Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1988 Apr;47(4):337–339. doi: 10.1136/ard.47.4.337

Sarcoidosis presenting as antinuclear antibody positive glomerulonephritis.

M C Soto-Aguilar 1, D W Boulware 1
PMCID: PMC1003517  PMID: 3259126

Abstract

A 43 year old woman who initially presented with the nephrotic syndrome, glomerulonephritis, and antinuclear antibodies (ANAs) was given the diagnosis of systemic lupus erythematosus (SLE). One year later the patient developed progressive subcutaneous nodules on her forearms, with histopathology of non-caseating granulomas. Further evaluation of the patient showed mediastinal lymphadenopathy and interstitial lung disease with numerous granulomas, establishing the diagnosis of sarcoidosis. The presence of autoimmune antibodies and glomerulonephritis has been reported in sarcoidosis, but this case is believed to be the first in which both glomerulonephritis and ANAs are present in a sarcoid patient.

Full text

PDF
337

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Goldszer R. C., Galvanek E. G., Lazarus J. M. Glomerulonephritis in a patient with sarcoidosis. Report of a case and review of the literature. Arch Pathol Lab Med. 1981 Sep;105(9):478–481. [PubMed] [Google Scholar]
  2. Lawrence H. J., Greenberg B. R. Autoimmune thrombocytopenia in sarcoidosis. Am J Med. 1985 Dec;79(6):761–764. doi: 10.1016/0002-9343(85)90528-5. [DOI] [PubMed] [Google Scholar]
  3. Muther R. S., McCarron D. A., Bennett W. M. Renal manifestations of sarcoidosis. Arch Intern Med. 1981 Apr;141(5):643–645. [PubMed] [Google Scholar]
  4. Needleman S. W., Silber R. A., Von Brecht J. H., Goeken J. A. Systemic lupus erythematosus complicated by disseminated sarcoidosis. Report of a case associated with circulating immune complexes. Am J Clin Pathol. 1982 Jul;78(1):105–107. doi: 10.1093/ajcp/78.1.105. [DOI] [PubMed] [Google Scholar]
  5. Olenchock S. A., Marx J. J., Jr, Mull J. C., Mentnech M. S., Spurgeon D. E., Gladish M. E., Elliott J. A., Pearson D. J., Price C. D., Major P. C. Immunology of clinically inactive sarcoidosis: serum factors. Ann Allergy. 1981 Jul;47(1):28–31. [PubMed] [Google Scholar]
  6. Oreskes I., Siltzbach L. E. Changes in rheumatoid factor activity during the course of sarcoidosis. Am J Med. 1968 Jan;44(1):60–67. doi: 10.1016/0002-9343(68)90237-4. [DOI] [PubMed] [Google Scholar]
  7. Taylor R. G., Fisher C., Hoffbrand B. I. Sarcoidosis and membranous glomerulonephritis: a significant association. Br Med J (Clin Res Ed) 1982 May 1;284(6325):1297–1298. doi: 10.1136/bmj.284.6325.1297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Veien N. K., Hardt F., Bendixen G., Genner J., Ringsted J., Wanstrup J., Wiik A., Christiansen E. Humoral and cellular immunity in sarcoidosis. Acta Med Scand. 1978;203(4):321–326. doi: 10.1111/j.0954-6820.1978.tb14881.x. [DOI] [PubMed] [Google Scholar]
  9. Wiesenhutter G. W., Sharma O. P. Is sarcoidosis an autoimmune disease?: Report of four cases and review of the literature. Semin Arthritis Rheum. 1979 Nov;9(2):124–144. doi: 10.1016/s0049-0172(79)80003-7. [DOI] [PubMed] [Google Scholar]
  10. de la Figuera von Wichmann M., Marquet Palomer R., Vilardell Tarrés M., Ribera Pascuet E., Villar Casares M. Autoinmunidad en una paciente con sarcoidosis. Med Clin (Barc) 1983 Sep 17;81(7):320–320. [PubMed] [Google Scholar]
  11. de la Figuera M., Sanjuas C., Vilardell M., Morera J., Marquet R., del Mar Villar M. Anticuerpos antinucleares en la sarcoidosis. Med Clin (Barc) 1983 Dec 10;81(19):878–879. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES