Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1990 Apr;49(4):265–267. doi: 10.1136/ard.49.4.265

Pulse methylprednisolone therapy in rheumatoid arthritis: unproved therapy, unjustified therapy, or effective adjunctive treatment?

M D Smith 1, M J Ahern 1, P J Roberts-Thomson 1
PMCID: PMC1004053  PMID: 2187419

Full text

PDF
265

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barry M. The use of high-dose pulse methylprednisolone in rheumatoid arthritis. Unproved therapy. Arch Intern Med. 1985 Aug;145(8):1483–1484. [PubMed] [Google Scholar]
  2. Baylis E. M., Williams I. A., English J., Marks V., Chakraborty J. High dose intravenous methylprednisolone "pulse" therapy in patients with rheumatoid disease. Plasma methylprednisolone levels and adrenal function. Eur J Clin Pharmacol. 1982;21(5):385–388. doi: 10.1007/BF00542323. [DOI] [PubMed] [Google Scholar]
  3. Bertouch J. V., Meffin P. J., Sallustio B. C., Brooks P. M. A comparison of plasma methylprednisolone concentrations following intra-articular injection in patients with rheumatoid arthritis and osteoarthritis. Aust N Z J Med. 1983 Dec;13(6):583–586. doi: 10.1111/j.1445-5994.1983.tb02608.x. [DOI] [PubMed] [Google Scholar]
  4. Bertouch J. V., Roberts-Thomson P. J., Smith M. D., Woodruff T. G., Brooks P. M., Bradley J. Methylprednisolone infusion therapy in rheumatoid arthritis patients. The effect on synovial fluid lymphocyte subsets and inflammatory indices. Arthritis Rheum. 1986 Jan;29(1):32–38. doi: 10.1002/art.1780290105. [DOI] [PubMed] [Google Scholar]
  5. Bijlsma J. W., Duursma S. A., Huber-Bruning O. Bone metabolism during methylprednisolone pulse therapy in rheumatoid arthritis. Ann Rheum Dis. 1986 Sep;45(9):757–760. doi: 10.1136/ard.45.9.757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Corticosteroid treatment in rheumatoid arthritis. Br J Rheumatol. 1985 Nov;24(4):379–380. [PubMed] [Google Scholar]
  7. Fan P. T., Yu D. T., Clements P. J., Fowlston S., Eisman J., Bluestone R. Effect of corticosteroids on the human immune response: comparison of one and three daily 1 gm intravenous pulses of methylprednisolone. J Lab Clin Med. 1978 Apr;91(4):625–634. [PubMed] [Google Scholar]
  8. Forster P. J., Grindulis K. A., Neumann V., Hubball S., McConkey B. High-dose intravenous methylprednisolone in rheumatoid arthritis. Ann Rheum Dis. 1982 Oct;41(5):444–446. doi: 10.1136/ard.41.5.444. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hansen T. M., Dickmeiss E., Jans H., Ingemann Hansen T., Ingeman-Nielsen M., Lorenzen I. Combination of methylprednisolone pulse therapy and remission inducing drugs in rheumatoid arthritis. Ann Rheum Dis. 1987 Apr;46(4):290–295. doi: 10.1136/ard.46.4.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jones J. G. Avascular necrosis and pulsed methylprednisolone in RA. Br J Rheumatol. 1988 Dec;27(6):497–498. doi: 10.1093/rheumatology/27.6.497. [DOI] [PubMed] [Google Scholar]
  11. Kraus A. Pulse steroid therapy, rheumatoid arthritis and the Journal of Rheumatology. J Rheumatol. 1988 Dec;15(12):1872–1874. [PubMed] [Google Scholar]
  12. Liebling M. R., Leib E., McLaughlin K., Blocka K., Furst D. E., Nyman K., Paulus H. E. Pulse methylprednisolone in rheumatoid arthritis: a double-blind cross-over trial. Ann Intern Med. 1981 Jan;94(1):21–26. doi: 10.7326/0003-4819-94-1-21. [DOI] [PubMed] [Google Scholar]
