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. 1991 Oct;155(4):365–369.

Mechanisms and consequences of leukocyte-endothelial interaction.

J M Harlan 1, N B Vedder 1, R K Winn 1, C L Rice 1
PMCID: PMC1003014  PMID: 1685284

Abstract

Leukocyte adhesion to endothelium is a critical event in host defense against microorganisms and in the repair of tissue damage. Under some circumstances, however, altered leukocyte-endothelial interactions may contribute to the pathogenesis of inflammatory and immune diseases. In a number of experimental models, the inhibition of leukocyte adherence to endothelium substantially reduces vascular and tissue injury. Antiadhesion therapy may represent a novel approach to the treatment of a wide spectrum of clinical disorders.

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Selected References

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