Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1990 Mar;49(3):181–183. doi: 10.1136/ard.49.3.181

Systemic lupus erythematosus presenting as pneumococcal septicaemia and septic arthritis.

J Webster 1, B D Williams 1, A P Smith 1, M Hall 1, J D Jessop 1
PMCID: PMC1004017  PMID: 2322028

Abstract

A 50 year old woman presented with pneumococcal septicaemia, septic arthritis, and a lobar pneumonia and was subsequently diagnosed as having systemic lupus erythematosus. The blood film and splenic 99mTc sulphur colloid uptake were normal, although selective functional hyposplenism was shown by the impaired clearance of immunoglobulin coated erythrocytes. Systemic lupus erythematosus presenting with fulminating pneumococcal sepsis in the presence of selective defects in spleen function is previously unreported.

Full text

PDF
181

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amlot P. L., Hayes A. E. Impaired human antibody response to the thymus-independent antigen, DNP-Ficoll, after splenectomy. Implications for post-splenectomy infections. Lancet. 1985 May 4;1(8436):1008–1011. doi: 10.1016/s0140-6736(85)91613-7. [DOI] [PubMed] [Google Scholar]
  2. Brown E. J., Hosea S. W., Frank M. M. The role of the spleen in experimental pneumococcal bacteremia. J Clin Invest. 1981 Apr;67(4):975–982. doi: 10.1172/JCI110148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brown E. J., Joiner K. A., Frank M. M. The role of complement in host resistance to bacteria. Springer Semin Immunopathol. 1983;6(4):349–360. doi: 10.1007/BF02116279. [DOI] [PubMed] [Google Scholar]
  4. Burman L. A., Norrby R., Trollfors B. Invasive pneumococcal infections: incidence, predisposing factors, and prognosis. Rev Infect Dis. 1985 Mar-Apr;7(2):133–142. doi: 10.1093/clinids/7.2.133. [DOI] [PubMed] [Google Scholar]
  5. Dillon A. M., Stein H. B., English R. A. Splenic atrophy in systemic lupus erythematosus. Ann Intern Med. 1982 Jan;96(1):40–43. doi: 10.7326/0003-4819-96-1-40. [DOI] [PubMed] [Google Scholar]
  6. Dillon A. M., Stein H. B., Kassen B. O., Ibbott J. W. Hyposplenia in a patient with systemic lupus erythematosus. J Rheumatol. 1980 Mar-Apr;7(2):196–198. [PubMed] [Google Scholar]
  7. Edelen J. S., Lockshin M. D., LeRoy E. C. Gonococcal arthritis in two patients with active lupus erythematosus. A diagnostic problem. Arthritis Rheum. 1971 Sep-Oct;14(5):557–559. doi: 10.1002/art.1780140502. [DOI] [PubMed] [Google Scholar]
  8. Eraklis A. J., Kevy S. V., Diamond L. K., Gross R. E. Hazard of overwhelming infection after splenectomy in childhood. N Engl J Med. 1967 Jun 1;276(22):1225–1229. doi: 10.1056/NEJM196706012762203. [DOI] [PubMed] [Google Scholar]
  9. Frank M. M., Lawley T. J., Hamburger M. I., Brown E. J. NIH Conference: Immunoglobulin G Fc receptor-mediated clearance in autoimmune diseases. Ann Intern Med. 1983 Feb;98(2):206–218. doi: 10.7326/0003-4819-98-2-218. [DOI] [PubMed] [Google Scholar]
  10. Ginzler E., Diamond H., Kaplan D., Weiner M., Schlesinger M., Seleznick M. Computer analysis of factors influencing frequency of infection in systemic lupus erythematosus. Arthritis Rheum. 1978 Jan-Feb;21(1):37–44. doi: 10.1002/art.1780210107. [DOI] [PubMed] [Google Scholar]
  11. Gransden W. R., Eykyn S. J., Phillips I. Pneumococcal bacteraemia: 325 episodes diagnosed at St Thomas's Hospital. Br Med J (Clin Res Ed) 1985 Feb 16;290(6467):505–508. doi: 10.1136/bmj.290.6467.505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Guckian J. C., Byers E. H., Perry J. E. Arizona infection of man. Report of a case and review of the literature. Arch Intern Med. 1967 Feb;119(2):170–175. [PubMed] [Google Scholar]
  13. KING H., SHUMACKER H. B., Jr Splenic studies. I. Susceptibility to infection after splenectomy performed in infancy. Ann Surg. 1952 Aug;136(2):239–242. doi: 10.1097/00000658-195208000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Pines A., Kaplinsky N., Olchovsky D., Holtzman E., Frankl O. Hyposplenism in systemic lupus erythematosus. Br J Rheumatol. 1983 Aug;22(3):176–178. doi: 10.1093/rheumatology/22.3.176. [DOI] [PubMed] [Google Scholar]
  15. Quismorio F. P., Dubois E. L. Septic arthritis in systemic lupus erythematosus. J Rheumatol. 1975 Mar;2(1):73–82. [PubMed] [Google Scholar]
  16. Schenfeld L., Gray R. G., Poppo M. J., Gaylis N. B., Gottlieb N. L. Bacterial monarthritis due to Neisseria meningitidis in systemic lupus erythematosus. J Rheumatol. 1981 Jan-Feb;8(1):145–148. [PubMed] [Google Scholar]
  17. Staples P. J., Gerding D. N., Decker J. L., Gordon R. S., Jr Incidence of infection in systemic lupus erythematosus. Arthritis Rheum. 1974 Jan-Feb;17(1):1–10. doi: 10.1002/art.1780170102. [DOI] [PubMed] [Google Scholar]
  18. Yousaf N., Howard J. C., Williams B. D. Studies in the rat of antibody-coated and N-ethylmaleimide-treated erythrocyte clearance by the spleen. I. Effects of in vivo complement activation. Immunology. 1986 Sep;59(1):75–79. [PMC free article] [PubMed] [Google Scholar]
  19. Yousaf N., Howard J. C., Williams B. D. Studies in the rat of antibody-coated and N-ethylmaleimide-treated erythrocyte clearance by the spleen. II. Effects of immune complex infusion. Immunology. 1986 Sep;59(1):81–85. [PMC free article] [PubMed] [Google Scholar]
  20. Yousaf N., Howard J. C., Williams B. D. Studies in the rat of antibody-sensitized and N-ethylmaleimide-treated erythrocyte clearance by the liver: effects of immune complex infusion and complement activation. Immunology. 1988 Jun;64(2):193–199. [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES