Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1987 Dec;46(12):883–888. doi: 10.1136/ard.46.12.883

Antibody producing capacity to the bacteriophage phi X174 in yersinia arthritis.

R Bucknall 1, M Leirisalo-Repo 1, O Laitinen 1, J V Jones 1
PMCID: PMC1003417  PMID: 2962540

Abstract

Antibody production in response to the primary immunogen bacteriophage phi X174 was investigated in 14 patients with previous yersinia arthritis (YA) and in 15 controls. HLA-B27 occurred in 10 patients with YA and in three controls. After primary and secondary immunisation the antibody responses were essentially similar both in patients with YA and controls. Consequently our results suggest that antibody response to a foreign antigen does not differ between patients with YA and a normal control population. In addition, there was no difference in peak antibody responses between individuals with HLA-B27 and those without HLA-B27.

Full text

PDF
883

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aho K., Ahvonen P., Lassus A., Sievers K., Tiilikainen A. HL-A 27 in reactive arthritis. A study of Yersinia arthritis and Reiter's disease. Arthritis Rheum. 1974 Sep-Oct;17(5):521–526. doi: 10.1002/art.1780170505. [DOI] [PubMed] [Google Scholar]
  2. Baier R., Puppel H., Hahn E. Erkrankungen durch Yersinia enterocolitica. Bakteriologisch-serologische, epidemiologische und immunologische Befunde bei 51 Erkrankungen. Dtsch Med Wochenschr. 1979 Feb 23;104(8):281–285. doi: 10.1055/s-0028-1103894. [DOI] [PubMed] [Google Scholar]
  3. Christiansen F. T., Hawkins B. R., Dawkins R. L. Immune function in ankylosing spondylitics and their relatives: influence of disease and HLA B27. Clin Exp Immunol. 1978 Aug;33(2):270–275. [PMC free article] [PubMed] [Google Scholar]
  4. Fan P. T., Clements P. J., Yu D. T., Opelz G., Bluestone R. Lymphocyte abnormalities in ankylosing spondylitis. Ann Rheum Dis. 1977 Oct;36(5):471–473. doi: 10.1136/ard.36.5.471. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ford D. K. Yersinia-induced arthritis and Reiter's syndrome. Ann Rheum Dis. 1979;38 (Suppl 1):suppl–128. doi: 10.1136/ard.38.suppl_1.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Froebel K., Sturrock R. D., Reynolds P., Grennan A., Roxburgh A., MacSween R. N. In-vitro reactions of lymphocytes in rheumatoid arthritis and other rheumatic diseases. Ann Rheum Dis. 1979 Dec;38(6):535–543. doi: 10.1136/ard.38.6.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Granfors K., Viljanen M., Tiilikainen A., Toivanen A. Persistence of IgM, IgG, and IgA antibodies to Yersinia in yersinia arthritis. J Infect Dis. 1980 Apr;141(4):424–429. doi: 10.1093/infdis/141.4.424. [DOI] [PubMed] [Google Scholar]
  8. Gripenberg M., Miettinen A., Kurki P., Linder E. Humoral immune stimulation and antiepithelial antibodies in Yersinia infection. Arthritis Rheum. 1978 Nov-Dec;21(8):904–908. doi: 10.1002/art.1780210806. [DOI] [PubMed] [Google Scholar]
  9. Laitinen O., Leirisalo M., Skylv G. Relation between HLA-B27 and clinical features in patients with yersinia arthritis. Arthritis Rheum. 1977 Jun;20(5):1121–1124. doi: 10.1002/art.1780200512. [DOI] [PubMed] [Google Scholar]
  10. Leirisalo M., Laitinen O., Tiilikainen A. HLA phenotypes in patients with rheumatic fever, rheumatic heart disease, and Yersinia arthritis. J Rheumatol Suppl. 1977;3:78–83. [PubMed] [Google Scholar]
  11. Leirisalo M., Repo H., Tiilikainen A., Kosunen T. U., Laitinen O. Chemotaxis in yersinia arthritis. HLA-B27 positive neutrophils show high stimulated motility in vitro. Arthritis Rheum. 1980 Sep;23(9):1036–1044. doi: 10.1002/art.1780230911. [DOI] [PubMed] [Google Scholar]
  12. Liyanage S. P., Currey H. L., Vernon-Roberts B. Influence of tubercle aggregate size on severity of adjuvant arthritis in the rat. Ann Rheum Dis. 1975 Feb;34(1):49–53. doi: 10.1136/ard.34.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mattila P. S., Valtonen V., Tuori M. R., Mäkelä O. Antibody responses in arthritic and uncomplicated Yersinia enterocolitica infections. J Clin Immunol. 1985 Nov;5(6):404–411. doi: 10.1007/BF00915338. [DOI] [PubMed] [Google Scholar]
  14. Nikbin B., Brewerton D. A., James D. C., Hobbs J. R. Diminished mixed lymphocyte reaction in ankylosing spondylitis, relatives, and normal individuals all with HL-A 27. Ann Rheum Dis. 1976 Feb;35(1):37–39. doi: 10.1136/ard.35.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Peacock D. B., Jones J. V., Gough M. The immune response to thetaX 174 in man. I. Primary and secondary antibody production in normal adults. Clin Exp Immunol. 1973 Apr;13(4):497–513. [PMC free article] [PubMed] [Google Scholar]
  16. Pirofsky B., Rosner E. R. DTT test: a new method to differentiate IgM and IgG erythrocyte antibodies. Vox Sang. 1974;27(5):480–488. doi: 10.1111/j.1423-0410.1974.tb02446.x. [DOI] [PubMed] [Google Scholar]
  17. Wee S. L., Daymond T. J. Diminished mixed lymphocyte response in ankylosing spondylitis. Tissue Antigens. 1978 May;11(5):409–417. doi: 10.1111/j.1399-0039.1978.tb01276.x. [DOI] [PubMed] [Google Scholar]
  18. Zilko P. J., Thevathasan M., Dawkins R. L. Immune function in ankylosing spondylitis: apparent relationship between streptococcal responses and HLA B27. J Rheumatol Suppl. 1977;3:49–53. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES