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. 1987 Sep;46(9):658–663. doi: 10.1136/ard.46.9.658

Renal findings in rheumatoid arthritis: clinical aspects of 132 necropsies.

M Boers 1, A M Croonen 1, B A Dijkmans 1, F C Breedveld 1, F Eulderink 1, A Cats 1, J J Weening 1
PMCID: PMC1002227  PMID: 3675007

Abstract

Renal abnormalities in 132 necropsied patients with rheumatoid arthritis were studied. Clinical findings before death included extra-articular manifestations of the disease (86% of patients), systemic vasculitis (6%), and uraemia (23%). Necropsy findings included nephrosclerosis (90%), systemic vasculitis (14%) with kidney involvement in 8%, amyloidosis (11%), membranous glomerulopathy (8%), and focal glomerular disease (8%). Association with clinical data suggests that both rheumatoid and non-rheumatoid disease may play a part in the cause of these abnormalities.

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Selected References

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  1. ALLANDER E., BUCHT H., LOEVGREN O., WEHLE B. RENAL FUNCTION IN RHEUMATOID ARTHRITIS. Acta Rheumatol Scand. 1963;9:116–121. [PubMed] [Google Scholar]
  2. Bacon P. A., Tribe C. R., Mackenzie J. C., Verrier-Jones J., Cumming R. H., Amer B. Penicillamine nephropathy in rheumatoid arthritis. A clinical, pathological and immunological study. Q J Med. 1976 Oct;45(180):661–684. [PubMed] [Google Scholar]
  3. Brun C., Olsen T. S., Raaschou F., Sorensen A. W. Renal biopsy in rheumatoid arthritis. Nephron. 1965;2(2):65–81. doi: 10.1159/000179377. [DOI] [PubMed] [Google Scholar]
  4. Burry H. C. Reduced glomerular function in rheumatoid arthritis. Ann Rheum Dis. 1972 Jan;31(1):65–68. doi: 10.1136/ard.31.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Camp A. V., Mowat A. G., Fletcher W. B., Dunnill M. S., McIver A. G. A study of renal disease in rheumatoid arthritis. Ann Rheum Dis. 1973 May;32(3):278–279. doi: 10.1136/ard.32.3.278. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Davis J. A., Cohen A. H., Weisbart R., Paulus H. E. Glomerulonephritis in rheumatoid arthritis. Arthritis Rheum. 1979 Sep;22(9):1018–1023. doi: 10.1002/art.1780220911. [DOI] [PubMed] [Google Scholar]
  7. Delaire M., Kahn M. F., Morel-Maroger L., Méry J. P., de Sèze S. Le rein dans la polyarthrite rhumatoïde de l'adulte: étude anatomique. Rev Rhum Mal Osteoartic. 1974 Feb;41(2):105–111. [PubMed] [Google Scholar]
  8. Fingerman D. L., Andrus F. C. Visceral Lesions Associated with Rheumatoid Arthritis. Ann Rheum Dis. 1943 May;3(3):168–181. doi: 10.1136/ard.3.3.168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Friedman R., Gallo G. R., Buxbaum J. N. Renal disease in rheumatoid arthritis. Arthritis Rheum. 1980 Jun;23(6):781–783. doi: 10.1002/art.1780230614. [DOI] [PubMed] [Google Scholar]
  10. Glassock R. J. A clinical and immunopathologic dissection of rapidly progressive glomerulonephritis. Nephron. 1978;22(1-3):253–264. doi: 10.1159/000181457. [DOI] [PubMed] [Google Scholar]
  11. Glenner G. G. Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts). N Engl J Med. 1980 Jun 12;302(24):1333–1343. doi: 10.1056/NEJM198006123022403. [DOI] [PubMed] [Google Scholar]
  12. Hordon L. D., Sellars L., Morley A. R., Wilkinson R., Thompson M., Griffiths I. D. Haematuria in rheumatoid arthritis: an association with mesangial glomerulonephritis. Ann Rheum Dis. 1984 Jun;43(3):440–443. doi: 10.1136/ard.43.3.440. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. KEMPER J. W., BAGGENSTOSS A. H., SLOCUMB C. H. The relationship of therapy with cortisone to the incidence of vascular lesions in rheumatoid arthritis. Ann Intern Med. 1957 May;46(5):831–851. doi: 10.7326/0003-4819-46-5-831. [DOI] [PubMed] [Google Scholar]
  14. Laakso M., Mutru O., Isomäki H., Koota K. Mortality from amyloidosis and renal diseases in patients with rheumatoid arthritis. Ann Rheum Dis. 1986 Aug;45(8):663–667. doi: 10.1136/ard.45.8.663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Lawson A. A., Maclean N. Renal disease and drug therapy in rheumatoid arthritis. Ann Rheum Dis. 1966 Sep;25(5):441–449. doi: 10.1136/ard.25.5.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mutru O., Koota K., Isomäki H. Causes of death in autopsied RA patients. Scand J Rheumatol. 1976;5(4):239–240. doi: 10.3109/03009747609099912. [DOI] [PubMed] [Google Scholar]
  17. POLLAK V. E., PIRANI C. L., STECK I. E., KARK R. M. The kidney in rheumatoid arthritis: studies by renal biopsy. Arthritis Rheum. 1962 Feb;5:1–9. doi: 10.1002/art.1780050102. [DOI] [PubMed] [Google Scholar]
  18. Pasternack A., Wegelius O., Mäkisara P. Renal biopsy in rheumatoid arthritis. Acta Med Scand. 1967 Nov;182(5):591–595. doi: 10.1111/j.0954-6820.1967.tb10885.x. [DOI] [PubMed] [Google Scholar]
  19. SCHMID F. R., COOPER N. S., ZIFF M., McEWEN C. Arteritis in rheumatoid arthritis. Am J Med. 1961 Jan;30:56–83. doi: 10.1016/0002-9343(61)90064-x. [DOI] [PubMed] [Google Scholar]
  20. Salomon M. I., Gallo G., Poon T. P., Goldblat M. V., Tchertkoff V. The kidney in rheumatoid arthritis. A study based on renal biopsies. Nephron. 1974;12(4):297–310. doi: 10.1159/000180342. [DOI] [PubMed] [Google Scholar]
  21. Samuels B., Lee J. C., Engleman E. P., Hopper J., Jr Membranous nephropathy in patients with rheumatoid arthritis: relationship to gold therapy. Medicine (Baltimore) 1978 Jul;57(4):319–327. doi: 10.1097/00005792-197807000-00003. [DOI] [PubMed] [Google Scholar]
  22. Scott D. G., Bacon P. A., Tribe C. R. Systemic rheumatoid vasculitis: a clinical and laboratory study of 50 cases. Medicine (Baltimore) 1981 Jul;60(4):288–297. [PubMed] [Google Scholar]
  23. Sellars L., Siamopoulos K., Wilkinson R., Leohapand T., Morley A. R. Renal biopsy appearances in rheumatoid disease. Clin Nephrol. 1983 Sep;20(3):114–120. [PubMed] [Google Scholar]
  24. Skrifvars B. V., Törnroth T. S., Tallqvist G. N. Gold-induced immune complex nephritis in seronegative rheumatoid arthritis. Ann Rheum Dis. 1977 Dec;36(6):549–556. doi: 10.1136/ard.36.6.549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Tracy R. E., Tabares Toca V. Nephrosclerosis and blood pressure. II. Reversibility of proliferative arteriosclerosis. Lab Invest. 1974 Jan;30(1):30–34. [PubMed] [Google Scholar]

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