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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1987 Dec;46(12):898–901. doi: 10.1136/ard.46.12.898

Association of persisting IgA response with yersinia triggered reactive arthritis: a study on 104 patients.

A Toivanen 1, R Lahesmaa-Rantala 1, R Vuento 1, K Granfors 1
PMCID: PMC1003419  PMID: 3426298

Abstract

Twelve to 16 months after Yersinia enterocolitica O:3 enteritis 33 (85%) of the 39 patients who developed reactive arthritis as a postinfection complication had IgA class and 28 (72%) had IgG class anti-yersinia antibodies. In contrast, 7 (32%) of the 22 patients who did not develop arthritis were positive in the IgA test and 11 (50%) positive in the IgG test. The results were about the same when the material was divided into cases with diagnosis of yersiniosis verified by stool culture or by serology. These results confirm the value of enzyme linked immunosorbent assay (ELISA) in the diagnosis of yersiniosis, particularly in cases with postinfection complications when the stool isolations remain negative.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Diagnosis of human brucellosis with ELISA. Lancet. 1982 Sep 18;2(8299):668–668. [PubMed] [Google Scholar]
  2. Foberg U., Frydén A., Kihlström E., Persson K., Weiland O. Yersinia enterocolitica septicemia: clinical and microbiological aspects. Scand J Infect Dis. 1986;18(4):269–279. doi: 10.3109/00365548609032337. [DOI] [PubMed] [Google Scholar]
  3. Granfors K., Toivanen A. ELISA and RIA for serologic diagnosis of yersiniosis. Rev Infect Dis. 1984 May-Jun;6(3):421–424. doi: 10.1093/clinids/6.3.421-a. [DOI] [PubMed] [Google Scholar]
  4. Granfors K., Toivanen A. IgA-anti-yersinia antibodies in yersinia triggered reactive arthritis. Ann Rheum Dis. 1986 Jul;45(7):561–565. doi: 10.1136/ard.45.7.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Granfors K., Viljanen M. K., Toivanen A. Measurement of immunoglobulin M, immunoglobulin G, and immunoglobulin A antibodies against Yersinia enterocolitica by enzyme-linked immunosorbent assay: comparison of lipopolysaccharide and whole bacterium as antigen. J Clin Microbiol. 1981 Jul;14(1):6–14. doi: 10.1128/jcm.14.1.6-14.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Granfors K., Viljanen M., Tiilikainen A., Toivanen A. Persistence of IgM, IgG, and IgA antibodies to Yersinia in yersinia arthritis. J Infect Dis. 1980 Apr;141(4):424–429. doi: 10.1093/infdis/141.4.424. [DOI] [PubMed] [Google Scholar]
  7. Gripenberg M. Common serological features in rheumatoid arthritis and yersinia arthritis. Demonstration of rheumatoid factors and antibodies against ssDNA and Yersinia enterocolitica Lipopolysaccharide by ELISA. Scand J Rheumatol. 1981;10(2):85–91. doi: 10.3109/03009748109095278. [DOI] [PubMed] [Google Scholar]
  8. Kobayashi S., Ogasawara M., Maeda K., Yu D. T. Antibodies against Yersinia enterocolitica in patients with Reiter's syndrome. J Lab Clin Med. 1985 Mar;105(3):380–389. [PubMed] [Google Scholar]
  9. Lange S., Larsson P. What do serum antibodies to Yersinia enterocolitica indicate? Rev Infect Dis. 1984 Nov-Dec;6(6):880–881. doi: 10.1093/clinids/6.6.880. [DOI] [PubMed] [Google Scholar]
  10. Larsen J. H., Hartzen S. H., Parm M. The determination of specific IgA-antibodies to Yersinia enterocolitica and their role in enteric infections and their complications. Acta Pathol Microbiol Immunol Scand B. 1985 Oct;93(5):331–339. doi: 10.1111/j.1699-0463.1985.tb02897.x. [DOI] [PubMed] [Google Scholar]
  11. Mattila P. S., Valtonen V., Tuori M. R., Mäkelä O. Antibody responses in arthritic and uncomplicated Yersinia enterocolitica infections. J Clin Immunol. 1985 Nov;5(6):404–411. doi: 10.1007/BF00915338. [DOI] [PubMed] [Google Scholar]
  12. Toivanen P., Toivanen A., Olkkonen L., Aantaa S. Is the incidence of Yersinia enterocolitica infection increasing? Acta Pathol Microbiol Scand B Microbiol Immunol. 1974 Apr;82(2):303–304. doi: 10.1111/j.1699-0463.1974.tb02330.x. [DOI] [PubMed] [Google Scholar]
  13. Trull A., Ebringer A., Panayi G., Ebringer R., James D. C. HLA-B27 and the immune response to enterobacterial antigens in ankylosing spondylitis. Clin Exp Immunol. 1984 Jan;55(1):74–80. [PMC free article] [PubMed] [Google Scholar]
  14. van Bohemen C. G., Lionarons R. J., van Bodegom P., Dinant H. J., Landheer J. E., Nabbe A. J., Grumet F. C., Zanen H. C. Susceptibility and HLA-B27 in post-dysenteric arthropathies. Immunology. 1985 Oct;56(2):377–379. [PMC free article] [PubMed] [Google Scholar]

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