youth Risk Behavior Survey. 2019; 7. Available: https://www.cdc.gov/healthyyouth/data/yrbs/pdf/2019/2019_YRBS-Standard-HS-Questionnaire.pdf
  • 31.Coker AO, Coker OO, Sanni D. Psychometric properties of the 21-item Depression Anxiety Stress Scale (DASS-21). African Res Rev. 2018;12: 135. doi: 10.4314/afrrev.v12i2.13 [DOI] [Google Scholar]
  • 32.Tonsing KN. Psychometric properties and validation of Nepali version of the Depression Anxiety Stress Scales (DASS-21). Asian J Psychiatr. 2014;8: 63–66. doi: 10.1016/j.ajp.2013.11.001 [DOI] [PubMed] [Google Scholar]
  • 33.Billah SMB, Khan FI. Depression among Urban Adolescent Students of Some Selected Schools. Faridpur Med Coll J. 2015;9: 73–75. doi: 10.3329/FMCJ.V9I2.25678 [DOI] [Google Scholar]
  • 34.Zhang SC, Yang R, Li DL, Wan YH, Tao FB, Fang J. Association of health literacy and sleep problems with mental health of Chinese students in combined junior and senior high school. PLoS One. 2019;14: e0217685. doi: 10.1371/journal.pone.0217685 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35.World Health Organization (WHO). Nepal WHO Special Initiative for Mental Health Situational Assessment CONTEXT.
  • 36.Alharbi R, Alsuhaibani K, Almarshad A, Alyahya A. Depression and anxiety among high school student at Qassim Region. J Fam Med Prim care. 2019;8: 504–510. doi: 10.4103/jfmpc.jfmpc_383_18 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 37.Mishra SK, Mona S, K TN. Prevalence of depression and anxiety among children in rural and suburban areas of Eastern Uttar Pradesh: A cross‑sectional study Shailendra. J Fam Med Prim Care. 2018;7: 21–26. doi: 10.4103/jfmpc.jfmpc [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 38.Mohammadi MR, Pourdehghan P, Mostafavi S-A, Hooshyari Z, Ahmadi N, Khaleghi A. Generalized anxiety disorder: Prevalence, predictors, and comorbidity in children and adolescents. J Anxiety Disord. 2020;73: 102234. doi: 10.1016/j.janxdis.2020.102234 [DOI] [PubMed] [Google Scholar]
  • 39.Simegn WI, Dagnew BI, Yeshaw YI, Yitayih S, Woldegerima B, Dagne HI. Depression, anxiety, stress and their associated factors among Ethiopian University students during an early stage of COVID-19 pandemic: An online-based cross-sectional survey. 2021. doi: 10.1371/journal.pone.0251670 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 40.Reardon LE, Leen-Feldner EW, Hayward C. A critical review of the empirical literature on the relation between anxiety and puberty. Clin Psychol Rev. 2009;29: 1–23. doi: 10.1016/j.cpr.2008.09.005 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 41.Christiansen DM. Examining Sex and Gender Differences in Anxiety Disorders. A Fresh Look Anxiety Disord. 2015. [cited 9 Oct 2021]. doi: 10.5772/60662 [DOI] [Google Scholar]
  • 42.Sahar N, Muzaffar NM. Role of Family System, Positive Emotions and Resilience in Social Adjustment among Pakistani Adolescents. J Educ Heal Community Psychol. 2017;6: 46. doi: 10.12928/jehcp.v6i2.6944 [DOI] [Google Scholar]
  • 43.Arif N, Yadav S, Gupta S. An epidemiological study of stress among adolescent of urban and rural Moradabad. Int J Med Sci Public Heal. 2019;8: 1. doi: 10.5455/ijmsph.2019.0512915062019 [DOI] [Google Scholar]
  • 44.Luthar SS. The culture of affluence: psychological costs of material wealth. Child Dev. 2003;74: 1581–1593. doi: 10.1046/j.1467-8624.2003.00625.x [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 45.Luthar SS, D’Avanzo K. Contextual factors in substance use: a study of suburban and inner-city adolescents. Dev Psychopathol. 1999;11: 845–867. doi: 10.1017/s0954579499002357 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 46.Yusoff MSB, Abdul Rahim AF, Baba AA, Ismail SB, Mat Pa MN, Esa AR. Prevalence and associated factors of stress, anxiety and depression among prospective medical students. Asian J Psychiatr. 2013;6: 128–133. doi: 10.1016/j.ajp.2012.09.012 [DOI] [PubMed] [Google Scholar]
  • 47.Mikulincer M, Shaver PR, Pereg D. Attachment Theory and Affect Regulation: The Dynamics, Development, and Cognitive Consequences of Attachment-Related Strategies. Motiv Emot. 2003;27: 77–102. doi: 10.1023/A:1024515519160 [DOI] [Google Scholar]
  • 48.Chokshi AS, Rangwala PP, Dumra GH, Thakrar MR, Singh AJ, Lakdawala BM. Depression, anxiety and stress amongst students in science verses non-science stream: a comparative study. Int J Community Med Public Heal. 2021;8: 3461. doi: 10.18203/2394-6040.IJCMPH20212602 [DOI] [Google Scholar]
  • 49.Baviskar M, Edward K, Hospital M, Instit P. Depression, Anxiety and stress : A comparative study in Arts, Science and Commerce students from a Rural area of India. 2013; 1–4. [Google Scholar]
  • 50.Waghachavare VB, Chavan VM, Dhumale GB, Gore a D. A Cross-Sectional Study of Stress Among Junior College Students in a Rural Area of Sangli District of Maharashtra. Innov J Med Heal Sci. 2013;3: 294–297. [Google Scholar]
  • 51.Pascoe MC, Hetrick SE, Parker AG. The impact of stress on students in secondary school and higher education. Int J Adolesc Youth. 2019; 1–9. doi: 10.1080/02673843.2019.159682332257623 [DOI] [Google Scholar]
  • 52.Nixon CL. Current perspectives: the impact of cyberbullying on adolescent health. Adolesc Health Med Ther. 2014;5: 143. doi: 10.2147/AHMT.S36456 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 53.Bottino SMB, Bottino CMC, Regina CG, Correia AVL, Ribeiro WS. Cyberbullying and adolescent mental health: systematic review. Cad Saude Publica. 2015;31: 463–475. doi: 10.1590/0102-311x00036114 [DOI] [PubMed] [Google Scholar]
PLOS Glob Public Health. doi: 10.1371/journal.pgph.0000516.r001

Decision Letter 0

Khameer Kidia

15 Mar 2022

PGPH-D-22-00294

Depression, anxiety and stress among high school students: A cross-sectional study in an urban municipality of Kathmandu, Nepal

PLOS Global Public Health

Dear Dr. Karki,

Thank you for submitting your manuscript to PLOS Global Public Health. After careful consideration, we feel that it has merit but does not fully meet PLOS Global Public Health’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

I am less concerned with Reviewer 1's comment 4 about the difference between the humanities and sciences. You do not need to overhaul the paper with respect to this comment, though some response is warranted. 

Please submit your revised manuscript by Apr 14 2022 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at globalpubhealth@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pgph/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

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We look forward to receiving your revised manuscript.

Kind regards,

Khameer Kidia

Academic Editor

PLOS Global Public Health

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1. Does this manuscript meet PLOS Global Public Health’s publication criteria? Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe methodologically and ethically rigorous research with conclusions that are appropriately drawn based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: This study looking at the prevalence and risk factors for common mental distress among adolescents has its significance as it tries to address a field that has limited studies in this geographical area. I think this manuscript and study could be strengthened.

There are some major concerns that I would like to share with the authors for improvements:

1. The author has written an introduction clearly providing the aim of the study. However, I would like to suggest the author look into recent studies highlighting the current prevalence of proposed outcome variables as many studies have been published since 2015-16. Furthermore, the overall prevalence of mental disorders among Nepalese adolescents provided by the National Mental Health Survey, Nepal-2020 has been reported in the discussion session, but I think it would be better to have it as an introduction as it covers a broader perspective.

2. In methodology, a study from India has been used as a reference for sample size estimation. I wonder why the author didn’t look for any Nepalese past prevalence. Moreover, the reference study has provided the proportion for depression, anxiety, and stress while only the proportion of anxiety has been used by the author for sample estimation. Was the proportion of anxiety selected purposively to obtain optimal sample size or was there any other reason to ignore the provided prevalence of depression and stress? I suggest the author can aim to make the sample estimation section more explanatory and clear.

