Abstract
Numbers of IgA producing cells in peripheral blood were determined by the enzyme linked immunospot (ELISPOT) technique in 15 patients with inflammatory arthritides receiving sulphasalazine treatment. The numbers of IgA producing cells decreased significantly after the first three weeks of treatment. In 11 of the patients this decrease persisted, whereas a subsequent increase was seen in the four others; in two of these latter patients this increase coincided with a temporary withdrawal of the sulphasalazine treatment. A reduction of serum concentrations of IgA and haptoglobin was seen after three months' treatment. Eleven of the patients had a subjective improvement in their joint disease during the first three months of treatment. Analysis of circulating cells committed for IgA secretion may constitute one way of assessing gut associated immunity indirectly, and the present data suggest that sulphasalazine has a rapid effect on lymphocytes possibly originating from the gut and that such an effect precedes improvement in laboratory parameters and clinical symptoms in arthritic diseases.
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Selected References
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- Arnett F. C., Edworthy S. M., Bloch D. A., McShane D. J., Fries J. F., Cooper N. S., Healey L. A., Kaplan S. R., Liang M. H., Luthra H. S. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988 Mar;31(3):315–324. doi: 10.1002/art.1780310302. [DOI] [PubMed] [Google Scholar]
- Bax D. E., Amos R. S. Sulphasalazine: a safe, effective agent for prolonged control of rheumatoid arthritis. A comparison with sodium aurothiomalate. Ann Rheum Dis. 1985 Mar;44(3):194–198. doi: 10.1136/ard.44.3.194. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Collado A., Sanmarti R., Bielsa I., Castel T., Kanterewicz E., Cañete J. D., Brancós M. A., Rotes-Querol J. Immunoglobulin A in the skin of patients with ankylosing spondylitis. Ann Rheum Dis. 1988 Dec;47(12):1004–1007. doi: 10.1136/ard.47.12.1004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cowling P., Ebringer R., Ebringer A. Association of inflammation with raised serum IgA in ankylosing spondylitis. Ann Rheum Dis. 1980 Dec;39(6):545–549. doi: 10.1136/ard.39.6.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cuvelier C., Barbatis C., Mielants H., De Vos M., Roels H., Veys E. Histopathology of intestinal inflammation related to reactive arthritis. Gut. 1987 Apr;28(4):394–401. doi: 10.1136/gut.28.4.394. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Czerkinsky C. C., Tarkowski A., Nilsson L. A., Ouchterlony O., Nygren H., Gretzer C. Reverse enzyme-linked immunospot assay (RELISPOT) for the detection of cells secreting immunoreactive substances. J Immunol Methods. 1984 Sep 4;72(2):489–496. doi: 10.1016/0022-1759(84)90017-6. [DOI] [PubMed] [Google Scholar]
- Delacroix D. L., Elkom K. B., Geubel A. P., Hodgson H. F., Dive C., Vaerman J. P. Changes in size, subclass, and metabolic properties of serum immunoglobulin A in liver diseases and in other diseases with high serum immunoglobulin A. J Clin Invest. 1983 Feb;71(2):358–367. doi: 10.1172/JCI110777. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dougados M., Boumier P., Amor B. Sulphasalazine in ankylosing spondylitis: a double blind controlled study in 60 patients. Br Med J (Clin Res Ed) 1986 Oct 11;293(6552):911–914. doi: 10.1136/bmj.293.6552.911. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ebringer R. W., Cawdell D. R., Cowling P., Ebringer A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis. 1978 Apr;37(2):146–151. doi: 10.1136/ard.37.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Feltelius N., Hällgren R. Circulating inhibitor bound elastase in patients with ankylosing spondylitis and rheumatoid arthritis and the influence of sulphasalazine treatment. Ann Rheum Dis. 1988 Jan;47(1):10–14. doi: 10.1136/ard.47.1.10. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Feltelius N., Hällgren R., Sjöberg O. T lymphocytes in ankylosing spondylitis and the influence of sulphasalazine treatment. Clin Rheumatol. 1987 Dec;6(4):545–552. doi: 10.1007/BF02330592. [DOI] [PubMed] [Google Scholar]
- Feltelius N., Hällgren R. Sulphasalazine in ankylosing spondylitis. Ann Rheum Dis. 1986 May;45(5):396–399. doi: 10.1136/ard.45.5.396. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kutteh W. H., Prince S. J., Mestecky J. Tissue origins of human polymeric and monomeric IgA. J Immunol. 1982 Feb;128(2):990–995. [PubMed] [Google Scholar]
- Mestecky J., McGhee J. R. Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv Immunol. 1987;40:153–245. doi: 10.1016/s0065-2776(08)60240-0. [DOI] [PubMed] [Google Scholar]
- Nissilä M., Lehtinen K., Leirisalo-Repo M., Luukkainen R., Mutru O., Yli-Kerttula U. Sulfasalazine in the treatment of ankylosing spondylitis. A twenty-six-week, placebo-controlled clinical trial. Arthritis Rheum. 1988 Sep;31(9):1111–1116. doi: 10.1002/art.1780310905. [DOI] [PubMed] [Google Scholar]
- Peeters A. J., van den Wall Bake A. W., van Dalsen A. D., Westedt M. L. Relation of microscopic haematuria in ankylosing spondylitis to circulating IgA containing immune complexes. Ann Rheum Dis. 1988 Aug;47(8):645–647. doi: 10.1136/ard.47.8.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Segal A. W., Isenberg D. A., Hajirousou V., Tolfree S., Clark J., Snaith M. L. Preliminary evidence for gut involvement in the pathogenesis of rheumatoid arthritis? Br J Rheumatol. 1986 May;25(2):162–166. doi: 10.1093/rheumatology/25.2.162. [DOI] [PubMed] [Google Scholar]
- Trull A., Ebringer A., Panayi G., Ebringer R., James D. C. HLA-B27 and the immune response to enterobacterial antigens in ankylosing spondylitis. Clin Exp Immunol. 1984 Jan;55(1):74–80. [PMC free article] [PubMed] [Google Scholar]