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. 1988 Sep;47(9):764–767. doi: 10.1136/ard.47.9.764

Adult onset Still's disease and viral infections.

J M Wouters 1, J van der Veen 1, L B van de Putte 1, D J de Rooij 1
PMCID: PMC1003594  PMID: 3178317

Abstract

Several micro-organisms, especially viruses, have been associated with juvenile and adult onset Still's disease. In the present study a search for probable triggering viral infections in five consecutive patients with early, active adult onset Still's disease has been made. In one patient echovirus 7 was identified as a probable triggering agent. Evidence of infection with this virus was acquired by virus cultures and serological tests. In two patients the illness was probably initiated by a rubella reinfection. Both had initially high stable monospecific IgG antibody titres but no IgM antibodies to this virus. In the remaining two cases no particular triggering viral infection could be designated. Evidence of a viral infection was thus found in three of these five patients. Adult onset Still's disease may represent a reaction pattern to certain infections.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Balfour H. H., Jr, Groth K. E., Edelman C. K., Amren D. P., Best J. M., Banatvala J. E. Rubella viraemia and antibody responses after rubella vaccination and reimmunization. Lancet. 1981 May 16;1(8229):1078–1080. doi: 10.1016/s0140-6736(81)92243-1. [DOI] [PubMed] [Google Scholar]
  2. Barnert A. L., Terry E. E., Persellin R. H. Acute rheumatic fever in adults. JAMA. 1975 Jun 2;232(9):925–928. [PubMed] [Google Scholar]
  3. Blotzer J. W., Myers A. R. Echovirus-associated polyarthritis. Report of a case with synovial fluid and synovial histologic characterization. Arthritis Rheum. 1978 Nov-Dec;21(8):978–981. doi: 10.1002/art.1780210817. [DOI] [PubMed] [Google Scholar]
  4. Calabro J. J., Holgerson W. B., Sonpal G. M., Khoury M. I. Juvenile rheumatoid arthritis: a general review and report of 100 patients observed for 15 years. Semin Arthritis Rheum. 1976 Feb;5(3):257–298. doi: 10.1016/0049-0172(76)90027-5. [DOI] [PubMed] [Google Scholar]
  5. Chantler J. K., Ford D. K., Tingle A. J. Persistent rubella infection and rubella-associated arthritis. Lancet. 1982 Jun 12;1(8285):1323–1325. doi: 10.1016/s0140-6736(82)92398-4. [DOI] [PubMed] [Google Scholar]
  6. Chantler J. K., Tingle A. J., Petty R. E. Persistent rubella virus infection associated with chronic arthritis in children. N Engl J Med. 1985 Oct 31;313(18):1117–1123. doi: 10.1056/NEJM198510313131803. [DOI] [PubMed] [Google Scholar]
  7. Colebunders R., Stevens W. J., Vanagt E., Snoeck J. Adult Still's disease caused by Yersinia enterocolitica infection. Arch Intern Med. 1984 Sep;144(9):1880–1882. [PubMed] [Google Scholar]
  8. Conyn-van Spaendonck M. A., Hannik C. A., Bijkerk H., van Noorle Jansen L. M., Plantinga A. D., van Steenis G., van Wezel A. L., Ruitenberg E. J. Immuunstatus in 1980 van de Nederlandse bevolking vanaf 10 jaar tegen poliomyelitis, rubella en morbilli; een serologisch onderzoek. Ned Tijdschr Geneeskd. 1984 Oct 6;128(40):1884–1887. [PubMed] [Google Scholar]
  9. Dold U., Haelbig C. Mykoplasmose und Still-Syndrom. Gibt es einen ätiologischen zusammenhang? MMW Munch Med Wochenschr. 1981 Dec 4;123(49):1908–1909. [PubMed] [Google Scholar]
  10. Gordon S. C., Lauter C. B. Mumps arthritis: unusual presentation as adult Still's disease. Ann Intern Med. 1982 Jul;97(1):45–47. doi: 10.7326/0003-4819-97-1-45. [DOI] [PubMed] [Google Scholar]
  11. Grahame R., Armstrong R., Simmons N., Wilton J. M., Dyson M., Laurent R., Millis R., Mims C. A. Chronic arthritis associated with the presence of intrasynovial rubella virus. Ann Rheum Dis. 1983 Feb;42(1):2–13. doi: 10.1136/ard.42.1.2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Harth M., Thompson J. M., Ralph E. D. Adult-onset Still's disease. Can Med Assoc J. 1979 Jun 23;120(12):1507–1510. [PMC free article] [PubMed] [Google Scholar]
