Abstract
Reduced in vitro anti-influenza antibody response by peripheral blood mononuclear cells (PBMs) after vaccination was confirmed in a group of 28 patients with systemic lupus erythematosus (SLE), and also in 16 patients with some other autoimmune syndromes. This group of patients with SLE had higher serum anti-DNA binding, but there was no evidence of increased autoantibody production after vaccination, nor any clinical or laboratory evidence of flares in disease activity that are sometimes seen to follow intercurrent infection. Although a reduced in vitro antibody response may, to some extent, reflect redistribution of antibody producing cells, there appears to be more generalised impairment of the immune response in these patients, which cannot be accounted for by steroid/immunosuppressive therapy.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Callard R. E., Smith C. M. Histocompatibility requirements for T cell help in specific in vitro antibody responses to influenza virus by human blood lymphocytes. Eur J Immunol. 1981 Mar;11(3):206–212. doi: 10.1002/eji.1830110309. [DOI] [PubMed] [Google Scholar]
- Callard R. E. Specific in vitro antibody response to influenza virus by human blood lymphocytes. Nature. 1979 Dec 13;282(5740):734–736. doi: 10.1038/282734a0. [DOI] [PubMed] [Google Scholar]
- Fauci A. S., Steinberg A. D., Haynes B. F., Whalen G. Immunoregulatory aberrations in systemic lupus erythematosus. J Immunol. 1978 Oct;121(4):1473–1479. [PubMed] [Google Scholar]
- Hari Kumar M. K., Knight R. A., Snaith M. L. Specific allogeneic help by T lymphocytes from patients with systemic lupus erythematosus. Clin Exp Immunol. 1984 Oct;58(1):21–28. [PMC free article] [PubMed] [Google Scholar]
- Isenberg D. A., Maddison P., Swana G., Skinner R. P., Swana M., Jones M., Addison I., Dudeney C., Shall S., el Roiey A. Profile of autoantibodies in the serum of patients with tuberculosis, klebsiella and other gram-negative infections. Clin Exp Immunol. 1987 Mar;67(3):516–523. [PMC free article] [PubMed] [Google Scholar]
- Nies K. M., Louie J. S. Impaired immunoglobulin synthesis by peripheral blood lymphocytes in systemic lupus erythematosus. Arthritis Rheum. 1978 Jan-Feb;21(1):51–57. doi: 10.1002/art.1780210109. [DOI] [PubMed] [Google Scholar]
- Souhami R. L., Babbage J., Sigfusson A. Defective in vitro antibody production to Varicella zoster and other virus antigens in patients with Hodgkin's disease. Clin Exp Immunol. 1983 Aug;53(2):297–307. [PMC free article] [PubMed] [Google Scholar]
- Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]