Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1991 Feb;50(2):91–94. doi: 10.1136/ard.50.2.91

Intestinal permeability in patients with yersinia triggered reactive arthritis.

R Lahesmaa-Rantala 1, K E Magnusson 1, K Granfors 1, R Leino 1, T Sundqvist 1, A Toivanen 1
PMCID: PMC1004344  PMID: 1998397

Abstract

The passive intestinal permeability of patients with yersinia triggered reactive arthritis was studied using different sized polyethylene glycols (PEGs) contained in a mixture of PEG 400 and PEG 1000. The investigation was carried out at least one year after the onset of yersinia infection, and patients had neither acute gastrointestinal nor joint symptoms. The control groups included patients with uncomplicated yersiniosis as well as healthy subjects who were either HLA-B27 positive or negative. An altered intestinal barrier function to PEG molecules was detected in patients with a history of yersinia infection compared with healthy controls. No significant differences in the permeability were found between patients with or without reactive arthritis, nor was there any association of increased permeability with HLA-B27. The passive permeability of the intestinal mucosa to the larger molecules was increased for an unexpectedly long time after the acute yersinia infection, probably contributing to the perpetuation of joint symptoms in subjects susceptible to a chronic joint disease.

Full text

PDF
91

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bjarnason I., Williams P., Smethurst P., Peters T. J., Levi A. J. Effect of non-steroidal anti-inflammatory drugs and prostaglandins on the permeability of the human small intestine. Gut. 1986 Nov;27(11):1292–1297. doi: 10.1136/gut.27.11.1292. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brewerton D. A. Causes of arthritis. Lancet. 1988 Nov 5;2(8619):1063–1066. doi: 10.1016/s0140-6736(88)90076-1. [DOI] [PubMed] [Google Scholar]
  3. Doube A., Collins A. J. Is the gut intrinsically abnormal in rheumatoid arthritis? Ann Rheum Dis. 1988 Aug;47(8):617–619. doi: 10.1136/ard.47.8.617. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ebringer R. W., Cawdell D. R., Cowling P., Ebringer A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis. 1978 Apr;37(2):146–151. doi: 10.1136/ard.37.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fälth-Magnusson K., Kjellman N. I., Magnusson K. E., Sundqvist T. Intestinal permeability in healthy and allergic children before and after sodium-cromoglycate treatment assessed with different-sized polyethyleneglycols (PEG 400 and PEG 1000). Clin Allergy. 1984 May;14(3):277–286. doi: 10.1111/j.1365-2222.1984.tb02207.x. [DOI] [PubMed] [Google Scholar]
  6. Fälth-Magnusson K., Kjellman N. I., Odelram H., Sundqvist T., Magnusson K. E. Gastrointestinal permeability in children with cow's milk allergy: effect of milk challenge and sodium cromoglycate as assessed with polyethyleneglycols (PEG 400 and PEG 1000). Clin Allergy. 1986 Nov;16(6):543–551. doi: 10.1111/j.1365-2222.1986.tb01993.x. [DOI] [PubMed] [Google Scholar]
  7. Fälth-Magnusson K., Kjellman N. I., Sundqvist T., Magnusson K. E. Gastrointestinal permeability in atopic and non-atopic mothers, assessed with different-sized polyethyleneglycols (PEG 400 and PEG 1000). Clin Allergy. 1985 Nov;15(6):565–570. doi: 10.1111/j.1365-2222.1985.tb02310.x. [DOI] [PubMed] [Google Scholar]
  8. Granfors K., Viljanen M., Tiilikainen A., Toivanen A. Persistence of IgM, IgG, and IgA antibodies to Yersinia in yersinia arthritis. J Infect Dis. 1980 Apr;141(4):424–429. doi: 10.1093/infdis/141.4.424. [DOI] [PubMed] [Google Scholar]
  9. Lahesmaa-Rantala R., Granfors K., Kekomäki R., Toivanen A. Circulating yersinia specific immune complexes after acute yersiniosis: a follow up study of patients with and without reactive arthritis. Ann Rheum Dis. 1987 Feb;46(2):121–126. doi: 10.1136/ard.46.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lahesmaa-Rantala R., Lehtonen O. P., Granfors K., Toivanen A. Avidity of anti-Yersinia antibodies in yersiniosis patients with and without Yersinia-triggered reactive arthritis. Arthritis Rheum. 1987 Oct;30(10):1176–1181. doi: 10.1002/art.1780301015. [DOI] [PubMed] [Google Scholar]
  11. Leirisalo-Repo M., Suoranta H. Ten-year follow-up study of patients with Yersinia arthritis. Arthritis Rheum. 1988 Apr;31(4):533–537. doi: 10.1002/art.1780310410. [DOI] [PubMed] [Google Scholar]
  12. Magnusson K. E., Sundqvist T., Sjödahl R., Tagesson C. Altered intestinal permeability to low-molecular-weight polyethyleneglycols (PEG 400) in patients with Crohn's disease. Acta Chir Scand. 1983;149(3):323–327. [PubMed] [Google Scholar]
  13. Mielants H., Veys E. M., Cuvelier C., De Vos M., Botelberghe L. HLA-B27 related arthritis and bowel inflammation. Part 2. Ileocolonoscopy and bowel histology in patients with HLA-B27 related arthritis. J Rheumatol. 1985 Apr;12(2):294–298. [PubMed] [Google Scholar]
  14. Olaison G., Leandersson P., Sjödahl R., Tagesson C. Intestinal permeability to polyethyleneglycol 600 in Crohn's disease. Peroperative determination in a defined segment of the small intestine. Gut. 1988 Feb;29(2):196–199. doi: 10.1136/gut.29.2.196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Serrander R., Magnusson K. E., Kihlström E., Sundqvist T. Acute yersinia infections in man increase intestinal permeability for low-molecular weight polyethylene glycols (PEG 400). Scand J Infect Dis. 1986;18(5):409–413. doi: 10.3109/00365548609032356. [DOI] [PubMed] [Google Scholar]
  16. Shinebaum R., Neumann V. C., Cooke E. M., Wright V. Comparison of faecal florae in patients with rheumatoid arthritis and controls. Br J Rheumatol. 1987 Oct;26(5):329–333. doi: 10.1093/rheumatology/26.5.329. [DOI] [PubMed] [Google Scholar]
  17. Smith M. D., Gibson R. A., Brooks P. M. Abnormal bowel permeability in ankylosing spondylitis and rheumatoid arthritis. J Rheumatol. 1985 Apr;12(2):299–305. [PubMed] [Google Scholar]
  18. Toivanen A., Lahesmaa-Rantala R., Vuento R., Granfors K. Association of persisting IgA response with yersinia triggered reactive arthritis: a study on 104 patients. Ann Rheum Dis. 1987 Dec;46(12):898–901. doi: 10.1136/ard.46.12.898. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. de Koning J., Heesemann J., Hoogkamp-Korstanje J. A., Festen J. J., Houtman P. M., van Oijen P. L. Yersinia in intestinal biopsy specimens from patients with seronegative spondyloarthropathy: correlation with specific serum IgA antibodies. J Infect Dis. 1989 Jan;159(1):109–112. doi: 10.1093/infdis/159.1.109. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES