Abstract
Two patients with rheumatoid arthritis developed pancytopenia during treatment with azathioprine 100 mg daily. In one patient this side effect occurred after three weeks, in the other after eight weeks of treatment. Rapid fall of platelets in one patient necessitated platelet transfusion. In the other patient additional treatment with allopurinol was probably responsible for the toxic effect. Haematological side effects of azathioprine are discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Glogner P., Heni N. Panzytopenie nach Kombinationsbehandlung mit Allopurinol und Azathioprin. Med Welt. 1976 Aug 13;27(33):1545–1546. [PubMed] [Google Scholar]
- Old C. W., Flannery E. P., Grogan T. M., Stone W. H., San Antonio R. P. Azathioprine-induced pure red blood cell aplasia. JAMA. 1978 Aug 11;240(6):552–554. [PubMed] [Google Scholar]
- Reinicke H., Weber F. W., Hausamen T. U. Myelosuppression mit makrozytärer Anämie und Leukopenie unter Behandlung mit Azathioprin bei Myasthenia gravis. Dtsch Med Wochenschr. 1982 Oct 22;107(42):1592–1594. doi: 10.1055/s-2008-1070172. [DOI] [PubMed] [Google Scholar]
- Whisnant J. K., Pelkey J. Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities. Ann Rheum Dis. 1982;41 (Suppl 1):44–47. doi: 10.1136/ard.41.suppl_1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]