Abstract
Drug use during pregnancy can have detrimental effects--both nonspecific and highly specific--on the perinatal outcome. Nonspecific effects include fetal growth retardation, resulting in small infants and decreased head circumference. Specific effects include facial dysmorphology and organ system anomalies such as alcohol-related birth defects. Patients abusing drugs are at an increased risk for preterm labor, thereby placing an already compromised fetus at increased risk. The number of mothers and infants being infected by the human immunodeficiency virus from sharing needles, multiple sexual contacts, and mother-to-infant transmission is increasing at an alarming rate.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bauchner H., Zuckerman B., McClain M., Frank D., Fried L. E., Kayne H. Risk of sudden infant death syndrome among infants with in utero exposure to cocaine. J Pediatr. 1988 Nov;113(5):831–834. doi: 10.1016/s0022-3476(88)80009-x. [DOI] [PubMed] [Google Scholar]
- Bauman P. S., Levine S. A. The development of children of drug addicts. Int J Addict. 1986 Aug;21(8):849–863. doi: 10.3109/10826088609027399. [DOI] [PubMed] [Google Scholar]
- Bell N. K. AIDS and women: remaining ethical issues. AIDS Educ Prev. 1989 Spring;1(1):22–30. [PubMed] [Google Scholar]
- Bernstein V., Jeremy R. J., Hans S. L., Marcus J. A longitudinal study of offspring born to methadone-maintained women. II. Dyadic interaction and infant behavior at 4 months. Am J Drug Alcohol Abuse. 1984;10(2):161–193. doi: 10.3109/00952998409002779. [DOI] [PubMed] [Google Scholar]
- Bingol N., Fuchs M., Diaz V., Stone R. K., Gromisch D. S. Teratogenicity of cocaine in humans. J Pediatr. 1987 Jan;110(1):93–96. doi: 10.1016/s0022-3476(87)80297-4. [DOI] [PubMed] [Google Scholar]
- Blanche S., Rouzioux C., Moscato M. L., Veber F., Mayaux M. J., Jacomet C., Tricoire J., Deville A., Vial M., Firtion G. A prospective study of infants born to women seropositive for human immunodeficiency virus type 1. HIV Infection in Newborns French Collaborative Study Group. N Engl J Med. 1989 Jun 22;320(25):1643–1648. doi: 10.1056/NEJM198906223202502. [DOI] [PubMed] [Google Scholar]
- Chaney N. E., Franke J., Wadlington W. B. Cocaine convulsions in a breast-feeding baby. J Pediatr. 1988 Jan;112(1):134–135. doi: 10.1016/s0022-3476(88)80139-2. [DOI] [PubMed] [Google Scholar]
- Chasnoff I. J., Burns K. A., Burns W. J. Cocaine use in pregnancy: perinatal morbidity and mortality. Neurotoxicol Teratol. 1987 Jul-Aug;9(4):291–293. doi: 10.1016/0892-0362(87)90017-1. [DOI] [PubMed] [Google Scholar]
- Chasnoff I. J., Burns K. A., Burns W. J., Schnoll S. H. Prenatal drug exposure: effects on neonatal and infant growth and development. Neurobehav Toxicol Teratol. 1986 Jul-Aug;8(4):357–362. [PubMed] [Google Scholar]
- Chasnoff I. J., Burns W. J., Schnoll S. H., Burns K. A. Cocaine use in pregnancy. N Engl J Med. 1985 Sep 12;313(11):666–669. doi: 10.1056/NEJM198509123131105. [DOI] [PubMed] [Google Scholar]
- Chasnoff I. J., Burns W. J., Schnoll S. H. Perinatal addiction: the effects of maternal narcotic and nonnarcotic substance abuse on the fetus and neonate. NIDA Res Monogr. 1984 Mar;49:220–226. [PubMed] [Google Scholar]
- Chasnoff I. J., Bussey M. E., Savich R., Stack C. M. Perinatal cerebral infarction and maternal cocaine use. J Pediatr. 1986 Mar;108(3):456–459. doi: 10.1016/s0022-3476(86)80896-4. [DOI] [PubMed] [Google Scholar]
- Chasnoff I. J., Chisum G. M., Kaplan W. E. Maternal cocaine use and genitourinary tract malformations. Teratology. 1988 Mar;37(3):201–204. doi: 10.1002/tera.1420370304. [DOI] [PubMed] [Google Scholar]
- Chasnoff I. J., Griffith D. R., MacGregor S., Dirkes K., Burns K. A. Temporal patterns of cocaine use in pregnancy. Perinatal outcome. JAMA. 1989 Mar 24;261(12):1741–1744. [PubMed] [Google Scholar]
- Chasnoff I. J., Hunt C. E., Kletter R., Kaplan D. Prenatal cocaine exposure is associated with respiratory pattern abnormalities. Am J Dis Child. 1989 May;143(5):583–587. doi: 10.1001/archpedi.1989.02150170085028. [DOI] [PubMed] [Google Scholar]
- Chasnoff I. J., Lewis D. E., Squires L. Cocaine intoxication in a breast-fed infant. Pediatrics. 1987 Dec;80(6):836–838. [PubMed] [Google Scholar]
- Chasnoff I. J., Schnoll S. H., Burns W. J., Burns K. Maternal nonnarcotic substance abuse during pregnancy: effects on infant development. Neurobehav Toxicol Teratol. 1984 Jul-Aug;6(4):277–280. [PubMed] [Google Scholar]
- Day N. L., Jasperse D., Richardson G., Robles N., Sambamoorthi U., Taylor P., Scher M., Stoffer D., Cornelius M. Prenatal exposure to alcohol: effect on infant growth and morphologic characteristics. Pediatrics. 1989 Sep;84(3):536–541. [PubMed] [Google Scholar]
- Des Jarlais D. C., Friedman S. R., Novick D. M., Sotheran J. L., Thomas P., Yancovitz S. R., Mildvan D., Weber J., Kreek M. J., Maslansky R. HIV-1 infection among intravenous drug users in Manhattan, New York City, from 1977 through 1987. JAMA. 1989 Feb 17;261(7):1008–1012. doi: 10.1001/jama.261.7.1008. [DOI] [PubMed] [Google Scholar]
- Ernhart C. B., Sokol R. J., Ager J. W., Morrow-Tlucak M., Martier S. Alcohol-related birth defects: assessing the risk. Ann N Y Acad Sci. 1989;562:159–172. doi: 10.1111/j.1749-6632.1989.tb21014.x. [DOI] [PubMed] [Google Scholar]
- Frank D. A., Zuckerman B. S., Amaro H., Aboagye K., Bauchner H., Cabral H., Fried L., Hingson R., Kayne H., Levenson S. M. Cocaine use during pregnancy: prevalence and correlates. Pediatrics. 1988 Dec;82(6):888–895. [PubMed] [Google Scholar]
- Graham J. M., Jr, Hanson J. W., Darby B. L., Barr H. M., Streissguth A. P. Independent dysmorphology evaluations at birth and 4 years of age for children exposed to varying amounts of alcohol in utero. Pediatrics. 1988 Jun;81(6):772–778. [PubMed] [Google Scholar]
- Hadeed A. J., Siegel S. R. Maternal cocaine use during pregnancy: effect on the newborn infant. Pediatrics. 1989 Aug;84(2):205–210. [PubMed] [Google Scholar]
- Hayford S. M., Epps R. P., Dahl-Regis M. Behavior and development patterns in children born to heroin-addicted and methadone-addicted mothers. J Natl Med Assoc. 1988 Nov;80(11):1197–1200. [PMC free article] [PubMed] [Google Scholar]
- Jeremy R. J., Bernstein V. J. Dyads at risk: methadone-maintained women and their four-month-old infants. Child Dev. 1984 Aug;55(4):1141–1154. [PubMed] [Google Scholar]
- Johnson J. P., Nair P., Hines S. E., Seiden S. W., Alger L., Revie D. R., O'Neil K. M., Hebel R. Natural history and serologic diagnosis of infants born to human immunodeficiency virus-infected women. Am J Dis Child. 1989 Oct;143(10):1147–1153. doi: 10.1001/archpedi.1989.02150220037017. [DOI] [PubMed] [Google Scholar]
- Kandall S. R., Doberczak T. M., Mauer K. R., Strashun R. H., Korts D. C. Opiate v CNS depressant therapy in neonatal drug abstinence syndrome. Am J Dis Child. 1983 Apr;137(4):378–382. doi: 10.1001/archpedi.1983.02140300056015. [DOI] [PubMed] [Google Scholar]
- Landesman S. H., Minkoff H. L., Willoughby A. HIV disease in reproductive age women: a problem of the present. JAMA. 1989 Mar 3;261(9):1326–1327. [PubMed] [Google Scholar]
- Little R. E., Anderson K. W., Ervin C. H., Worthington-Roberts B., Clarren S. K. Maternal alcohol use during breast-feeding and infant mental and motor development at one year. N Engl J Med. 1989 Aug 17;321(7):425–430. doi: 10.1056/NEJM198908173210703. [DOI] [PubMed] [Google Scholar]
- Mills J. L., Graubard B. I. Is moderate drinking during pregnancy associated with an increased risk for malformations? Pediatrics. 1987 Sep;80(3):309–314. [PubMed] [Google Scholar]
- Mondanaro J. Strategies for AIDS prevention: motivating health behavior in drug dependent women. J Psychoactive Drugs. 1987 Apr-Jun;19(2):143–149. doi: 10.1080/02791072.1987.10472398. [DOI] [PubMed] [Google Scholar]
- Novello A. C., Wise P. H., Willoughby A., Pizzo P. A. Final report of the United States Department of Health and Human Services Secretary's Work Group on pediatric human immunodeficiency virus infection and disease: content and implications. Pediatrics. 1989 Sep;84(3):547–555. [PubMed] [Google Scholar]
- Ochs H. D. The human immunodeficiency virus-infected infant. A diagnostic dilemma. Am J Dis Child. 1989 Oct;143(10):1138–1139. doi: 10.1001/archpedi.1989.02150220026013. [DOI] [PubMed] [Google Scholar]
- Rosen T. S., Johnson H. L. Children of methadone-maintained mothers: follow-up to 18 months of age. J Pediatr. 1982 Aug;101(2):192–196. doi: 10.1016/s0022-3476(82)80115-7. [DOI] [PubMed] [Google Scholar]
- Selwyn P. A., Schoenbaum E. E., Davenny K., Robertson V. J., Feingold A. R., Shulman J. F., Mayers M. M., Klein R. S., Friedland G. H., Rogers M. F. Prospective study of human immunodeficiency virus infection and pregnancy outcomes in intravenous drug users. JAMA. 1989 Mar 3;261(9):1289–1294. [PubMed] [Google Scholar]
- Streissguth A. P., Sampson P. D., Barr H. M. Neurobehavioral dose-response effects of prenatal alcohol exposure in humans from infancy to adulthood. Ann N Y Acad Sci. 1989;562:145–158. doi: 10.1111/j.1749-6632.1989.tb21013.x. [DOI] [PubMed] [Google Scholar]
- Toubas P. L., Duke J. C., McCaffree M. A., Mattice C. D., Bendell D., Orr W. C. Effects of maternal smoking and caffeine habits on infantile apnea: a retrospective study. Pediatrics. 1986 Jul;78(1):159–163. [PubMed] [Google Scholar]
- Weisberg E. Smoking and reproductive health. Clin Reprod Fertil. 1985 Sep;3(3):175–186. [PubMed] [Google Scholar]
- Wilson G. S. Clinical studies of infants and children exposed prenatally to heroin. Ann N Y Acad Sci. 1989;562:183–194. doi: 10.1111/j.1749-6632.1989.tb21017.x. [DOI] [PubMed] [Google Scholar]
- van Baar A. L., Fleury P., Ultee C. A. Behaviour in first year after drug dependent pregnancy. Arch Dis Child. 1989 Feb;64(2):241–245. doi: 10.1136/adc.64.2.241. [DOI] [PMC free article] [PubMed] [Google Scholar]