  13. Lockie L. M., Smith D. M. Forty-seven years experience with gold therapy in 1,019 rheumatoid arthritis patients. Semin Arthritis Rheum. 1985 May;14(4):238–246. doi: 10.1016/0049-0172(85)90043-5. [DOI] [PubMed] [Google Scholar]
  14. Myles A. Corticosteroid treatment in rheumatoid arthritis. Br J Rheumatol. 1985 May;24(2):125–127. doi: 10.1093/rheumatology/24.2.125. [DOI] [PubMed] [Google Scholar]
  15. Needs C. J., Smith M., Boutagy J., Donovan S., Cosh D., McCredie M., Brooks P. M. Comparison of methylprednisolone (1 g i.v.) with prednisolone (1 g orally) in rheumatoid arthritis: a pharmacokinetic and clinical study. J Rheumatol. 1988 Feb;15(2):224–228. [PubMed] [Google Scholar]
  16. Neumann V., Hopkins R., Dixon J., Watkins A., Bird H., Wright V. Combination therapy with pulsed methylprednisolone in rheumatoid arthritis. Ann Rheum Dis. 1985 Nov;44(11):747–751. doi: 10.1136/ard.44.11.747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Radia M., Furst D. E. Comparison of three pulse methylprednisolone regimens in the treatment of rheumatoid arthritis. J Rheumatol. 1988 Feb;15(2):242–246. [PubMed] [Google Scholar]
  18. Shipley M. E., Bacon P. A., Berry H., Hazleman B. L., Sturrock R. D., Swinson D. R., Williams I. A. Pulsed methylprednisolone in active early rheumatoid disease: a dose-ranging study. Br J Rheumatol. 1988 Jun;27(3):211–214. doi: 10.1093/rheumatology/27.3.211. [DOI] [PubMed] [Google Scholar]
  19. Smith M. D., Ahern M. J., Brooks P. M., Roberts-Thomson P. J. The clinical and immunological effects of pulse methylprednisolone therapy in rheumatoid arthritis. II. Effects on immune and inflammatory indices in peripheral blood. J Rheumatol. 1988 Feb;15(2):233–237. [PubMed] [Google Scholar]
  20. Smith M. D., Ahern M. J., Roberts-Thomson P. J. Pulse steroid therapy in rheumatoid arthritis: can equivalent doses of oral prednisolone give similar clinical results to intravenous methylprednisolone? Ann Rheum Dis. 1988 Jan;47(1):28–33. doi: 10.1136/ard.47.1.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Smith M. D., Bertouch J. V., Smith A. M., Weatherall M., Ahern M. J., Brooks P. M., Roberts-Thomson P. J. The clinical and immunological effects of pulse methylprednisolone therapy in rheumatoid arthritis. I. Clinical effects. J Rheumatol. 1988 Feb;15(2):229–232. [PubMed] [Google Scholar]
  22. Tsang I. K., Patterson C. A., Stein H. B., Robinson H. S., Ford D. K. D-penicillamine in the treatment of rheumatoid arthritis. Arthritis Rheum. 1977 Mar;20(2):666–670. doi: 10.1002/art.1780200205. [DOI] [PubMed] [Google Scholar]
  23. Walters M. T., Cawley M. I. Combined suppressive drug treatment in severe refractory rheumatoid disease: an analysis of the relative effects of parenteral methylprednisolone, cyclophosphamide, and sodium aurothiomalate. Ann Rheum Dis. 1988 Nov;47(11):924–929. doi: 10.1136/ard.47.11.924. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Weiss S., Kisch E. S., Fischel B. Systemic effects of intraarticular administration of triamcinolone hexacetonide. Isr J Med Sci. 1983 Jan;19(1):83–84. [PubMed] [Google Scholar]
  25. Williams I. A., Baylis E. M., Shipley M. E. A double-blind placebo-controlled trial of methylprednisolone pulse therapy in active rheumatoid disease. Lancet. 1982 Jul 31;2(8292):237–240. doi: 10.1016/s0140-6736(82)90323-3. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES