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. 1987 Oct;46(10):777–779. doi: 10.1136/ard.46.10.777

Effect of oestrogen treatment on clinical and laboratory manifestations of rheumatoid arthritis.

J W Bijlsma 1, O Huber-Bruning 1, J H Thijssen 1
PMCID: PMC1003387  PMID: 3318724

Abstract

The effect of administration of 12.5 micrograms ethinyloestradiol to 10 female patients with active rheumatoid arthritis was investigated in a prospective double blind crossover study. Some improvement during oestrogen treatment was found in 30 m walking time, haemoglobin concentration, and thrombocytosis. Erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) deteriorated in both periods, but less in the oestrogen period. Grip strength improved during both periods. The number of swollen joints decreased, whereas the joint tenderness score increased during the oestrogen period.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berczi I., Nagy E., Asa S. L., Kovacs K. The influence of pituitary hormones on adjuvant arthritis. Arthritis Rheum. 1984 Jun;27(6):682–688. doi: 10.1002/art.1780270612. [DOI] [PubMed] [Google Scholar]
  2. Fernandes G., Talal N. SLE: hormones and diet. Clin Exp Rheumatol. 1986 Apr-Jun;4(2):183–185. [PubMed] [Google Scholar]
  3. GILBERT M., ROTSTEIN J., CUNNINGHAM C., ESTRIN I., DAVIDSON A., PINCUS G. NORETHYNODREL WITH MESTRANOL IN TREATMENT OF RHEUMATOID ARTHRITIS. JAMA. 1964 Oct 19;190:235–235. doi: 10.1001/jama.1964.03070160059013. [DOI] [PubMed] [Google Scholar]
  4. Grossman C. J. Regulation of the immune system by sex steroids. Endocr Rev. 1984 Summer;5(3):435–455. doi: 10.1210/edrv-5-3-435. [DOI] [PubMed] [Google Scholar]
  5. Jungers P., Kuttenn F., Liote F., Pelissier C., Athea N., Laurent M. C., Viriot J., Dougados M., Bach J. F. Hormonal modulation in systemic lupus erythematosus. Preliminary clinical and hormonal results with cyproterone acetate. Arthritis Rheum. 1985 Nov;28(11):1243–1250. doi: 10.1002/art.1780281108. [DOI] [PubMed] [Google Scholar]
  6. Lahita R. G. Sex steroids and the rheumatic diseases. Arthritis Rheum. 1985 Feb;28(2):121–126. doi: 10.1002/art.1780280202. [DOI] [PubMed] [Google Scholar]
  7. Latman N. S. Relation of menstrual cycle phase to symptoms of rheumatoid arthritis. Am J Med. 1983 Jun;74(6):957–960. doi: 10.1016/0002-9343(83)90789-1. [DOI] [PubMed] [Google Scholar]
  8. Mason R. M., Lineham J. D., Phillipson M. A., Black C. M. Selective inhibition of proteoglycan and hyaluronate synthesis in chondrocyte cultures by cyclofenil diphenol, a non-steroidal weak oestrogen. Biochem J. 1984 Oct 15;223(2):401–412. doi: 10.1042/bj2230401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ostensen M., Aune B., Husby G. Effect of pregnancy and hormonal changes on the activity of rheumatoid arthritis. Scand J Rheumatol. 1983;12(2):69–72. doi: 10.3109/03009748309102886. [DOI] [PubMed] [Google Scholar]
  10. Ritchie D. M., Boyle J. A., McInnes J. M., Jasani M. K., Dalakos T. G., Grieveson P., Buchanan W. W. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968 Jul;37(147):393–406. [PubMed] [Google Scholar]
  11. Vandenbroucke J. P., Witteman J. C., Valkenburg H. A., Boersma J. W., Cats A., Festen J. J., Hartman A. P., Huber-Bruning O., Rasker J. J., Weber J. Noncontraceptive hormones and rheumatoid arthritis in perimenopausal and postmenopausal women. JAMA. 1986 Mar 14;255(10):1299–1303. [PubMed] [Google Scholar]
  12. Weusten J. J., Blankenstein M. A., Gmelig-Meyling F. H., Schuurman H. J., Kater L., Thijssen J. H. Presence of oestrogen receptors in human blood mononuclear cells and thymocytes. Acta Endocrinol (Copenh) 1986 Jul;112(3):409–414. doi: 10.1530/acta.0.1120409. [DOI] [PubMed] [Google Scholar]
  13. van Kammen E., Thijssen J. H., Rademaker B., Schwarz F. The influence of hormonal contraceptives on sex hormone binding globulin (SHBG) capacity. Contraception. 1975 Jan;11(1):53–59. doi: 10.1016/0010-7824(75)90050-5. [DOI] [PubMed] [Google Scholar]

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