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. 2021 Aug 18;29:104694. doi: 10.1016/j.rinp.2021.104694

Modeling third waves of Covid-19 spread with piecewise differential and integral operators: Turkey, Spain and Czechia

Abdon Atangana a,b,1, Seda İğret Araz a,c,⁎,1
PMCID: PMC10025579  PMID: 36968003

Abstract

Several collected data representing the spread of some infectious diseases have demonstrated that the spread does not really exhibit homogeneous spread. Clear examples can include the spread of Spanish flu and Covid-19. Collected data depicting numbers of daily new infections in the case of Covid-19 from countries like Turkey, Spain show three waves with different spread patterns, a clear indication of crossover behaviors. While modelers have suggested many mathematical models to depicting these behaviors, it becomes clear that their mathematical models cannot really capture the crossover behaviors, especially passage from deterministic resetting to stochastics. Very recently Atangana and Seda have suggested a concept of piecewise modeling consisting in defining a differential operator piece-wisely. The idea was first applied in chaos and outstanding patterns were captured. In this paper, we extend this concept to the field of epidemiology with the aim to depict waves with different patterns. Due to the novelty of this concept, a different approach to insure the existence and uniqueness of system solutions are presented. A piecewise numerical approach is presented to derive numerical solutions of such models. An illustrative example is presented and compared with collected data from 3 different countries including Turkey, Spain and Czechia. The obtained results let no doubt for us to conclude that this concept is a new window that will help mankind to better understand nature.

Keywords: Piecewise modeling, Piecewise existence and uniqueness, Piecewise numerical scheme, Covid-19 model, Fractional operators and stochastic approach

Introduction

Although mankind has been using mathematical models to attempt replicating the spread patterns of infection diseases within given settlements, however in several cases, one will notice that their mathematical models do not always capture the waves and the different crossovers exhibiting by these waves [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]. Some examples including the Spanish flu that started in 1918 and ended after three waves in 1920. Another-recent one is the spread of Covid-19 [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]. The disagreement between experimental data and the solutions of mathematical equation are perhaps since complexities of collected data are not sometimes considered. Another reason is perhaps the non-updating of existing theory, for example, many years the reproductive number have been used in many research papers with no new modification , indeed, the reproductive number may not be able to tell beforehand if a disease will have waves or not. Another example is the use of rates that have been always suggested to be constant, white a constant rate clearly show the homogeneity of the spread. Whereas in the normal situation rate of infection could be a function of time to indeed include into the mathematical equation the spread complexities or non-homogeneity. Another quite useful function to evaluate the stability of equilibrium point is the Lyapunov function. Such function cannot however inform about the wave and their patterns. Recorded data of Covid-19 spread of some countries show multiple waves. For example, collected data from Turkey, Czechia and Spain show three waves at least, where each wave presents a different process. Neither the concept of reproductive number or the Lyapunov function or the existing way of modelling epidemiological problems could possibly predict these waves. Indeed, modelling real world problems with crossover effects has always been a great challenge to modelers. Even though significant efforts have been made by researchers from different background, nevertheless there are still many real world problems exhibiting crossover behaviours with complex patterns. An effort made to address this resulted to an introduction of a fractional differential operators with non-singular kernel exhibiting a crossover from stretched exponential to power-law in terms of mean-square displacement. This non-singular kernel also has crossover from normal to sub-diffusion, also, the kernel can express crossover from random walk to power-law. However, crossover from deterministic setting to stochastic or from stochastic to deterministic cannot be captured by this kernel, thus a great limitation of such operators to be used in these scenarios [13], [14], [15], [16].

Very recently, Atangana and Seda suggested the concepts of piecewise differential and integral operators. Additionally, the extended their innovative idea to modelling by suggesting a piecewise modelling. This idea is perhaps the future of modelling with this innovative idea, we suggest in this paper a new way to model epidemiological problems exhibiting crossover behaviours. In this paper, two illustrative examples will be presented. We will assume that real world spread exhibit three waves with different patterns, classical, nonlocal and randomness, a permutation can be done to have different behaviours based on the above processes.

Modeling spread of infectious diseases with waves

In this section, we present a new way to model spread of infectious diseases exhibiting waves with different patterns. Let assume without loss of generality that a mathematical model with n classes describes spread of an infectious diseases with three waves where each wave exhibits different patterns, assume with no loss of generality that classical mechanical processes, non-local processes, randomnessly and their permutation, which will be considered in different cases. It is worth noting that in a real world problem where different waves or patterns are observed collected data will guide the choice piecewise differential operators. In this section, however, we suggest theoretically for illustration the order of patterns. This will be presented in several cases.

Case 1: Classical-power-law-randomness

In this case, we assume a scenario where the three waves of the spread exhibit the above processes. We assume that the first process starts from 0 to T1, the second from T1 to T2, and the last from T2 to T. A piecewise mathematical model associate to this can be given as

dXitdt=ft,Xi, if 0tT1Xi0=Xi,0,i=1,2,,nT1CDtαXit=ft,Xi, if T1tT2XiT1=Xi,1,0<α1,i=1,2,,ndXit=ft,Xidt+σiXidBit , if T2tTXiT2=Xi,2,i=1,2,,n (1)

where σi are densities of randomness and Bi are the functions of noise.

Case 2: Classical-Mittag-Leffler law-randomness

In this case, we assume a scenario where the three waves present processes with classical behaviors, passage from stretched exponential to power-law and randomness, within the intervals described earlier in Case (1). A piecewise model associate to the above scenarios can be given as

dXitdt=ft,Xi, if 0tT1Xi0=Xi,0,i=1,2,,nT1ABCDtαXit=ft,Xi, if T1tT2XiT1=Xi,1,0<α1,i=1,2,,ndXit=ft,Xidt+σiXidBit , if T2tTXiT2=Xi,2,i=1,2,,n (2)

Case 3: Classical-fading memory-randomness

In this case, it is assumed that three waves are observed where the second wave displays fading memory process, which was known to be described best with the differential operator with exponential kernel. We also assume that three waves appear in the intervals described in Case (1), then, the mathematical model associate to this scenario is given as:

dXitdt=ft,Xi, if 0tT1Xi0=Xi,0,i=1,2,,nT1CFDtαXit=ft,Xi, if T1tT2XiT1=Xi,1,0<α1,i=1,2,,ndXit=ft,Xidt+σiXidBit , if T2tTXiT2=Xi,2,i=1,2,,n. (3)

It is noted that in Case (1), (2) and (3)

0CDtαXt=1Γ1α0ttταX τdτ,0<α1, (4)
0CFDtαXt=Mα1α0tX τexpα1αtτdτ,0<α1, (5)

where Mα is the normalization function such that M0=M1=1. Also

0ABCDtαXt=ABα1α0tX τ Eαα1αtταdτ,0<α1 (6)

where ABα=1α+αΓα is the normalization function such that AB0=AB1=1.

The analysis regarding the theory of existence and uniqueness will not be discussed here in general. However, this can be achieved within each interval In our paper, we will present existence and uniqueness for some examples. But here, we shall present numerical solution of such model.

Numerical solution of piecewise epidemiological model

Assuming that the described models satisfy theoretical aspects of existence and uniqueness. Thus in this section, we present numerical solutions. We shall use in all cases based on the Newton polynomial interpolation [23].

Numerical method for Case 1

We consider the first Case

dXitdt=ft,Xi, if 0tT1Xi0=Xi,0,i=1,2,,nT1CDtαXit=ft,Xi, if T1tT2XiT1=Xi,1,dXit=ft,Xidt+σiXidBit , if T2tTXiT2=Xi,2. (7)

We divide 0,T in three

0t0t1tn1=T1tn1+1tn1+2tn2=T2tn2+1tn2+2...tn3=T (8)

The numerical solution can then be provided as

Xin1=Xi0+j1=2n12312ftj1,Xj143ftj11,Xj11+512ftj12,Xj12Δt,0tT1Xin2=XiT1+ΔtΓα+1j2=n1+3n2ftj22,Xj22×n2j2+1αn2j2α+ΔtΓα+2j2=n1+3n2ftj21,Xj21ftj22,Xj22×n2j2+1αn2j2+3+2αn2j2αn2j2+3+3α+Δt2Γα+3j2=n1+3n2ftj2,Xj22ftj21,Xj21+ftj22,Xj22×n2j2+1α2n2j22+3α+10n2j2+2α2+9α+12n2j2α2n2j22+5α+10n2j2+6α2+18α+12,T1tT2Xin3=XiT2+j3=n2+3n32312ftj3,Xj343ftj31,Xj31+512ftj32,Xj32Δt+σij=n2+3n3Xij3Bij3Bij31,T2tT. (9)

Numerical method for Case 2

We deal with the following problem with second Case

dXitdt=ft,Xi, if 0tT1Xi0=Xi,0,i=1,2,,nT1ABCDtαXit=ft,Xi, if T1tT2XiT1=Xi,1,dXit=ft,Xidt+σiXidBit , if T2tTXiT2=Xi,2. (10)

The numerical solution for such problem is given by

Xin1=Xi0+j1=2n12312ftj1,Xj143ftj11,Xj11+512ftj12,Xj12Δt,0tT1Xin2=XiT1+1αMαftn2,Xn2ftn21,Xn21,T1tT2+αMαj2=n1+3n22312ftj2,Xj243ftj21,Xj21+512ftj22,Xj22ΔtXin3=XiT2+j3=n2+3n32312ftj3,Xj343ftj31,Xj31+512ftj32,Xj32Δt+σij=n2+3n3Xij3Bij3Bij31,T2tT. (11)

Numerical method for Case 3

We consider the following problem with third Case

dXitdt=ft,Xi, if 0tT1Xi0=Xi,0,i=1,2,,nT1ABCDtαXit=ft,Xi, if T1tT2XiT1=Xi,1,dXit=ft,Xidt+σiXidBit , if T2tTXiT2=Xi,2. (12)

Using same routine, the numerical solution can be obtained as

Xin1=Xi0+j1=2n12312ftj1,Xj143ftj11,Xj11+512ftj12,Xj12Δt,0tT1Xin2=XiT1+1αABαftn2,Xn2+αΔtABαΓα+1×j2=n1+3n2ftj22,Xj22n2j2+1αn2j2α+αΔtABαΓα+2j2=n1+3n2ftj21,Xj21ftj22,Xj22×n2j2+1αn2j2+3+2αn2j2αn2j2+3+3α+αΔt2ABαΓα+3j2=n1+3n2ftj2,Xj22ftj21,Xj21+ftj22,Xj22×n2j2+1α2n2j22+3α+10n2j2+2α2+9α+12n2j2α2n2j22+5α+10n2j2+6α2+18α+12,T1tT2Xin3=XiT2+j3=n2+3n32312ftj3,Xj343ftj31,Xj31+512ftj32,Xj32Δt+σij=n2+3n3Xij3Bij3Bij31,T2tT. (13)

A mathematical model of Covid-19 spread with piecewise modeling

In this section, we consider a mathematical model of Covid-19 spread introduced in [11] and modify it by piecewise differential operators. Such model can be considered as (see Table 1);

dSdt=Λbt+bqsQbsq+λSdEdt=btβ+beq+λEdIdt=βEδ+λ+bicIdQdt=bsqS+beqEbqs+bqc+λQdCdt=bqcQ+bicIδ+bcr+λCdRdt=bcrCλRdWdt=k1E+k2IλwW if 0tT1
T1CDtαS=Λbt+bqsQbsq+λST1CDtαE=btβ+beq+λET1CDtαI=βEδ+λ+bicIT1CDtαQ=bsqS+beqEbqs+bqc+λQT1CDtαC=bqcQ+bicIδ+bcr+λCT1CDtαR=bcrCλRT1CDtαW=k1E+k2IλwW if T1tT2
dS=Λbt+bqsQbsq+λSdt+σ1SdB1tdE=btβ+beq+λEdt+σ2EdB2tdI=βEδ+λ+bicIdt+σ3IdB3tdQ=bsqS+beqEbqs+bqc+λQdt+σ4QdB4tdC=bqcQ+bicIδ+bcr+λCdt+σ5CdB5tdR=bcrCλRdt+σ6RdB6tdW=k1E+k2IλwWdt+σ7WdB7t if T2tT

where

bt=αE1+vESE+αI1+vISI+αW1+vWSW. (14)

The function St is the number of individuals susceptible to infection at a given time t. The function Et is the number of individuals infected but without symptoms at a given time t. The function It is the number of individuals infected but not yet isolated at a given time t. The function Qt is the number of individuals quarantined at a given time t. The function Ct is the number of individuals confirmed to be infected with the virus, isolated and expecting recovery at a given time t. The function Rt is the number of individuals recovered at a given time t. The function Wt is the concentration of the virus in the environmental reservoir. The initial conditions are

S0=S0,E0=E0,I0=I0,Q0=Q0,C0=C0,R0=R0,W0=W0. (15)

Table 1.

Parameters of the suggested Covid-19 model.

Λ : Birth rate
λ : Natural mortality rate
δ : The disease-induced fatality rate
β1 : The incubation period between the infected and the onset of symptoms
bcr : The rate of recovery from the infectious disease
bic : The rate at which highly infectious individuals are confirmed
bsq : The rate at which susceptible are quarantined
beq : The rate at which exposed are quarantined
bqc : The rate at which quarantine individuals are confirmed
bqs : The rate at which quarantined move back to the susceptible class
k1 : The rate at which the exposed contribute the disease to the environmental reservoir
k2 : The rate at which the infected contribute the disease to the environmental reservoir
λw : Rate of removal of the virus from the environmental reservoir
N : Total population
αE : Transmission rate from the exposed to the susceptible
αI : Transmission rate from the highly infected to the susceptible
αW : Transmission rate from the environmental reservoir to the susceptible
v : Coefficient providing adjustment to the transmission rate

Existence and uniqueness of Covid-19 model

In this section, we attempt to present a proof of existence and uniqueness of system solution of this model. However, we shall note that, different techniques will be applied in respect to each interval, indeed for the first and second Case, the well-known procedure using the Banach fixed-point theorem or modified versions will be applied, however, the last part, since concerning stochastic a different technique is applied.

dSdt=Λbt+bqsQbsq+λSdEdt=btβ+beq+λEdIdt=βEδ+λ+bicIdQdt=bsqS+beqEbqs+bqc+λQdCdt=bqcQ+bicIδ+bcr+λCdRdt=bcrCλRdWdt=k1E+k2IλwW if 0tT1
T1CDtαS=Λbt+bqsQbsq+λST1CDtαE=btβ+beq+λET1CDtαI=βEδ+λ+bicIT1CDtαQ=bsqS+beqEbqs+bqc+λQT1CDtαC=bqcQ+bicIδ+bcr+λCT1CDtαR=bcrCλRT1CDtαW=k1E+k2IλwW if T1tT2
dS=Λbt+bqsQbsq+λSdt+σ1SdB1tdE=btβ+beq+λEdt+σ2EdB2tdI=βEδ+λ+bicIdt+σ3IdB3tdQ=bsqS+beqEbqs+bqc+λQdt+σ4QdB4tdC=bqcQ+bicIδ+bcr+λCdt+σ5CdB5tdR=bcrCλRdt+σ6RdB6tdW=k1E+k2IλwWdt+σ7WdB7t if T2tT.

We now present the existence and uniqueness of the piecewise model. For simplicity, we write subject to X=S,E,I,Q,C,R,W

dXtdt=fX,t if 0tT1 (16)
T1CDtαXt=ft,X if T1tT2
dXt=fX,tdt+σXdBt if T2tT

where

f=f1,f2,f3,f4,f5,f6,f7,σ=σ1,σ2,σ3,σ4,σ5,σ6,σ7,
Bt=B1t,B2t,B3t,B4t,B5t,B6t,B7t. (17)

To show the existence and uniqueness, we shall prove that 0,T1 and T1,T2, fiX,t satisfy

  • 1.

    Linear growth condition

  • 2.

    The Lipschitz condition.

tT2,T, another methodology will be adopted.

For proof, we consider for tT2,T.

Since all the used parameters of our model a positive constant, thus, they are continuous in Lipschitz sense for a given initial size of population XtR+7, one can find a unique local solution. XtT2,τe, where τe denotes explosion time. To insure the solution is global, one has to prove that such system solution is global, we should prove that τe=. To achieve our goal, we consider k0R+ is a positive constant such that XT2 lies within 1k0,k0. Additionally, we define a stopping time

τk=tT2,τe:1kminXt or maxXtk (18)

for each kk0.

τk is monotonically increasing as k. limkτk=τ with τeτ. t0, if we show that τ=0, then we can conclude that τe= and XtR+7 is solution. To achieve that we have to prove that τe=. Nevertheless if the conclusion is contradictory, then there exists 0<T and ξ0,1 such that

PTτ>ξ. (19)

We additionally define a function λ¯:R+7R+ in λC2 space such that

λ¯Xt=i=17xi7i=17logxi. (20)

Owning the fact that z>0,z1logz0, this leads to λ¯0. Additionally, it is assumed that k0<k and 0<T, therefore a direct application of Ito formula leads to

dλ¯X=j=1711xjdxj+σjxj1dBjt=j=1711xjxj+j=17σjxj1dBjt. (21)

Here

HX=j=1711xjxj=11SΛbt+bqsQbsq+λS (22)
+11Ebtβ+beq+λE+11IβEδ+λ+bicI+11QbsqS+beqEbqs+bqc+λQ+11CbqcQ+bicIδ+bcr+λC+11R bcrCλR+11Wk1E+k2IλwW+j=17σj22.

Then

HX=Λ+bqsQ+btS+bsq+λ+bt+β+beq+λ+βE+δ (23)
+λ+bic+bsqS+beqE+bqs+bqc+λ+bqcQ+bicI+δ+bcr+λ+bcrC+λ+k1E+k2I+λwΛS+bt+bqsQS+bsq+λS+btE+β+beq+λE+βEI+δ+λ+bicI+bqs+bqc+λQ+bsqS+beqEQ+δ+bcr+λC+bqcQ+bicIC+λR+bcrCR+λwW+k1E+k2IW+j=17σj22<Λ+bsq+6λ+β+beq+δ+bic+bqs+bqc+δ+bcr+λw=ϕ¯

and

dλ¯X=ϕ¯dt+j=17σjxj1dBjt. (24)

By direct integration from 0 to τkT, we have

Eλ¯τkXλ¯XT2+E0τkTϕ¯λ¯XT2+ϕ¯T. (25)

