For more information on this topic, CDC recommends the following link: https://www.cdc.gov/drugoverdose/index.html
Footnotes
Deaths per 100,000 standard population. Age-adjusted drug overdose death rates were calculated using the direct method and the 2000 U.S. Census Bureau standard population. In 2021, the age-adjusted drug overdose death rate was 32.4 per 100,000 standard population.
Drug overdose deaths were identified using International Classification of Diseases, Tenth Revision underlying cause-of-death codes X40–X44, X60–X64, X85, and Y10–Y14.