Table 1.
Shows genes in human immune cells that are not found in inbred mice, and thus may mediate novel mechanisms. But note many are shared with rats, and thus are likely not related to longevity, but nonetheless may mediate important functions in human beings.
| Gene | Immune population | The human protein atlas tissue specificity | Group | Top blastp against mouse | ||||
|---|---|---|---|---|---|---|---|---|
| GLYATL1B | B naive | breast, lymphoid tissue | glycine-N-acyltransferase-like 1B | 0.412 | primates | – | – | – |
| ZNF860 | B naive + memory | lymphoid tissue | zinc fingers C2H2-type | 0.438 | primates | – | – | – |
| PLEKHG7 | B naive + memory | cervix, epididymis, fallopian tube | Pleckstrin homology domain containing/Dbl family Rho GEFs | 0.258 | mammals | rats | sea urchins | – |
| PLAAT2 | plasmablasts | intestine | phospholipase A and acyltransferase family | primates | – | – | – | |
| ZNF683 | T CD8 TE | testis | zinc fingers C2H2-type | 0.56 | mammals | rats | – | – |
| TRABD2A | T naive | intestine, lymphoid tissue, ovary | TraB domain containing 2A | 0.648 | broad | fish | – | – |
| FAAH2 | Tfh + Th | multiple tissues including lymphoid | fatty acid amide hydrolase 2 | 0.304 | broad | fish | Drosph | xeno |
| GNLY | T, NK | bone marrow, lymphoid tissue | granulysin, cytotoxic T cells, NK cells | 0.292 | broad | – | – | – |
| KIR2DP1 | NK | lymphoid tissue | killer cell immunoglobulin like receptors | 0.401 | mammals | – | – | – |
| KLRF1 | NK | bone marrow, lymphoid tissue | killer cell lectin like receptors/C-type lectin domain containing | 0.303 | mammals | – | – | – |
| LGALS9B | NK | esophagus, intestine, stomach 1 | galectins | 0.685 | – | – | – | – |
| LGALS9C | NK | esophagus, intestine, stomach 1 | galectins | 0.688 | – | – | – | – |
| CD1B | mDCs | lymphoid tissue | CD molecules/C1-set domain containing | 0.489 | mammals | – | – | – |
| CD1E | mDCs | lymphoid tissue | CD molecules/C1-set domain containing | 0.521 | mammals | bats | chinchilla | – |
| CLIC2 | mDCs | multiple tissues including lymphoid | chloride intracellular channels | 0.662 | broad | rats | – | – |
| KCNK17 | pDCs | lung, thyroid gland | potassium two pore domain channel subfamily K | 0.42 | broad | Drosophila | – | – |
| NLRP7 | pDCs | testis | NLR family/pyrin domain containing | 0.408 | mammals | – | – | – |
| CTSV | pDCs | lymphoid tissue | cathepsins | 0.792 | mammals | mole rat | – | – |
| PROC | pDCs | liver | receptor ligands/Gla domain containing | 0.695 | mammals | rats | – | – |
| SLC9C2 | pDCs | brain, choroid plexus, testis | solute carriers | 0.292 | mammals | rats | – | – |
| ADGRE3 | granulocytes LD | bone marrow, lymphoid tissue | adhesion G protein-coupled receptors, subfamily E | 0.459 | mammals | – | – | – |
| NT5DC4 | monocytes I | testis | 50-nucleotidase domain containing 4 | 0.654 | broad | – | – | – |
| CASP5 | monocytes NC | brain, intestine, lymphoid tissue | caspases|caspase recruitment domain containing | 0.636 | broad | – | – | – |
| LILRA1 | monocytes NC + I | lymphoid tissue | CD molecules/activating leukocyte immunoglobulin like receptors | 0.507 | primates | – | – | – |
| LILRB2 | monocytes NC + I | bone marrow, lung, lymphoid tissue | CD molecules/inhibitory leukocyte immunoglobulin-like receptors/Ig-like cell adhesion molecule family | 0.452 | mammals | rats | – | – |
| LILRA2 | myeloid | bone marrow, lymphoid tissue | CD molecules/activating leukocyte immunoglobulin like receptors | 0.513 | primates | – | – | – |
| SIGLEC14 | myeloid | bone marrow, lymphoid tissue | V-set domain containing/sialic acid binding Ig-like lectins | 0.498 | mammals | |||
| – | – | lung, lymphoid tissue | – | – | – | – | – | – |
| OR14L1P | basophils LD | brain | olfactory receptors, family 14 | 0.53 | mammals | reptiles | – | – |
| OR6K3 | basophils LD | bone marrow | olfactory receptors, family 6 | 0.784 | mammals | rats | – | – |
| OXER1 | basophils LD | liver | leukotriene receptors | 0.418 | mammals | – | – | – |
| TRIM49D1 | basophils LD | undetected | ring finger proteins/tripartite motif containing | 0.364 | primates | – | – | – |
| TRIM49D2 | basophils LD | undetected | ring finger proteins/tripartite motif containing | 0.364 | primates | – | – | – |
| TRIM51 | basophils LD | undetected | ring finger proteins/tripartite motif containing | 0.367 | – | – | – | – |
| TRIM64 | basophils LD | placenta | ring finger proteins/tripartite motif containing | 0.348 | – | – | – | – |
| TRIM64B | basophils LD | placenta | ring finger proteins/tripartite motif containing | 0.348 | – | – | – | – |
| FCAR | neutrophils LD | bone marrow, lung, lymphoid tissue | CD molecules/immunoglobulin-like domain containing/Fc receptors | 0.327 | – | – | – | – |
| H2AC19 | neutrophils LD | multiple tissues including lymphoid | H2A histones | 1 | – | – | – | – |
| CSNK1A1L | neutrophils LD | testis | casein kinase 1 family | 0.91 | broad | Drosophila | – | – |
| LINC02218 | neutrophils LD | undetected | long intergenic non-protein coding RNAs | 0.441 | – | – | – | – |
| PEAK3 | neutrophils LD | bone marrow, lymphoid tissue | PEAK family member 3 | 0.268 | broad | fish | – | – |
| PI3 | neutrophils LD | esophagus, lymphoid tissue, vagina | WAP four-disulfide core domain containing | 0.941 | broad | chkns | – | – |
| S100A12 | neutrophils LD | bone marrow | S100 calcium binding proteins/EF-hand domain containing | 0.388 | mammals | rats | – | – |
| SIRPB2 | neutrophils LD | lymphoid tissue | V-set domain containing/signal regulatory proteins | 0.348 | mammals | rats | – | – |
| SIRPD | neutrophils LD | testis | V-set domain containing/signal regulatory proteins | 0.48 | mammals | rats | – | – |
| ST20 | neutrophils LD | multiple tissues including lymphoid | suppressor of tumorigenicity 20 | 0.724 | ? | – | – | – |
| TMEM272 | neutrophils LD | brain | transmembrane protein 272 | 0.368 | mammals | – | – | – |