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. 1987 Oct;46(10):746–749. doi: 10.1136/ard.46.10.746

Antibodies to intermediate filaments in polymyalgia rheumatica and giant cell arteritis: a sequential study.

B Dasgupta 1, O Duke 1, V Kyle 1, D G Macfarlane 1, B L Hazleman 1, G S Panayi 1
PMCID: PMC1003381  PMID: 2446569

Abstract

Serum specimens from 35 patients with polymyalgia rheumatica and giant cell arteritis (PMR/GCA) were obtained sequentially at variable time intervals up to a year from onset of disease. These were tested for antibodies to intermediate filaments by indirect immunofluorescence using HEp2 cells as substrate. Twenty four of 35 (68%) patients' sera at onset of disease were positive at an anti-intermediate filament antibody (AIFA) titre of greater than 1/40 compared with three outs of 19 (15%) control sera. AIFA were predominantly of IgM class, and there was no significant change in AIFA titres on follow up despite clinical remission of disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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