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. 1988 Mar;47(3):183–189. doi: 10.1136/ard.47.3.183

Value of joint scintigraphy in the prediction of erosiveness in early rheumatoid arthritis.

T T Möttönen 1, P Hannonen 1, J Toivanen 1, A Rekonen 1, M Oka 1
PMCID: PMC1003481  PMID: 3355257

Abstract

The value of scintigraphy in predicting development of new erosions in small peripheral joints was studied by visual evaluation of scintigrams and by three computerised methods. In 13 patients with newly diagnosed rheumatoid arthritis a total of 387 joints were examined clinically, scintigraphically, and radiographically. The follow up period was 24 months. Four eroded joints in three patients were found at the onset. Of the joints which were to become eroded, 46/47 were scintigraphically active at all the check ups. Erosions were detected earlier in foot joints than in finger joints. New erosions were especially prone to appear in joints with persisting and high scintigraphic activity. On the contrary, inactive joints by repeated scanning never eroded. Scintigraphic and clinical activity and radiographic erosiveness correlated significantly with each other. The sensitivity and specificity of visual scintigraphic assessment and the relative pixel activity method proved to be superior to the region of interest methods and clinical evaluation for prediction of erosiveness.

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Selected References

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  1. Amos R. S., Constable T. J., Crockson R. A., Crockson A. P., McConkey B. Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes. Br Med J. 1977 Jan 22;1(6055):195–197. doi: 10.1136/bmj.1.6055.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brook A., Corbett M. Radiographic changes in early rheumatoid disease. Ann Rheum Dis. 1977 Feb;36(1):71–73. doi: 10.1136/ard.36.1.71. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association. Ann Rheum Dis. 1959 Mar;18(1):49–53. [PMC free article] [PubMed] [Google Scholar]
  4. DUTHIE J. J., BROWN P. E., KNOX J. D., THOMPSON M. Course and prognosis in rheumatoid arthritis. Ann Rheum Dis. 1957 Dec;16(4):411–424. doi: 10.1136/ard.16.4.411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Desaulniers M., Fuks A., Hawkins D., Lacourciere Y., Rosenthall L. Radiotechnetium polyphosphate joint imaging. J Nucl Med. 1974 Jun;15(6):417–423. [PubMed] [Google Scholar]
  6. Dick W. C., Deodhar S. D., Provan C. J., Nuki G., Buchanan W. W. Isotope studies in normal and diseased knee joints: 99mTc uptake related to clinical assessment and to synovial perfusion measured by the 133Xe clearance technique. Clin Sci. 1971 Apr;40(4):327–336. doi: 10.1042/cs0400327. [DOI] [PubMed] [Google Scholar]
  7. Fleming A., Crown J. M., Corbett M. Prognostic value of early features in rheumatoid disease. Br Med J. 1976 May 22;1(6020):1243–1245. doi: 10.1136/bmj.1.6020.1243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hutton C. W., Higgs E. R., Jackson P. C., Watt I., Dieppe P. A. 99mTc HMDP bone scanning in generalised nodal osteoarthritis. II. The four hour bone scan image predicts radiographic change. Ann Rheum Dis. 1986 Aug;45(8):622–626. doi: 10.1136/ard.45.8.622. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Larsen A., Dale K., Eek M. Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diagn (Stockh) 1977 Jul;18(4):481–491. doi: 10.1177/028418517701800415. [DOI] [PubMed] [Google Scholar]
  10. Möttönen T., Hannonen P., Rekonen A., Oka M. Joint scintigraphy and erosions. Ann Rheum Dis. 1986 Nov;45(11):966–967. doi: 10.1136/ard.45.11.966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ochi T., Yonemasu K., Iwase R., Sasaki T., Tsuyama K., Ono K. Serum C1q levels as a prognostic guide to articular erosions in patients with rheumatoid arthritis. Arthritis Rheum. 1984 Aug;27(8):883–887. doi: 10.1002/art.1780270807. [DOI] [PubMed] [Google Scholar]
  12. Oh B. K., Macfarlane J. D., Goei The H. S., Pauwels E. K. Sequential joint scintigraphy in rheumatoid arthritis. Clin Rheumatol. 1983 Mar;2(1):45–51. doi: 10.1007/BF02032067. [DOI] [PubMed] [Google Scholar]
  13. Oka M., Möttönen T., Rekonen A. A comparison of 99mTc-MDP and 99mTc-pertechnetate by computerized quantitative joint scintigraphy. Scand J Rheumatol. 1983;12(1):46–48. doi: 10.3109/03009748309102004. [DOI] [PubMed] [Google Scholar]
  14. Pitt P., Berry H., Clarke M., Foley H., Barratt J., Parsons V. Metabolic activity of erosions in rheumatoid arthritis. Ann Rheum Dis. 1986 Mar;45(3):235–238. doi: 10.1136/ard.45.3.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Ritchie D. M., Boyle J. A., McInnes J. M., Jasani M. K., Dalakos T. G., Grieveson P., Buchanan W. W. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968 Jul;37(147):393–406. [PubMed] [Google Scholar]
  16. Teitsson I., Withrington R. H., Seifert M. H., Valdimarsson H. Prospective study of early rheumatoid arthritis. I. Prognostic value of IgA rheumatoid factor. Ann Rheum Dis. 1984 Oct;43(5):673–678. doi: 10.1136/ard.43.5.673. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wallace D. J., Brachman M., Klinenberg J. R. Joint scanning in rheumatoid arthritis: a literature review. Semin Arthritis Rheum. 1981 Aug;11(1):172–176. doi: 10.1016/0049-0172(81)90097-4. [DOI] [PubMed] [Google Scholar]
  18. Westedt M. L., Daha M. R., Baldwin W. M., 3rd, Stijnen T., Cats A. Serum immune complexes containing IgA appear to predict erosive arthritis in a longitudinal study in rheumatoid arthritis. Ann Rheum Dis. 1986 Oct;45(10):809–815. doi: 10.1136/ard.45.10.809. [DOI] [PMC free article] [PubMed] [Google Scholar]

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