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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1991 Feb;50(2):87–90. doi: 10.1136/ard.50.2.87

Bacterial antigens in synovial biopsy specimens in yersinia triggered reactive arthritis.

R Merilahti-Palo 1, K O Söderström 1, R Lahesmaa-Rantala 1, K Granfors 1, A Toivanen 1
PMCID: PMC1004343  PMID: 1998396

Abstract

Non-viable structures of Yersinia enterocolitica O:3 were shown at the site of inflammation within mononuclear cells in the synovial membrane of eight out of 10 patients with yersinia triggered reactive arthritis. An avidin-biotin-peroxidase complex method, with a rabbit antiserum specific for Y enterocolitica O:3, was used to visualise yersinia structures. All 13 control samples were negative except for one with non-specific mast cell staining. The findings emphasise the significance of foreign material in the initiation of synovitis in reactive arthritis.

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Selected References

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