Setting Πk=T>τk for k1k and thus PΠkξ. Noting that for ΩΠk, there must exist at least one Xτk,w which is equal to 1k or k. Then klogk1 or 1k+logk1 as result

logk+1k1Eklogk1<λ¯Xτk. (26)

From above, we can write

λ¯XT2+ϕ¯T>E1Πkλ¯Xτkσklogk1logk+1k1. (27)

Here 1Πk is the indicator function of Π. Thus limk leads

>λ¯XT2+ϕ¯T=0, (28)

which is a contradiction. Therefore under the conditions presented earlier τ= which completes the proof. Within 0,T2 we show that 0,T2,i=1,2,,7

|fixi,t|2ki1+|xi|2 (29)

and

|fixi1,tfixi2,t|2k¯i|xi1xi2|2. (30)

For t0,T, we have

|F1S,E,I,Q,C,R,W,t|2
=|Λbt+bqsQbsq+λS|2 (31)
4Λ2+|bt|2+bqs2|Q|2+bsq+λ2|S|24Λ2+sup0tT|bt|2+bqs2sup0tT|Q|2+bsq+λ2|S|24Λ2+3v2αE2+αI2+αW2|S|2+bqs2Q2+bsq+λ2|S|24K1+3v2αE2+αI2+αW2+bsq+λ2K|S|2k11+|S|2

where K=Λ2+bqs2Q2 and under the condition 3v2αE2+αI2+αW2+bsq+λ2K<1. For t0,T, we get

|F2S,E,I,Q,C,R,W,t|2
=|btβ+beq+λE|2 (32)
2|bt|2+2β+beq+λ2|E|26v2αE2+αI2+αW2sup0tT|S2|+2β+beq+λ2|E|26v2αE2+αI2+αW2S2+2β+beq+λ2|E|26v2αE2+αI2+αW2S21+2β+beq+λ26v2αE2+αI2+αW2S2|E|2k21+|E|2

if 2β+beq+λ26v2αE2+αI2+αW2S2<1.

|F3S,E,I,Q,C,R,W,t|2=|βEδ+λ+bicI|2 (33)
2β2|E|2+2δ+λ+bic2|I|22β2sup0tT|E2|+2δ+λ+bic2|I|22β2E2+2δ+λ+bic2|I|22β2E21+2δ+λ+bic22β2E2|I|2k31+|I|2

if δ+λ+bic2β2E2<1.

|F4S,E,I,Q,C,R,W,t|2=|bsqS+beqEbqs+bqc+λQ|2 (34)
3bsq2|S|2+3beq2|E|2+3bqs+bqc+λ2|Q|23bsq2sup0tT|S2|+3beq2sup0tT|E2|+3bqs+bqc+λ2|Q|23bsq2S2+3beq2E2+3bqs+bqc+λ2|Q|23bsq2S2+beq2E21+3bqs+bqc+λ23bsq2S2+beq2E2|Q|2k41+|Q|2

under the condition bqs+bqc+λ2bsq2S2+beq2E2<1.

|F5S,E,I,Q,C,R,W,t|2
=|bqcQ+bicIδ+bcr+λC|2 (35)
3bqc2|Q|2+3bic2|I|2+3δ+bcr+λ2|C|23bqc2sup0tT|Q2|+3bic2sup0tT|I2|+3δ+bcr+λ2|C|23bqc2Q2+3bic2I2+3δ+bcr+λ2|C|23bqc2Q2+bic2I21+3δ+bcr+λ23bqc2Q2+3bic2I2|C|2k51+|C|2

if δ+bcr+λ2bqc2Q2+bic2I2<1.

|F6S,E,I,Q,C,R,W,t|2=|bcrCλR|2 (36)
2bcr2|C|2+2λ2|R|22bcr2sup0tT|C2|+2λ2|R|22bcr2C2+2λ2|R|22bcr2C21+2λ22bcr2C2|R|2k61+|R|2

if λ2bcr2C2<1. Finally, we have

|F7S,E,I,Q,C,R,W,t|2=|k1E+k2IλwW|2 (37)
3k12|E|2+3k22|I|2+3λw2|W|23k12sup0tT|E2|+3k22sup0tT|I2|+3λw2|W|23k12E2+3k22I2+3λw2|W|23k12E2+k22I2×1+3λw23k12E2+3k22I2|W|2k71+|W|2

under the condition λw2k12E2+k22I2<1. To verify second condition, we write

|F1t,S1F1t,S2|223v2αE2+3v2αI2+3v2αW2+bsq+λ2×|S1S2|2 (38)
k¯1|S1S2|2,
|F2t,E1F2t,E2|22αE2|S|2+bsq+λ2|E1E2|2 (39)
2αE2sup0tT|S|2+bsq+λ2|E1E2|22αE2S2+bsq+λ2|E1E2|2k¯2|S1S2|2,
|F3t,I1F3t,I2|2δ+λ+bic2|I1I2|2 (40)
k¯3|I1I2|2,
|F4t,Q1F4t,Q2|2bqs+bqc+λ2|Q1Q2|2 (41)
k¯4|Q1Q2|2,
|F5t,C1F5t,C2|2δ+bcr+λ2|C1C2|2 (42)
k¯5|C1C2|2,
|F6t,R1F6t,R2|2λ2|R1R2|2 (43)
k¯6|R1R2|2,
|F7t,W1F7t,W2|2λw2|W1W2|2 (44)
k¯7|W1W2|2.

Therefore under the condition that

max3v2αE2+αI2+αW2+bsq+λ2K,2β+beq+λ26v2αE2+αI2+αW2S2,δ+λ+bic2β2E2,bqs+bqc+λ2bsq2S2+beq2E2δ+bcr+λ2bqc2Q2+bic2I2,λ2bcr2C2,3λw23k12E2+3k22I2<1. (45)

Then assumed that the solution are positive in 0,T2, then t0,T the piecewise has a unique positive solution.

Applications for Covid-19 model

A demonstrative example is better than precept, therefore, in this section, we present an application of the suggested theory. In particular, we will consider a mathematical model that was suggested to depicting the spread of Covid-19 within a given settlement. The model will be later modified to follow the steps presented in piece-wise modeling and for each model, a numerical method will be used to provide a numerical solution to the model. Numerical simulation using the suggested numerical are performed and depicted in Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6, Fig. 7 for the first Case, Fig. 8, Fig. 9, Fig. 10, Fig. 11, Fig. 12, Fig. 13, Fig. 14, Fig. 15, Fig. 16, Fig. 17, Fig. 18, Fig. 19, Fig. 20, Fig. 21 for second Case and lastly Fig. 22, Fig. 23, Fig. 24, Fig. 25, Fig. 26, Fig. 27, Fig. 28 for third Case.

Fig. 1.

Fig. 1

Numerical visualization for susceptible people for α=0.95.

Fig. 2.

Fig. 2

Numerical visualization for exposed people for α=0.95.

Fig. 3.

Fig. 3

Numerical visualization for infected people for α=0.95.

Fig. 4.

Fig. 4

Numerical visualization for quarantined people for α=0.95.

Fig. 5.

Fig. 5

Numerical visualization for confirmed people for α=0.95.

Fig. 6.

Fig. 6

Numerical visualization for recovered people for α=0.95.

Fig. 7.

Fig. 7

Numerical visualization for concentration of the virus for α=0.95.

Fig. 8.

Fig. 8

Numerical visualization for susceptible people for α=0.95.

Fig. 9.

Fig. 9

Numerical visualization for exposed people for α=0.95.

Fig. 10.

Fig. 10

Numerical visualization for infected people for α=0.95.

Fig. 11.

Fig. 11

Numerical visualization for quarantined people for α=0.95.

Fig. 12.

Fig. 12

Numerical visualization for confirmed people for α=0.95.

Fig. 13.

Fig. 13

Numerical visualization for recovered people for α=0.95.

Fig. 14.

Fig. 14

Numerical visualization for concentration of the virus for α=0.95.

Fig. 15.

Fig. 15

Numerical visualization for susceptible people for α=0.95.

Fig. 16.

Fig. 16

Numerical visualization for exposed people for α=0.95.

Fig. 17.

Fig. 17

Numerical visualization for infected people for α=0.95.

Fig. 18.

Fig. 18

Numerical visualization for quarantined people for α=0.95.

Fig. 19.

Fig. 19

Numerical visualization for confirmed people for α=0.95.

Fig. 20.

Fig. 20

Numerical visualization for recovered people for α=0.95.

Fig. 21.

Fig. 21

Numerical visualization for concentration of the virus for α=0.95.

Fig. 22.

Fig. 22

Numerical visualization for susceptible people for α=0.95.

Fig. 23.

Fig. 23

Numerical visualization for exposed people for α=0.95.

Fig. 24.

Fig. 24

Numerical visualization for infected people for α=0.95.

Fig. 25.

Fig. 25

Numerical visualization for quarantined people for α=0.95.

Fig. 26.

Fig. 26

Numerical visualization for confirmed people for α=0.95.

Fig. 27.

Fig. 27

Numerical visualization for recovered people for α=0.95.

Fig. 28.

Fig. 28

Numerical visualization for concentration of the virus for α=0.95.

Numerical simulation of Covid-19 model for Case 1

In Case 1, we consider a country within which the spread displays three processes, including classical behaviors, power law behavior and finally stochastic behaviors. In this case, if we consider T as the last time of the spread, this is to say, the last day where a new infection occur, then, for the first period of time ranging from 0 to T1, the mathematical model will be constructed with classical differential operator, the second phrase, the model will be with the Caputo-Power law differential operator and finally stochastic approach will be used at the last phase. The mathematical model explaining this dynamic is then presented below.

0CDtαS=Λbt+bqsQbsq+λS0CDtαE=btβ+beq+λE0CDtαI=βEδ+λ+bicI0CDtαQ=bsqS+beqEbqs+bqc+λQ0CDtαC=bqcQ+bicIδ+bcr+λC0CDtαR=bcrCλR0CDtαW=k1E+k2IλwW if 0tT1
dSdt=Λbt+bqsQbsq+λSdEdt=btβ+beq+λEdIdt=βEδ+λ+bicIdQdt=bsqS+beqEbqs+bqc+λQdCdt=bqcQ+bicIδ+bcr+λCdRdt=bcrCλRdWdt=k1E+k2IλwW if T1tT2
dS=Λbt+bqsQbsq+λSdt+σ1SdB1tdE=btβ+beq+λEdt+σ2EdB2tdI=βEδ+λ+bicIdt+σ3IdB3tdQ=bsqS+beqEbqs+bqc+λQdt+σ4QdB4tdC=bqcQ+bicIδ+bcr+λCdt+σ5CdB5tdR=bcrCλRdt+σ6RdB6tdW=k1E+k2IλwWdt+σ7WdB7t if T2tT.

The initial conditions are considered as

S0=1000,E0=80,I0=10,Q0=10,C0=20,
R0=10,W0=10, (46)
ST1=405.2,ST2=302000,ET1=0.0000964,
ET2=139,IT1=69.45,
IT2=10990,QT1=2.851,QT2=2518,
CT1=12.8,CT2=1543,
RT1=11.76,RT2=7310,WT1=228.4,WT2=10390

and the parameters are

Λ=0.0001,N=1000,αE=0.00003366,
αI=0.000006396,αW=0.00001886, (47)
bqs=0.008667,bsq=0.000015,κ=0.0066,λ=0.0182,β=0.5,
beq=0.000004103,bqc=0.0001333,bcr=1/15,k1=0.01,k2=0.235,
λw=0.01,δ=0.0382,bic=0.00626,T1=50,T2=100,σ1=0.08,
σ2=0.0094,σ3=0.082,σ4=0.078,σ5=0.084,σ6=0.079;σ7=0.12.

The numerical simulations for piecewise model are performed in Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6, Fig. 7.

Numerical simulation of Covid-19 model for Case 2

In Case 2, we consider a given community where the spread displays three processes, including classical behaviors, fading memory behavior and finally stochastic behaviors. In this case, if we consider T as the last time of the spread, this is to say, the last day where a new infection occur, then, for the first period of time ranging from 0 to T1, the mathematical model will be constructed with classical differential operator, the second phrase, the model will be with the Caputo–Fabrizio differential operator and finally stochastic approach will be used at the last phase. The mathematical model explaining this dynamic is then presented below.

dSdt=Λbt+bqsQbsq+λSdEdt=btβ+beq+λEdIdt=βEδ+λ+bicIdQdt=bsqS+beqEbqs+bqc+λQdCdt=bqcQ+bicIδ+bcr+λCdRdt=bcrCλRdWdt=k1E+k2IλwW if 0tT1
T1CFDtαS=Λbt+bqsQbsq+λST1CFDtαE=btβ+beq+λET1CFDtαI=βEδ+λ+bicIT1CFDtαQ=bsqS+beqEbqs+bqc+λQT1CFDtαC=bqcQ+bicIδ+bcr+λCT1CFDtαR=bcrCλRT1CFDtαW=k1E+k2IλwW if T1tT2
dS=Λbt+bqsQbsq+λSdt+σ1SdB1tdE=btβ+beq+λEdt+σ2EdB2tdI=βEδ+λ+bicIdt+σ3IdB3tdQ=bsqS+beqEbqs+bqc+λQdt+σ4QdB4tdC=bqcQ+bicIδ+bcr+λCdt+σ5CdB5tdR=bcrCλRdt+σ6RdB6tdW=k1E+k2IλwWdt+σ7WdB7t if T2tT.

The initial conditions are as follows:

S0=1000,E0=20,I0=0,Q0=100,C0=1,
R0=1,W0=1, (48)
ST1=20100,ST2=596300,ET1=1994,
ET2=32340,IT1=80.83,
IT2=611.6,QT1=7960,QT2=120100,
CT1=225,CT2=4419,
RT1=437,RT2=13730,WT1=27.88,WT2=481.2

and the parameters are

Λ=0.00022655,N=1000,αE=0.00003366,αI=0.000006396, (49)
αW=0.00001886,bqs=0.008667,bsq=0.000015,κ=0.0066,
λ=0.0182,β=0.1,beq=0.000004103,bqc=0.1333,
bcr=1/15,k1=0.01,k2=0.0235,λw=1,δ=3.82,bic=0.626, (50)
T1=25,T2=60,σ1=0.08,σ2=0.0094,σ3=0.082,
σ4=0.078,σ5=0.084,σ6=0.079;σ7=0.12.

The numerical simulations of model with piecewise differential and integral operators are performed in Fig. 8, Fig. 9, Fig. 10, Fig. 11, Fig. 12, Fig. 13, Fig. 14.

In Fig. 15, Fig. 16, Fig. 17, Fig. 18, Fig. 19, Fig. 20, Fig. 21, the numerical simulations of model with piecewise derivative are depicted with

S0=1000,E0=20,I0=0,Q0=100,C0=1,
R0=1,W0=1, (51)
ST1=241110,ST2=3190000,ET1=1690,
ET2=27950,IT1=80.83,
IT2=483.3,QT1=6142,QT2=122400,
CT1=225,CT2=4255,
RT1=2332,RT2=15010,WT1=27.88,WT2=313

and the parameters

Λ=0.00022655,N=1000,αE=0.00003366, (52)
αI=0.000006396,αW=0.00001886, (53)
bqs=0.008667,bsq=0.000015,κ=0.0066,λ=0.0182,
β=0.1,beq=0.000004103,
bqc=0.1333,bcr=1/15,k1=0.01,k2=0.0235,λw=1,
δ=3.82,bic=0.626,
T1=25,T2=60,σ1=0.08,σ2=0.0094,
σ3=0.082,
σ4=0.078,σ5=0.084,
σ6=0.079;σ7=0.12.

Numerical solution of Covid-19 model for Case 3

In Case 3, assuming a given country within which the spread displays three processes, including classical behaviors, a passage from stretched exponential to power law behavior and finally stochastic behaviors. In this case, if we consider T as the last time of the spread, this is to say, the last day where a new infection occur, then, for the first period of time ranging from 0 to T1, the mathematical model will be constructed with classical differential operator, the second phrase, the model will be with the Atangana–Baleanu fractional differential operator and finally stochastic approach will be used at the last phase. The mathematical model explaining this dynamic is then presented below.

dSdt=Λbt+bqsQbsq+λSdEdt=btβ+beq+λEdIdt=βEδ+λ+bicIdQdt=bsqS+beqEbqs+bqc+λQdCdt=bqcQ+bicIδ+bcr+λCdRdt=bcrCλRdWdt=k1E+k2IλwW if 0tT1
dS=Λbt+bqsQbsq+λSdt+σ1SdB1tdE=btβ+beq+λEdt+σ2EdB2tdI=βEδ+λ+bicIdt+σ3IdB3tdQ=bsqS+beqEbqs+bqc+λQdt+σ4QdB4tdC=bqcQ+bicIδ+bcr+λCdt+σ5CdB5tdR=bcrCλRdt+σ6RdB6tdW=k1E+k2IλwWdt+σ7WdB7t if T1tT2
T2ABCDtαS=Λbt+bqsQbsq+λST2ABCDtαE=btβ+beq+λET2ABCDtαI=βEδ+λ+bicIT2ABCDtαQ=bsqS+beqEbqs+bqc+λQT2ABCDtαC=bqcQ+bicIδ+bcr+λCT2ABCDtαR=bcrCλRT2ABCDtαW=k1E+k2IλwW if T2tT.

In Fig. 22, Fig. 23, Fig. 24, Fig. 25, Fig. 26, Fig. 27, Fig. 28, the numerical simulations of model with piecewise derivative are depicted with

S0=10000,E0=1,I0=0,Q0=0,
C0=1,R0=1,W0=1, (54)
ST1=2022×105,ST2=1654×106,
ET1=1531,ET2=21840,
IT1=0.0585,IT2=0.4067,QT1=14890,QT2=334200,
CT1=505.1,CT2=2533,RT1=518,RT2=2910, (55)
WT1=335.3,WT2=4188

and the parameters

Λ=10000000,N=10000,αE=0.00003366,
αI=0.000006396,αW=0.00001886, (56)
bqs=0.008667,bsq=0.000015,κ=0.0066,λ=0.0182,β=0.00015,
beq=0.000004103,bqc=0.1333,bcr=1/15,k1=0.011,k2=0.0235,
λw=1,δ=3.82,bic=0.00626,T1=25,T2=60,σ1=0.08,σ2=0.0094,
σ3=0.082,σ4=0.078,σ5=0.084,σ6=0.079;σ7=0.12.

Comparison between piecewise model and real data for some countries

Comparison between a piecewise model and real data in Turkey

In this subsection, we compare modified model by using model that we introduced in the previous chapters with daily number of cases between March 11 and April 20, 2021 in Turkey [24]. Since it will not be easy to predict such long time interval data, to achieve greater compatibility between model that we will suggest and data, we will write our model in more pieces. In other words, although we presented our model in 3 pieces in the previous chapters, of course, we should know that we can write the model in more pieces in order to capture more reality in modeling daily problems. Thus, it will be inevitable for us to achieve our goal. But since this situation brings much more complexity with it, that is why let us first present some notations to avoid this complexity. We will use the notation Xi,i=1,2,,7 such that

X1=S,X2=E,X3=I,X4=Q,X5=C,X6=R,X7=W (57)

and

f1t,X1=Λbt+bqsQbsq+λS
f2t,X2=btβ+beq+λE
f3t,X3=βEδ+λ+bicI
f4t,X4=bsqS+beqEbqs+bqc+λQ
f5t,X5=bqcQ+bicIδ+bcr+λC
f6t,X6=bcrCλR
f7t,X7=k1E+k2IλwW.

To do comparison, considering above notations, we construct the following model piecewisely

dXitdt=fit,Xi, if 0tT1Xi0=Xi,0,i=1,2,,7dXit=ft,Xidt+σiXidBit , if T1tT2XiT1=Xi,1,i=1,2,,7dXidt=fit,Xi, if T2tT3XiT2=Xi,2,dXit=ft,Xidt+σjXidBjt , if T3tT4XiT3=Xi,3,j=8,9,,14dXit=ft,Xidt+σjXidBjt , if T4tT5XiT4=Xi,4,j=8,9,,140CFDtαXit=ft,Xi+σkXiBkt , if T5tTXiT5=Xi,5,k=15,16,,21. (58)

We shall present the parameters and initial conditions that we used for comparison in Turkey. Initial conditions are considered as

X10=83000000,X20=1200,X30=1,X40=1,X50=1,
X60=1,X70=1, (59)
X1T1=134×108,X1T2=3312×108,X1T3=2612×108,
X1T4=1502×109,
X1T5=788×108,X2T1=32180,X2T2=337600,
X2T3=818800,
X2T4=333600,X2T5=191000,X3T1=95,
X3T2=2167,X3T3=1300,
X3T4=1900,X3T5=9174,X4T1=1706×105,
X4T2=4565×106,
X4T3=3619×107,X4T4=217×107,
X4T5=1113×106,X5T1=4168000,
X5T2=1623×105,X5T3=9611×105,X5T4=6008×104,
X5T5=2976×104,
X6T1=4899×103,X6T2=5018×105,X6T3=1019×107,
X6T4=8747×105,
X6T5=2624×105,X7T1=5140,X7T2=155400,
X7T3=1722×103,
X7T4=53510,X7T5=119200

and the parameters are

Λ=84000000,N=83000000,αE=0.3366,αI=0.6396,
αW=0.1886,bqs=0.8667, (60)
bsq=0.015,κ=1.66,λ=0.0182,β=0.014,beq=0.34103,
δ=4.82,bic=0.00626,
bqc=0.1333,bcr=1/5,k1=0.01,k2=0.0235,λw=0.011,
T1=15,T2=60,T3=258,
T4=285,T5=382,σ1=σ8=σ15=0.008,σ17=0.05,
σ2=σ9=σ16=0.0094,
σ3=0.2,σ10=0.07,σ4=σ11=σ18=0.0078,σ5=σ12=σ19=0.0084,
σ6=σ13=σ20=0.0079;σ7=σ14=σ21=0.0012.

The simulations for comparison are performed using above initial data and parameters in Fig. 29, Fig. 30. We shall note that, the theoretical parameters used here are those that matched with experimental data. The initial conditions are chosen from Turkish population and initial numbers of infected individuals.

Fig. 29.

Fig. 29

Comparison between piecewise model and real data in Turkey for α=0.98.

Fig. 30.

Fig. 30

Comparison between piecewise model and real data in Turkey for α=1.

Comparison between piecewise model and real data in Czechia

In this subsection, we compare the daily number of cases between 2 March and 20 April 2021 in Czech Republic with model that will be presented here to analyze the concept we have introduced and to display different processes  [24]. Thus, we present the following model which composed of 7 pieces

dXitdt=fit,Xi, if 0tT1Xi0=Xi,0,i=1,2,,7dXit=ft,Xidt+σiXidBit , if T1tT2XiT1=Xi,1,i=1,2,,7dXit=ft,Xidt+σjXidBjt, if T2tT3XiT2=Xi,2,j=8,9,,140CFDtαXit=ft,Xi+σkXiBkt , if T3tT4XiT3=Xi,3,k=15,16,,21 (61)
dXit=ft,Xidt+σlXidBlt , if T4tT5XiT4=Xi,4,l=21,22,,28dXit=ft,Xidt+σmXidBmt , if T5tT6XiT5=Xi,5,m=29,30,,35dXit=ft,Xidt+σnXidBnt , if T6tTXiT6=Xi,6,n=36,37,,42. (62)

The parameters and initial conditions that we used for comparison in Czechia are given as

X10=10600000,X20=2000,X30=1,X40=1,X50=1,
X60=1,X70=1, (63)
X1T1=5614×106,X1T2=5384×108,X1T3=4087×107,
X1T4=5244×108,
X1T5=4187×107,X1T6=6752×107,X2T1=57300,
X2T2=1682000,
X2T3=37220,X2T4=1761000,X2T5=42350,
X2T6=1726000,X3T1=321.4,
X3T2=7230,X3T3=6920,X3T4=8449,
X3T5=7221,X3T6=8995,
X4T1=827×105,X4T2=7956×106,
X4T3=5821×105,X4T4=217×107,
X4T5=8856×106,X4T6=1116×107,
X5T1=4422000,X5T2=2134×105,
X5T3=1851×104,X5T4=2597×105,
X5T5=2757×104,X5T6=2687×105,
X6T1=2324×104,X6T2=1197×106,
X6T3=5895×105,X6T4=192×106,
X6T5=8069×105,X6T6=2571×106,
X7T1=663200,X7T2=3443000,
X7T3=881600,X7T4=4649000,X7T5=1239000,
X7T6=5843000

and

Λ=10600000,N=10600000,αE=0.3366,αI=0.6396,
αW=0.1886,bqs=0.8667, (64)
bsq=0.015,κ=1.66,λ=0.0182,β=0.027,
beq=0.34103,δ=4.82,bic=0.00626,
bqc=0.1333,bcr=1/5,k1=0.01,k2=0.0235,
λw=0.011,T1=205,T2=245,T3=280,
T4=315,T5=349,T6=385,σ1=σ8=σ15=σ22=σ29=σ36=0.008,
σ2=σ9=σ16=σ23=σ30=σ37=0.0094,σ3=σ17=σ31=0.25,σ10=σ24=σ38=0.15,
σ4=σ11=σ18=σ25=σ32=σ39=0.0078,σ5=σ12=σ19=σ26=σ33=σ40=0.0084,
σ6=σ13=σ20=σ27=σ34=σ41=0.0079;σ7=σ14=σ21=σ28=σ35=σ42=0.0012.