  13. Heaton D. C., Moller P. W. Still's disease associated with Coxsackie infection and haemophagocytic syndrome. Ann Rheum Dis. 1985 May;44(5):341–344. doi: 10.1136/ard.44.5.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Horstmann D. M., Liebhaber H., Le Bouvier G. L., Rosenberg D. A., Halstead S. B. Rubella: reinfection of vaccinated and naturally immune persons exposed in an epidemic. N Engl J Med. 1970 Oct 8;283(15):771–778. doi: 10.1056/NEJM197010082831501. [DOI] [PubMed] [Google Scholar]
  15. Huang S. H., DeCoteau W. E. Adult-onset Still's disease: an unusual presentation of rubella infection. Can Med Assoc J. 1980 Jun 7;122(11):1275–1276. [PMC free article] [PubMed] [Google Scholar]
  16. Larson E. B. Adult Still's disease. Evolution of a clinical syndrome and diagnosis, treatment, and follow-up of 17 patients. Medicine (Baltimore) 1984 Mar;63(2):82–91. [PubMed] [Google Scholar]
  17. Linnemann C. C., Jr, Levinson J. E., Buncher C. R., Schiff G. M. Rubella antibody levels in juvenile rheumatoid arthritis. Ann Rheum Dis. 1975 Aug;34(4):354–358. doi: 10.1136/ard.34.4.354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Medsger T. A., Jr, Christy W. C. Carpal arthritis with ankylosis in late onset Still's disease. Arthritis Rheum. 1976 Mar-Apr;19(2):232–242. doi: 10.1002/art.1780190216. [DOI] [PubMed] [Google Scholar]
  19. Miller M. L., Aaron S., Jackson J., Fraser P., Cairns L., Hoch S., Borel Y., Larson M., Glass D. N. HLA gene frequencies in children and adults with systemic onset juvenile rheumatoid arthritis. Arthritis Rheum. 1985 Feb;28(2):146–150. doi: 10.1002/art.1780280207. [DOI] [PubMed] [Google Scholar]
  20. Ogra P. L., Chiba Y., Ogra S. S., Dzierba J. L., Herd J. K. Rubella-virus infection in juvenile rheumatoid arthritis. Lancet. 1975 May 24;1(7917):1157–1161. doi: 10.1016/s0140-6736(75)93136-0. [DOI] [PubMed] [Google Scholar]
  21. Rahal J. J., Millian S. J., Noriega E. R. Coxsackievirus and adenovirus infection. Association with acute febrile and juvenile rheumatoid arthritis. JAMA. 1976 Jun 7;235(23):2496–2501. doi: 10.1001/jama.235.23.2496. [DOI] [PubMed] [Google Scholar]
  22. Terkeltaub R., Esdaile J. M., Décary F., Harth M., Lister J., Lapointe N. HLA-Bw35 and prognosis in adult Still's disease. Arthritis Rheum. 1981 Dec;24(12):1469–1472. doi: 10.1002/art.1780241203. [DOI] [PubMed] [Google Scholar]
  23. Tingle A. J., Ford D. K., Price G. E., Kettyls D. W. Prolonged arthritis in identical twins after rubella immunization. Ann Intern Med. 1979 Feb;90(2):203–204. doi: 10.7326/0003-4819-90-2-203. [DOI] [PubMed] [Google Scholar]
  24. Valtonen V. V., Leirisalo M., Pentikäinen P. J., Räsänen T., Seppälä I., Larinkari U., Ranki M., Koskimies S., Malkamäki M., Mäkelä P. H. Triggering infections in reactive arthritis. Ann Rheum Dis. 1985 Jun;44(6):399–405. doi: 10.1136/ard.44.6.399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Wilkins J., Leedom J. M., Salvatore M. A., Portnoy B. Clinical rubella with arthritis resulting from reinfection. Ann Intern Med. 1972 Dec;77(6):930–932. doi: 10.7326/0003-4819-77-6-930. [DOI] [PubMed] [Google Scholar]
  26. Wouters J. M., Reekers P., van de Putte L. B. Adult-onset Still's disease. Disease course and HLA associations. Arthritis Rheum. 1986 Mar;29(3):415–418. doi: 10.1002/art.1780290316. [DOI] [PubMed] [Google Scholar]
  27. de Vere-Tyndall A., Bacon T., Parry R., Tyrrell D. A., Denman A. M., Ansell B. M. Infection and interferon production in systemic juvenile chronic arthritis: a prospective study. Ann Rheum Dis. 1984 Feb;43(1):1–7. doi: 10.1136/ard.43.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]

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