3. Is there any specific reason that the authors set the level of significance at 15% for bivariate analysis while the AOR has been interpreted at a 5% level of significance?

4. Humanities and science are very diverse disciplines. Is there any specific reason that the author has grouped science and humanities while management as its counterpart? Moreover, other disciplines are mentioned in Table 2 which are merged during cross-tabulation without clear explanation. Furthermore, in the discussion author has tried to emphasize the complexity of science as a discipline but this interpretation seems misleading as humanities have also been accommodated in the same group in the current manuscript.

5. In the discussion section, it is nice that the author has mentioned the national prevalence of mental disorders among adolescents based on the National Mental Health Survey 2019-2020. However, the study has been referenced as a study from 2018 but the factsheet of this national survey was published in 2020 so the author might need to revise the reference accordingly.

6. I recommended that the author revisit their references focusing on studies based on adolescents and/or high school students. Medical/health science students might have more diverse characteristics than high school students. The author could shape the discussion by revisiting recent studies which have focused on depression among higher secondary school adolescents in Nepal and the Asian region.

7. In reference, some of the references are not attainable/assessable for instance current reference 29. Cross verification of the reference is required

Reviewer #2: This manuscript presents results from a cross-sectional survey of HS students in Kathmandu. Given the dearth of local epidemiological data, especially among young populations, this is an important study.

1. Given the variation in how “high school” is defined across the world, it will be helpful to describe it. It appears that 11th and 12th grades are included.

2. Please include that the validation paper [Ref 31] conducted construct validity against a life satisfaction scale. As such, the scale wasn’t validated against a systematic diagnostic instrument (e.g., a gold standard like SCID).

3. Perhaps relatedly, the overall prevalence is very high. Globally, community samples show 5% prevalence of depression but this study found >50% rate. While such rate may be possible, it is unusually high. Indeed, many community-based studies find a very wide range of prevalence. Additional context will be helpful to interpret these high rates. How close were upcoming examinations? Any other stressors that may have increased overall mood and anxiety? How common is it for HS students to be asked about these issues when they are in the classroom?

4. Overall, the language needs to be edited from “depression” and “anxiety” to “symptoms of depression” or “depressive symptoms” to clarify that the survey instrument is not diagnostic and is picking up presence of symptoms.

**********

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Reviewer #1: No

Reviewer #2: No

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PLOS Glob Public Health. doi: 10.1371/journal.pgph.0000516.r003

Decision Letter 1

Khameer Kidia

4 May 2022

Depression, anxiety and stress among high school students: A cross-sectional study in an urban municipality of Kathmandu, Nepal

PGPH-D-22-00294R1

Dear Ms. Karki,

We are pleased to inform you that your manuscript 'Depression, anxiety and stress among high school students: A cross-sectional study in an urban municipality of Kathmandu, Nepal' has been provisionally accepted for publication in PLOS Global Public Health.

Before your manuscript can be formally accepted you will need to complete some formatting changes, which you will receive in a follow up email. A member of our team will be in touch with a set of requests.

Please note that your manuscript will not be scheduled for publication until you have made the required changes, so a swift response is appreciated.

IMPORTANT: The editorial review process is now complete. PLOS will only permit corrections to spelling, formatting or significant scientific errors from this point onwards. Requests for major changes, or any which affect the scientific understanding of your work, will cause delays to the publication date of your manuscript.

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Thank you again for supporting Open Access publishing; we are looking forward to publishing your work in PLOS Global Public Health.

Best regards,

Khameer Kidia

Academic Editor

PLOS Global Public Health

***********************************************************

Reviewer Comments (if any, and for reference):

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    S1 File. Questionnaire form used in data collection.

    (PDF)

    Attachment

    Submitted filename: response to reviewers .docx

    Data Availability Statement

    The data that support the findings of descriptive analysis of this study are available in Figshare with the identifier given below: https://doi.org/10.6084/m9.figshare.19203512 The data that support the findings of inferential analysis of this study are available in Figshare with the identifier given below: https://doi.org/10.6084/m9.figshare.19203491.


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