The simulations for comparison are presented using above initial data and parameters in Fig. 31, Fig. 32. The theoretical parameters used here are those that matched with experimental data. The initial conditions are chosen from Czechia population and initial numbers of infected individuals.

Fig. 31.

Fig. 31

Comparison between piecewise model and real data in Czechia for α=0.985.

Fig. 32.

Fig. 32

Comparison between piecewise model and real data in Czechia for α=1.

Comparison between piecewise model and real data in Spain

In this subsection, we present a comparison between the daily number of cases on 23 February and 20 April 2021 in Spain and the model that is divided into 9 pieces [24]. To do comparison, considering above notations, we consider the following model

dXitdt=fit,Xi, if 0tT1Xi0=Xi,0,i=1,2,,7dXit=ft,Xidt+σiXidBit , if T1tT2XiT1=Xi,1,i=1,2,,7dXitdt=fit,Xi, if T2tT3XiT2=Xi,2,dXit=ft,Xidt+σjXidBjt , if T3tT4XiT3=Xi,3,j=8,9,,14dXit=ft,Xidt+σkXidBkt , if T4tT5XiT4=Xi,4,k=15,16,,21 (65)
dXit=ft,Xidt+σlXidBlt , if T5tT6XiT5=Xi,4,l=22,23,,280CFDtαXit=ft,Xi+σmXiBmt , if T6tT7XiT6=Xi,5,m=29,30,,35.dXit=ft,Xidt+σnXidBnt , if T7tT8XiT7=Xi,4,n=36,37,,42dXit=ft,Xidt+σpXidBpt , if T8tTXiT7=Xi,4,p=43,44,,49. (66)

The parameters and initial conditions are as follows

X10=10600000,X20=2000,X30=1,X40=1,
X50=1,X60=1,X70=1, (67)
X1T1=6169×106,X1T2=2218×108,X1T3=1176×109,
X1T4=3157×109,
X1T5=1158×109,X1T6=1616×109,X1T7=1234×109,
X1T8=2835×1010,
X2T1=81470,X2T2=346400,X2T3=789600,
X2T4=1693000,X2T5=185600,
X2T6=8615000,X2T7=183700,X2T8=8801×103,
X3T1=94.74,X3T2=2483,
X3T3=802.8,X3T4=10460,X3T5=15640,
X3T6=30210,X3T7=15350,
X3T8=40400,X4T1=8518×104,X4T2=276×107,
X4T3=1749×107,
X4T4=5072×107,X4T5=1704×107,X4T6=2097×108,
X4T7=1534×107,
X4T8=4639×108,X5T1=2223000,X5T2=7358×104,
X5T3=4652×105,
X5T4=119×107,X5T5=3766×105,X5T6=6673×106,
X5T7=5703×105,
X5T8=1222×107,X6T1=2324×104,X6T2=3017×105,
X6T3=3406×106,
X6T4=1092×107,X6T5=1215×107X6T6=332×108,
X6T7=1592×107,
X6T8=8128×107,X7T1=4752,X7T2=155600,
X7T3=1111×103,X7T4=321×104,
X7T5=1975000,X7T6=13830000,
X7T7=3502×103,X7T8=3013×104,

and

Λ=48000000,N=47000000,αE=0.3366,αI=0.6396,
αW=0.1886,bqs=0.8667, (68)
bsq=0.015,κ=1.66,λ=0.0182,β=0.014,beq=0.34103,
δ=4.82,bic=0.00626,
bqc=0.1333,bcr=1/5,k1=0.01,k2=0.0235,λw=0.011,
T1=15,T2=60,T3=144,
T4=205,T5=220,T6=261,T7=295,T8=350,σ1=σ8=σ15=σ22=σ29=σ36=0.008,
σ2=σ9=σ16=σ23=σ30=σ37=σ44=0.0094,
σ3=0.21,σ24=0.2,σ38=σ45=0.15
σ10=σ17=σ31=0.25,σ4=σ11=σ18=σ25=σ32=σ39=σ46=0.0078,
σ5=σ12=σ19=σ26=σ33=σ40=σ47=0.0084,
σ6=σ13=σ20=σ27=σ34=σ41=σ48=0.0079,
σ7=σ14=σ21=σ28=σ35=σ42=σ49=0.0012.

The simulations for comparison are provided using above initial data and parameters in Fig. 33, Fig. 34. The theoretical parameters used here are those that matched with experimental data. The initial conditions are chosen from Spain population and initial numbers of infected individuals.

Fig. 33.

Fig. 33

Comparison between piecewise model and real data in Spain for α=0.99.

Fig. 34.

Fig. 34

Comparison between piecewise model and real data in Spain for α=1.

Conclusion

Nature can be better understood or even predicted if the limitations of existing theories, approaches, methods are questioned, revised and updated. This is also the Case in epidemiological modeling, for many decades several theories have not been revisited but are still used even to analyze complex problems that cannot be really understood using existing theories. For example, how can we predict waves for a given infectious disease using existing methods? Although significant results have been suggested and some highly informative, however, when looking at the spread of Covid-19, especially data from some countries, one will quickly realize that some of them exhibit crossover behaviors, for example a passage from patterns with deterministic features to stochastic. We have attempted to open a new window of modeling such problems, by using the concept of piecewise modeling. We present some illustrative examples. The agreement of the piecewise models and experimental data let no doubt that this approach will help mankind to better predict crossover behaviors appearing in nature.

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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