Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1991 Jan;50(1):32–35. doi: 10.1136/ard.50.1.32

C reactive protein and immunoglobulin G in synovial fluid and serum in joint disease.

B Shine 1, J T Bourne 1, F Begum Baig 1, J Dacre 1, D V Doyle 1
PMCID: PMC1004321  PMID: 1704698

Abstract

C reactive protein (CRP) and immunoglobulin G (IgG) were measured in synovial fluid and serum of 72 patients (29 with rheumatoid arthritis (RA), 17 with osteoarthritis, 11 with crystal synovitis, seven with undifferentiated arthritis, and eight with seronegative arthritis). The synovial fluid:serum (SF:S) ratios were compared with those calculated from the SF:S ratios of transferrin, caeruloplasmin, and alpha 2 macroglobulin, using the binomial test within groups and the Mann-Whitney test between groups. In RA synovial fluid CRP concentrations were lower than expected and IgG concentrations higher than expected. In osteoarthritis CRP concentrations were higher than expected. In seronegative arthritis IgG concentrations were raised. The ratio of CRP:IgG was depressed in RA. These findings are consistent with a role for CRP in the inflammatory process of RA, while the CRP:IgG ratio may be of value in the differential diagnosis of joint disease.

Full text

PDF
32

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amos R. S., Constable T. J., Crockson R. A., Crockson A. P., McConkey B. Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes. Br Med J. 1977 Jan 22;1(6055):195–197. doi: 10.1136/bmj.1.6055.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baltz M. L., de Beer F. C., Feinstein A., Munn E. A., Milstein C. P., Fletcher T. C., March J. F., Taylor J., Bruton C., Clamp J. R. Phylogenetic aspects of C-reactive protein and related proteins. Ann N Y Acad Sci. 1982;389:49–75. doi: 10.1111/j.1749-6632.1982.tb22125.x. [DOI] [PubMed] [Google Scholar]
  3. Cecere F., Lessard J., McDuffy S., Pope R. M. Evidence for the local production and utilization of immune reactants in rheumatoid arthritis. Arthritis Rheum. 1982 Nov;25(11):1307–1313. doi: 10.1002/art.1780251106. [DOI] [PubMed] [Google Scholar]
  4. Clague R. B., Moore L. J. IgG and IgM antibody to native type II collagen in rheumatoid arthritis serum and synovial fluid. Evidence for the presence of collagen-anticollagen immune complexes in synovial fluid. Arthritis Rheum. 1984 Dec;27(12):1370–1377. doi: 10.1002/art.1780271207. [DOI] [PubMed] [Google Scholar]
  5. De Beer F. C., Shine B., Pepys M. B. Radiometric ligand binding assay for C-reactive protein. Complexed C-reactive protein is not detectable in acute phase serum. Clin Exp Immunol. 1982 Oct;50(1):231–237. [PMC free article] [PubMed] [Google Scholar]
  6. Farr M., Kendall M. J., Young D. W., Meynell M. J., Hawkins C. F. Assessment of rheumatoid activity based on clinical features and blood and synovial fluid analysis. Ann Rheum Dis. 1976 Apr;35(2):163–167. doi: 10.1136/ard.35.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fiedel B. A. Platelet response to aggregated C-reactive protein: fibrinogen-dependent and independent signals. Immunology. 1988 Jan;63(1):169–170. [PMC free article] [PubMed] [Google Scholar]
  8. Gitlin J. D., Gitlin J. I., Gitlin D. Localizing of C-reactive protein in synovium of patients with rheumatoid arthritis. Arthritis Rheum. 1977 Nov-Dec;20(8):1491–1499. doi: 10.1002/art.1780200808. [DOI] [PubMed] [Google Scholar]
  9. Highton J., Hessian P. A., Palmer D. G. The presence and possible significance of C-reactive protein in rheumatoid inflammation. J Rheumatol. 1985 Oct;12(5):871–875. [PubMed] [Google Scholar]
  10. Ionescu Dorohoi T., Niculescu D., Rusu G., Ponea I. Serum and synovial fluid Ig, C3 and CRP levels in rheumatoid arthritis. Arch Roum Pathol Exp Microbiol. 1981 Oct-Dec;40(4):305–311. [PubMed] [Google Scholar]
  11. Jones V., Taylor P. C., Jacoby R. K., Wallington T. B. Synovial synthesis of rheumatoid factors and immune complex constituents in early arthritis. Ann Rheum Dis. 1984 Apr;43(2):235–239. doi: 10.1136/ard.43.2.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kushner I., Somerville-Volanakis J. Studies of synovial and serum C-reactive protein in experimental arthritis in rabbits. Proc Soc Exp Biol Med. 1973 Jan;142(1):112–114. doi: 10.3181/00379727-142-36969. [DOI] [PubMed] [Google Scholar]
  13. Kushner I., Somerville J. A. Permeability of human synovial membrane to plasma proteins. Relationship to molecular size and inflammation. Arthritis Rheum. 1971 Sep-Oct;14(5):560–570. doi: 10.1002/art.1780140503. [DOI] [PubMed] [Google Scholar]
  14. Laurell C. B. Electroimmuno assay. Scand J Clin Lab Invest Suppl. 1972;124:21–37. doi: 10.3109/00365517209102748. [DOI] [PubMed] [Google Scholar]
  15. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  16. Pepys M. B., Rowe I. F., Baltz M. L. C-reactive protein: binding to lipids and lipoproteins. Int Rev Exp Pathol. 1985;27:83–111. [PubMed] [Google Scholar]
  17. Petersen J., Ingemann-Hansen T., Halkjaer-Kristensen J. S. Spontaneous and induced immunoglobulin secretion by synovial fluid B lymphocytes in rheumatoid arthritis. Ann Rheum Dis. 1984 Apr;43(2):140–145. doi: 10.1136/ard.43.2.140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Robey F. A., Jones K. D., Steinberg A. D. C-reactive protein mediates the solubilization of nuclear DNA by complement in vitro. J Exp Med. 1985 Jun 1;161(6):1344–1356. doi: 10.1084/jem.161.6.1344. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Robey F. A., Jones K. D., Tanaka T., Liu T. Y. Binding of C-reactive protein to chromatin and nucleosome core particles. A possible physiological role of C-reactive protein. J Biol Chem. 1984 Jun 10;259(11):7311–7316. [PubMed] [Google Scholar]
  20. Rowe I. F., Sheldon J., Riches P. G., Keat A. C. Comparative studies of serum and synovial fluid C reactive protein concentrations. Ann Rheum Dis. 1987 Oct;46(10):721–726. doi: 10.1136/ard.46.10.721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Rowe I. F., Soutar A. K., Trayner I. M., Thompson G. R., Pepys M. B. Circulating human C-reactive protein binds very low density lipoproteins. Clin Exp Immunol. 1984 Oct;58(1):237–244. [PMC free article] [PubMed] [Google Scholar]
  22. Rowley M. J., Williamson D. J., Mackay I. R. Evidence for local synthesis of antibodies to denatured collagen in the synovium in rheumatoid arthritis. Arthritis Rheum. 1987 Dec;30(12):1420–1425. doi: 10.1002/art.1780301215. [DOI] [PubMed] [Google Scholar]
  23. Volanakis J. E., Narkates A. J. Interaction of C-reactive protein with artificial phosphatidylcholine bilayers and complement. J Immunol. 1981 May;126(5):1820–1825. [PubMed] [Google Scholar]
  24. Zeller J. M., Landay A. L., Lint T. F., Gewurz H. Aggregated C-reactive protein binds to human polymorphonuclear leukocytes and potentiates Fc receptor-mediated chemiluminescence. J Lab Clin Med. 1986 Dec;108(6):567–576. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES