Abstract
The natural history of radiological changes in the lumbar spine was evaluated in two groups of middle aged Dutch women selected from the general population. One group (n = 236) had recurrent back pain and the other (n = 241) had never experienced back pain. At the beginning of the study disc degeneration was more common in the group with back pain. Osteoporotic vertebral fractures were equally common in both groups. Nine years later both groups showed an increase in prevalence of disc degeneration and osteoporotic fractures. The strongest predictor for change in disc degeneration was the presence of degeneration at the beginning of the study. The development of disc degeneration for the first time was related to body mass index.
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Selected References
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- Dequeker J. The relationship between osteoporosis and osteoarthritis. Clin Rheum Dis. 1985 Aug;11(2):271–296. [PubMed] [Google Scholar]
- Frymoyer J. W. Back pain and sciatica. N Engl J Med. 1988 Feb 4;318(5):291–300. doi: 10.1056/NEJM198802043180506. [DOI] [PubMed] [Google Scholar]
- Frymoyer J. W., Newberg A., Pope M. H., Wilder D. G., Clements J., MacPherson B. Spine radiographs in patients with low-back pain. An epidemiological study in men. J Bone Joint Surg Am. 1984 Sep;66(7):1048–1055. [PubMed] [Google Scholar]
- Garn S. M., Rohmann C. G., Wagner B. Bone loss as a general phenomenon in man. Fed Proc. 1967 Nov-Dec;26(6):1729–1736. [PubMed] [Google Scholar]
- Horsman A., Simpson M. The measurement of sequential changes in cortical bone geometry. Br J Radiol. 1975 Jun;48(570):471–476. doi: 10.1259/0007-1285-48-570-470. [DOI] [PubMed] [Google Scholar]
- KELLGREN J. H., LAWRENCE J. S. Osteo-arthrosis and disk degeneration in an urban population. Ann Rheum Dis. 1958 Dec;17(4):388–397. doi: 10.1136/ard.17.4.388. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KELLGREN J. H., MOORE R. Generalized osteoarthritis and Heberden's nodes. Br Med J. 1952 Jan 26;1(4751):181–187. doi: 10.1136/bmj.1.4751.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lawrence J. S. Disc degeneration. Its frequency and relationship to symptoms. Ann Rheum Dis. 1969 Mar;28(2):121–138. doi: 10.1136/ard.28.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Liang M., Komaroff A. L. Roentgenograms in primary care patients with acute low back pain: a cost-effectiveness analysis. Arch Intern Med. 1982 Jun;142(6):1108–1112. [PubMed] [Google Scholar]
- Lipson S. J., Muir H. Vertebral osteophyte formation in experimental disc degeneration. Morphologic and proteoglycan changes over time. Arthritis Rheum. 1980 Mar;23(3):319–324. doi: 10.1002/art.1780230309. [DOI] [PubMed] [Google Scholar]
- Miettinen O. Estimability and estimation in case-referent studies. Am J Epidemiol. 1976 Feb;103(2):226–235. doi: 10.1093/oxfordjournals.aje.a112220. [DOI] [PubMed] [Google Scholar]
- Renier J. C., Bernat M., Fallah N. Etude corrélative de l'ostéoporose et de la discarthrose. Fréquence comparée de l'ostéophytose rachidienne et de l'épaisseur du disque intervertébral chez 50 sujets porteurs d'une ostéoporose vérifiée par la biopsie osseuse et chez 50 témoins. Etude de la lordose des 50 ostéoporotiques. Rev Rhum Mal Osteoartic. 1981 Apr;48(4):323–330. [PubMed] [Google Scholar]
- Riggs B. L., Melton L. J., 3rd Involutional osteoporosis. N Engl J Med. 1986 Jun 26;314(26):1676–1686. doi: 10.1056/NEJM198606263142605. [DOI] [PubMed] [Google Scholar]
- Torgerson W. R., Dotter W. E. Comparative roentgenographic study of the asymptomatic and symptomatic lumbar spine. J Bone Joint Surg Am. 1976 Sep;58(6):850–853. [PubMed] [Google Scholar]
- Weintroub S., Papo J., Ashkenazi M., Tardiman R., Weissman S. L., Salama R. Osteoarthritis of the hip and fracture of the proximal end of the femur. Acta Orthop Scand. 1982 Apr;53(2):261–264. doi: 10.3109/17453678208992213. [DOI] [PubMed] [Google Scholar]
