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. 1991 May;50(5):278–283. doi: 10.1136/ard.50.5.278

Correlation of histopathological features of pannus with patterns of damage in different joints in rheumatoid arthritis.

S A Allard 1, K D Muirden 1, R N Maini 1
PMCID: PMC1004410  PMID: 2042980

Abstract

The cartilage-pannus junction has been studied in multiple sections from 23 rheumatoid joints. Changes suggesting a metaplastic reaction of the articular cartilage, termed transitional fibroblastic zone, were commonly found in hips and knees, but were rarely present in metatarsophalangeal joints, in which an invasive pannus with cartilage degradation in close association with inflammatory cells was seen. Thus when multiple sections from rheumatoid joints were examined a transitional fibroblastic zone was found in 1/15 (7%) sections from metatarsophalangeal joints compared with 29/57 (51%) and 15/48 (31%) sections from knee and hip joints respectively. In contrast, an invasive pannus occurred in 11/15 (73%) sections from metatarsophalangeal joints compared with 22/57 (39%) sections from knees and 19/48 (40%) sections from hips. These findings led to the suggestion that this pathological variation between different joints may explain the predominance of erosive change in small joints as compared with joint space narrowing with secondary osteoarthritis found in large joints in rheumatoid arthritis. Inappropriate comparisons between different joints may in part explain the variation in findings of previous histopathological studies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allard S. A., Bayliss M. T., Maini R. N. The synovium-cartilage junction of the normal human knee. Implications for joint destruction and repair. Arthritis Rheum. 1990 Aug;33(8):1170–1179. doi: 10.1002/art.1780330818. [DOI] [PubMed] [Google Scholar]
  2. Allard S. A., Muirden K. D., Camplejohn K. L., Maini R. N. Chondrocyte-derived cells and matrix at the rheumatoid cartilage-pannus junction identified with monoclonal antibodies. Rheumatol Int. 1987;7(4):153–159. doi: 10.1007/BF00270363. [DOI] [PubMed] [Google Scholar]
  3. Barrie H. J. Histologic changes in rheumatoid disease of the metacarpal and metatarsal heads as seen in surgical material. J Rheumatol. 1981 Mar-Apr;8(2):246–257. [PubMed] [Google Scholar]
  4. Bromley M., Woolley D. E. Histopathology of the rheumatoid lesion. Identification of cell types at sites of cartilage erosion. Arthritis Rheum. 1984 Aug;27(8):857–863. doi: 10.1002/art.1780270804. [DOI] [PubMed] [Google Scholar]
  5. Cooke T. D. Rheumatoid arthritis pannus: true or false? Arthritis Rheum. 1985 Oct;28(10):1195–1198. doi: 10.1002/art.1780281021. [DOI] [PubMed] [Google Scholar]
  6. Dingle J. T. The effect of synovial catabolin on cartilage synthetic activity. Connect Tissue Res. 1984;12(3-4):277–286. doi: 10.3109/03008208409013690. [DOI] [PubMed] [Google Scholar]
  7. Fassbender H. G., Simmling-Annefeld M. The potential aggressiveness of synovial tissue in rheumatoid arthritis. J Pathol. 1983 Mar;139(3):399–406. doi: 10.1002/path.1711390314. [DOI] [PubMed] [Google Scholar]
  8. Fell H. B., Jubb R. W. The effect of synovial tissue on the breakdown of articular cartilage in organ culture. Arthritis Rheum. 1977 Sep-Oct;20(7):1359–1371. doi: 10.1002/art.1780200710. [DOI] [PubMed] [Google Scholar]
  9. Kiviranta I., Jurvelin J., Tammi M., Sämänen A. M., Helminen H. J. Weight bearing controls glycosaminoglycan concentration and articular cartilage thickness in the knee joints of young beagle dogs. Arthritis Rheum. 1987 Jul;30(7):801–809. doi: 10.1002/art.1780300710. [DOI] [PubMed] [Google Scholar]
  10. Klareskog L., Johnell O., Hulth A. Expression of HLA-DR and HLA-DQ antigens on cells within the cartilage-pannus junction in rheumatoid arthritis. Rheumatol Int. 1984;4 (Suppl):11–15. doi: 10.1007/BF00541273. [DOI] [PubMed] [Google Scholar]
  11. Klareskog L., Johnell O. Induced expression of class II transplantation antigens in the cartilage-pannus junction in RA: chronic synovitis as a model system for aberrant T-lymphocyte activation. Br J Rheumatol. 1988;27 (Suppl 2):141–149. doi: 10.1093/rheumatology/xxvii.suppl_2.141. [DOI] [PubMed] [Google Scholar]
  12. Kobayashi I., Ziff M. Electron microscopic studies of the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum. 1975 Sep-Oct;18(5):475–483. doi: 10.1002/art.1780180507. [DOI] [PubMed] [Google Scholar]
  13. Mills K. Pathology of the knee joint in rheumatoid arthritis. A contribution to the understanding of synovectomy. J Bone Joint Surg Br. 1970 Nov;52(4):746–756. [PubMed] [Google Scholar]
  14. Mitrovic D. The mechanism of cartilage destruction in rheumatoid arthritis. Arthritis Rheum. 1985 Oct;28(10):1192–1195. doi: 10.1002/art.1780281020. [DOI] [PubMed] [Google Scholar]
  15. Rosenberg L. Chemical basis for the histological use of safranin O in the study of articular cartilage. J Bone Joint Surg Am. 1971 Jan;53(1):69–82. [PubMed] [Google Scholar]
  16. Salisbury A. K., Duke O., Poulter L. W. Macrophage-like cells of the pannus area in rheumatoid arthritic joints. Scand J Rheumatol. 1987;16(4):263–272. doi: 10.3109/03009748709102927. [DOI] [PubMed] [Google Scholar]
  17. Shiozawa S., Shiozawa K., Fujita T. Morphologic observations in the early phase of the cartilage-pannus junction. Light and electron microscopic studies of active cellular pannus. Arthritis Rheum. 1983 Apr;26(4):472–478. doi: 10.1002/art.1780260404. [DOI] [PubMed] [Google Scholar]
  18. Takasugi S., Inoue H. Pannus tissue at the cartilage-synovium junction in rheumatoid arthritis. Acta Med Okayama. 1988 Apr;42(2):83–95. doi: 10.18926/AMO/31016. [DOI] [PubMed] [Google Scholar]
  19. Tateishi H. Ultrastructure of synovio-cartilage junction in rheumatoid arthritis. Kobe J Med Sci. 1973 Jun;19(2):51–66. [PubMed] [Google Scholar]
  20. Thompson A. M., Stockwell R. A. An ultrastructural study of the marginal transitional zone in the rabbit knee joint. J Anat. 1983 Jun;136(Pt 4):701–713. [PMC free article] [PubMed] [Google Scholar]
  21. Vogel K. G., Koob T. J. Structural specialization in tendons under compression. Int Rev Cytol. 1989;115:267–293. doi: 10.1016/s0074-7696(08)60632-4. [DOI] [PubMed] [Google Scholar]
  22. Vogel K. G., Thonar E. J. Keratan sulfate is a component of proteoglycans in the compressed region of adult bovine flexor tendon. J Orthop Res. 1988;6(3):434–442. doi: 10.1002/jor.1100060315. [DOI] [PubMed] [Google Scholar]
  23. Woolley D. E., Crossley M. J., Evanson J. M. Collagenase at sites of cartilage erosion in the rheumatoid joint. Arthritis Rheum. 1977 Jul-Aug;20(6):1231–1239. doi: 10.1002/art.1780200612. [DOI] [PubMed] [Google Scholar]
  24. Ziff M. Factors involved in cartilage injury. J Rheumatol Suppl. 1983 Dec;11:13–25. [PubMed] [Google Scholar]

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