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. 2023 Mar 18;12(1):16. doi: 10.1038/s41389-023-00460-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Inhibition of FASN by orlistat induces NK cells and CD8⁺ T cells activation. Orlistat decreases the amount of T-regs whose suppressive activity is in part induced by FASN. Orlistat decreases PD-L1 expression, induces the secretion of nitric oxide (NO) by neutrophils and decreases the pool of fatty acids in dendritic cells which increases their maturation. The inhibition of FASN by C75 indirectly decreases the number of M2 macrophages but increases the pool of extracellular fatty acids that probably attract NK and CD4⁺/CD8⁺ T cells in the tumor microenvironnement. FASN is therefore involved in immune escape. The dotted arrows represent an indirect effect.