Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1987 Oct;46(10):768–772. doi: 10.1136/ard.46.10.768

Clinical studies of renal disease in Sjögren's syndrome.

S Shiozawa 1, K Shiozawa 1, S Shimizu 1, M Nakada 1, T Isobe 1, T Fujita 1
PMCID: PMC1003385  PMID: 3689002

Abstract

When 17 patients with Sjögren's syndrome, without apparent clinical manifestations of renal disease, were examined renal function studies frequently indicated abnormalities in their renal phosphate handling. The percentage tubular reabsorption of phosphate (%TRP) was decreased in six (35.3%), and maximal tubular reabsorption rate for phosphate (TmPO4/GFR) was low in eight (47.1%). In contrast, indices of renal calcium handling and serum parathyroid hormone levels were normal, suggesting that the abnormalities of phosphate metabolism were due not to extrinsic, but rather to intrinsic disease processes occurring in the kidney in Sjögren's syndrome. When the patients were divided into two groups according to the presence or absence of a renal tubular acidification defect (RTAD), patients with RTAD were younger (p less than 0.005), had longer disease duration (p less than 0.01), lower creatinine clearance (p less than 0.05), and higher incidence of low %TRP (p less than 0.05). Thus the patients with lower creatinine clearance generally had disease of longer duration at diagnosis and tended also to have defects in concentrating and acidifying the urine.

Full text

PDF
768

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alarcon-Segovia D., Ibanez G., Hernandez-Ortiz, Cetina J. A., Gonzalel-Jimenez Y., Diaz-Jouanen E. Salivary gland involvement in diseases associated with Sjögren's syndrome. 1. Radionuclide & roentgenorgraphic studies. J Rheumatol. 1974 Jun;1(2):159–165. [PubMed] [Google Scholar]
  2. BLOCH K. J., BUCHANAN W. W., WOHL M. J., BUNIM J. J. SJOEGREN'S SYNDROME. A CLINICAL, PATHOLOGICAL, AND SEROLOGICAL STUDY OF SIXTY-TWO CASES. Medicine (Baltimore) 1965 May;44:187–231. [PubMed] [Google Scholar]
  3. Chisholm D. M., Mason D. K. Labial salivary gland biopsy in Sjögren's disease. J Clin Pathol. 1968 Sep;21(5):656–660. doi: 10.1136/jcp.21.5.656. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Daniels T. E. Labial salivary gland biopsy in Sjögren's syndrome. Assessment as a diagnostic criterion in 362 suspected cases. Arthritis Rheum. 1984 Feb;27(2):147–156. doi: 10.1002/art.1780270205. [DOI] [PubMed] [Google Scholar]
  5. GORDON M. E., SHANBROM E. The systemic manifestations of Sjögren's syndrome: report of glandular function with histologic, bacterial and viral studies. Ann Intern Med. 1958 Jun;48(6):1342–1359. doi: 10.7326/0003-4819-48-6-1342. [DOI] [PubMed] [Google Scholar]
  6. Gonzalez L., Mackenzie A. H., Tarar R. A. Parotid sialography in Sjögren's syndrome. Radiology. 1970 Oct;97(1):91–93. doi: 10.1148/97.1.91. [DOI] [PubMed] [Google Scholar]
  7. KAHN M., MERRITT A. D., WOHL M. J., ORLOFF J. Renal concentrating defect in Sjogren's syndrome. Ann Intern Med. 1962 Jun;56:883–895. doi: 10.7326/0003-4819-56-6-883. [DOI] [PubMed] [Google Scholar]
  8. Morris R. C., Jr, Fudenberg H. H. Impaired renal acidification in patients with hypergammaglobulinemia. Medicine (Baltimore) 1967 Jan;46(1):57–69. doi: 10.1097/00005792-196701000-00003. [DOI] [PubMed] [Google Scholar]
  9. Pasternack A., Linder E. Renal tubular acidosis: an immunopathological study on four patients. Clin Exp Immunol. 1970 Jul;7(1):115–123. [PMC free article] [PubMed] [Google Scholar]
  10. Payne R. B., Little A. J., Williams R. B., Milner J. R. Interpretation of serum calcium in patients with abnormal serum proteins. Br Med J. 1973 Dec 15;4(5893):643–646. doi: 10.1136/bmj.4.5893.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. SHEARN M. A., TU W. H. NEPHROGENIC DIABETIC INSIPIDUS AND OTHER DEFECTS OF RENAL TUBULAR FUNCTION IN SJOERGREN'S SYNDROME. Am J Med. 1965 Aug;39:312–318. doi: 10.1016/0002-9343(65)90057-4. [DOI] [PubMed] [Google Scholar]
  12. Shearn M. A., Tu W. H. Latent renal tubular acidosis in Sjøgren's syndrome. Ann Rheum Dis. 1968 Jan;27(1):27–32. doi: 10.1136/ard.27.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Shimizu S., Shiozawa S., Shiozawa K., Imura S., Fujita T. Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis. Arthritis Rheum. 1985 Jan;28(1):25–31. doi: 10.1002/art.1780280105. [DOI] [PubMed] [Google Scholar]
  14. Shioji R., Furuyama T., Onodera S., Saito H., Ito H., Sasaki Y. Sjögren's syndrome and renal tubular acidosis. Am J Med. 1970 Apr;48(4):456–463. doi: 10.1016/0002-9343(70)90045-8. [DOI] [PubMed] [Google Scholar]
  15. Strand V., Talal N. Advances in the diagnosis and concept of Sjögren's syndrome (autoimmune exocrinopathy). Bull Rheum Dis. 1979;30(9):1046–1052. [PubMed] [Google Scholar]
  16. Talal N., Zisman E., Schur P. H. Renal tubular acidosis, glomerulonephritis and immunologic factors in Sjögren's syndrome. Arthritis Rheum. 1968 Dec;11(6):774–786. doi: 10.1002/art.1780110607. [DOI] [PubMed] [Google Scholar]
  17. Tu W. H., Shearn M. A., Lee J. C., Hopper J., Jr Interstitial nephritis in Sjögren's syndrome. Ann Intern Med. 1968 Dec;69(6):1163–1170. doi: 10.7326/0003-4819-69-6-1163. [DOI] [PubMed] [Google Scholar]
  18. Walton R. J., Bijvoet O. L. Nomogram for derivation of renal threshold phosphate concentration. Lancet. 1975 Aug 16;2(7929):309–310. doi: 10.1016/s0140-6736(75)92736-1. [DOI] [PubMed] [Google Scholar]
  19. Whaley K., Webb J., McAvoy B. A., Hughes G. R., Lee P., MacSween R. N., Buchanan W. W. Sjogren's syndrome. 2. Clinical associations and immunological phenomena. Q J Med. 1973 Jul;42(167):513–548. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES