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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1988 Oct;47(10):869–872. doi: 10.1136/ard.47.10.869

Pulmonary haemorrhage, pulmonary infarction, and the lupus anticoagulant.

H S Howe 1, M L Boey 1, K Y Fong 1, P H Feng 1
PMCID: PMC1003619  PMID: 3143319

Abstract

A patient with systemic lupus erythematosus developed pulmonary haemorrhage and pulmonary infarction as rare initial manifestations of her disease. The latter was associated with the presence of the circulating lupus anticoagulant. She recovered with pulse doses of methylprednisolone and plasmapheresis. Anticoagulants were not administered.

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Selected References

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  1. Abud-Mendoza C., Diaz-Jouanen E., Alarcón-Segovia D. Fatal pulmonary hemorrhage in systemic lupus erythematosus. Occurrence without hemoptysis. J Rheumatol. 1985 Jun;12(3):558–561. [PubMed] [Google Scholar]
  2. Asherson R. A., Mackay I. R., Harris E. N. Myocardial infarction in a young man with systemic lupus erythematosus, deep vein thrombosis, and antibodies to phospholipid. Br Heart J. 1986 Aug;56(2):190–193. doi: 10.1136/hrt.56.2.190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Averbuch M., Levo Y. Budd-Chiari syndrome as the major thrombotic complication of systemic lupus erythematosus with the lupus anticoagulant. Ann Rheum Dis. 1986 May;45(5):435–437. doi: 10.1136/ard.45.5.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Boey M. L., Colaco C. B., Gharavi A. E., Elkon K. B., Loizou S., Hughes G. R. Thrombosis in systemic lupus erythematosus: striking association with the presence of circulating lupus anticoagulant. Br Med J (Clin Res Ed) 1983 Oct 8;287(6398):1021–1023. doi: 10.1136/bmj.287.6398.1021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Carette S., Macher A. M., Nussbaum A., Plotz P. H. Severe, acute pulmonary disease in patients with systemic lupus erythematosus: ten years of experience at the National Institutes of Health. Semin Arthritis Rheum. 1984 Aug;14(1):52–59. doi: 10.1016/0049-0172(84)90009-x. [DOI] [PubMed] [Google Scholar]
  6. Castañeda S., Herrero-Beaumont G., Valenzuela A., Vidal J., Moldenhauer F., Renedo G., Fernández-Vallado P. Massive pulmonary hemorrhage: fatal complication of systemic lupus erythematosus. J Rheumatol. 1985 Feb;12(1):186–187. [PubMed] [Google Scholar]
  7. Churg A., Franklin W., Chan K. L., Kopp E., Carrington C. B. Pulmonary hemorrhage and immune-complex deposition in the lung. Complications in a patient with systemic lupus erythematosus. Arch Pathol Lab Med. 1980 Jul;104(7):388–391. [PubMed] [Google Scholar]
  8. Derksen R. H., Bouma B. N., Kater L. The association between the lupus anticoagulant and cerebral infarction in systemic lupus erythematosus. Scand J Rheumatol. 1986;15(2):179–184. doi: 10.3109/03009748609102086. [DOI] [PubMed] [Google Scholar]
  9. Eagen J. W., Memoli V. A., Roberts J. L., Matthew G. R., Schwartz M. M., Lewis E. J. Pulmonary hemorrhage in systemic lupus erythematosus. Medicine (Baltimore) 1978 Nov;57(6):545–560. doi: 10.1097/00005792-197811000-00005. [DOI] [PubMed] [Google Scholar]
  10. Eagen J. W., Roberts J. L., Schwartz M. M., Lewis E. J. The composition of pulmonary immune deposits in systemic lupus erythematosus. Clin Immunol Immunopathol. 1979 Feb;12(2):204–219. doi: 10.1016/0090-1229(79)90009-6. [DOI] [PubMed] [Google Scholar]
  11. Espinoza L. R., Hartmann R. C. Significance of the lupus anticoagulant. Am J Hematol. 1986 Jul;22(3):331–337. doi: 10.1002/ajh.2830220315. [DOI] [PubMed] [Google Scholar]
  12. Glueck H. I., Kant K. S., Weiss M. A., Pollak V. E., Miller M. A., Coots M. Thrombosis in systemic lupus erythematosus. Relation to the presence of circulating anticoagulants. Arch Intern Med. 1985 Aug;145(8):1389–1395. [PubMed] [Google Scholar]
  13. Gould D. B., Soriano R. Z. Acute alveolar hemorrhage in lupus erythematosus. Ann Intern Med. 1975 Dec;83(6):836–837. doi: 10.7326/0003-4819-83-6-836. [DOI] [PubMed] [Google Scholar]
  14. Leatherman J. W., Davies S. F., Hoidal J. R. Alveolar hemorrhage syndromes: diffuse microvascular lung hemorrhage in immune and idiopathic disorders. Medicine (Baltimore) 1984 Nov;63(6):343–361. [PubMed] [Google Scholar]
  15. Millman R. P., Cohen T. B., Levinson A. I., Kelley M. A., Sachs M. L. Systemic lupus erythematosus complicated by acute pulmonary hemorrhage: recovery following plasmapheresis and cytotoxic therapy. J Rheumatol. 1981 Nov-Dec;8(6):1021–1023. [PubMed] [Google Scholar]
  16. Mintz G., Galindo L. F., Fernández-Diez J., Jiménez F. J., Robles-Saavedra E., Enríquez-Casillas R. D. Acute massive pulmonary hemorrhage in systemic lupus erythematosus. J Rheumatol. 1978 Spring;5(1):39–50. [PubMed] [Google Scholar]
  17. Myers J. L., Katzenstein A. A. Microangiitis in lupus-induced pulmonary hemorrhage. Am J Clin Pathol. 1986 May;85(5):552–556. doi: 10.1093/ajcp/85.5.552. [DOI] [PubMed] [Google Scholar]
  18. Pauzner R., Rosner E., Many A. Circulating anticoagulant in systemic lupus erythematosus: clinical manifestations. Acta Haematol. 1986;76(2-3):90–94. doi: 10.1159/000206028. [DOI] [PubMed] [Google Scholar]

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