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. 1990 Jun;49(6):396–399. doi: 10.1136/ard.49.6.396

Polyclonal B cell activation in ankylosing spondylitis.

P Barbieri 1, I Olivieri 1, G Benedettini 1, P Marelli 1, M L Ciompi 1, G Pasero 1, M Campa 1
PMCID: PMC1004108  PMID: 2383063

Abstract

The peripheral blood lymphocyte response of patients with ankylosing spondylitis (AS) to several polyclonal B cell activators was investigated. No differences were found in the reactivity to pokeweed mitogen and protein A between patients and controls; in contrast, the peripheral blood lymphocyte response to Staphylococcus aureus strain Cowan I (SAC) was significantly higher in patients with AS than in controls. This responsiveness was not influenced either by the presence of the HLA-B27 antigen or by environmental factors or associated diseases, and it was higher in patients with active AS than in those with inactive disease. The percentage of circulating B cells was normal. The responses to T cell mitogens and the percentages of T cell subpopulations were similar in patients and in controls. The peripheral blood lymphocyte hyperactivity of patients with AS to SAC was associated with an increased in vitro production of immunoglobulins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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