Abstract
Fifty two patients with psoriatic spondyloarthropathy were monitored prospectively over a mean of 57 months (range 30-107). A comprehensive protocol was used to assess clinical and radiological features of disease activity and severity. Serial radiographs showed a significant increase in the number of patients with syndesmophyte formation and sacroiliitis. In contrast, there was no significant increase in the number of patients with inflammatory neck pain or stiffness, back pain or stiffness, cervical spine limitation, or sacroiliac tenderness. Similarly, there were no significant changes in any of the direct or indirect measurements of thoracolumbar spine mobility. The presence of HLA-B27 did not appear to influence disease progression. These results suggest that although patients with psoriatic spondyloarthropathy have radiological progression of their disease, this remains clinically silent and does not compromise spinal mobility.
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- AVILA R., PUGH D. G., SLOCUMB C. H., WINKELMANN R. K. Psoriatic arthritis: a roentgenologic study. Radiology. 1960 Nov;75:691–702. doi: 10.1148/75.5.691. [DOI] [PubMed] [Google Scholar]
- Barraclough D., Russell A. S., Percy J. S. Psoriatic spondylitis: a clinical, radiological, and scintiscan survey. J Rheumatol. 1977 Autumn;4(3):282–287. [PubMed] [Google Scholar]
- Brewerton D. A., Hart F. D., Nicholls A., Caffrey M., James D. C., Sturrock R. D. Ankylosing spondylitis and HL-A 27. Lancet. 1973 Apr 28;1(7809):904–907. doi: 10.1016/s0140-6736(73)91360-3. [DOI] [PubMed] [Google Scholar]
- Bywaters E. G., Dixon A. S. Paravertebral ossification in psoriatic arthritis. Ann Rheum Dis. 1965 Jul;24(4):313–331. doi: 10.1136/ard.24.4.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carette S., Graham D., Little H., Rubenstein J., Rosen P. The natural disease course of ankylosing spondylitis. Arthritis Rheum. 1983 Feb;26(2):186–190. doi: 10.1002/art.1780260210. [DOI] [PubMed] [Google Scholar]
- Gladman D. D., Anhorn K. A., Schachter R. K., Mervart H. HLA antigens in psoriatic arthritis. J Rheumatol. 1986 Jun;13(3):586–592. [PubMed] [Google Scholar]
- Gladman D. D., Shuckett R., Russell M. L., Thorne J. C., Schachter R. K. Psoriatic arthritis (PSA)--an analysis of 220 patients. Q J Med. 1987 Feb;62(238):127–141. [PubMed] [Google Scholar]
- Jajić I. Radiological changes in the sacro-iliac joints and spine of patients with psoriatic arthritis and psoriasis. Ann Rheum Dis. 1968 Jan;27(1):1–6. doi: 10.1136/ard.27.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kammer G. M., Soter N. A., Gibson D. J., Schur P. H. Psoriatic arthritis: a clinical, immunologic and HLA study of 100 patients. Semin Arthritis Rheum. 1979 Nov;9(2):75–97. doi: 10.1016/s0049-0172(79)80001-3. [DOI] [PubMed] [Google Scholar]
- Lambert J. R., Wright V. Psoriatic spondylitis: a clinical and radiological description of the spine in psoriatic arthritis. Q J Med. 1977 Oct;46(184):411–425. [PubMed] [Google Scholar]
- Leonard D. G., O'Duffy J. D., Rogers R. S. Prospective analysis of psoriatic arthritis in patients hospitalized for psoriasis. Mayo Clin Proc. 1978 Aug;53(8):511–518. [PubMed] [Google Scholar]
- McEwen C., DiTata D., Lingg C., Porini A., Good A., Rankin T. Ankylosing spondylitis and spondylitis accompanying ulcerative colitis, regional enteritis, psoriasis and Reiter's disease. A comparative study. Arthritis Rheum. 1971 May-Jun;14(3):291–318. doi: 10.1002/art.1780140302. [DOI] [PubMed] [Google Scholar]
- Miller M. H., Lee P., Smythe H. A., Goldsmith C. H. Measurements of spinal mobility in the sagittal plane: new skin contraction technique compared with established methods. J Rheumatol. 1984 Aug;11(4):507–511. [PubMed] [Google Scholar]
- Moll J. M., Wright V. Psoriatic arthritis. Semin Arthritis Rheum. 1973;3(1):55–78. doi: 10.1016/0049-0172(73)90035-8. [DOI] [PubMed] [Google Scholar]
- Pittsley R. A., Yoder F. W. Retinoid hyperostosis. Skeletal toxicity associated with long-term administration of 13-cis-retinoic acid for refractory ichthyosis. N Engl J Med. 1983 Apr 28;308(17):1012–1014. doi: 10.1056/NEJM198304283081707. [DOI] [PubMed] [Google Scholar]
- REED W. B. Psoriatic arthritis. A complete clinical study of 86 patients. Acta Derm Venereol. 1961;41:396–403. [PubMed] [Google Scholar]
- Resnick D., Niwayama G. Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology. 1976 Jun;119(3):559–568. doi: 10.1148/119.3.559. [DOI] [PubMed] [Google Scholar]
- Riley M. J., Ansell B. M., Bywaters E. G. Radiological manifestations of ankylosing spondylitis according to age at onset. Ann Rheum Dis. 1971 Mar;30(2):138–148. doi: 10.1136/ard.30.2.138. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schlosstein L., Terasaki P. I., Bluestone R., Pearson C. M. High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med. 1973 Apr 5;288(14):704–706. doi: 10.1056/NEJM197304052881403. [DOI] [PubMed] [Google Scholar]
- WETTSTEIN P., RIOTTON G. Aspects anatomo-radiologiques de la spondylarthrite ankylosante. Radiol Clin. 1950 Sep;19(5):325–331. [PubMed] [Google Scholar]