Abstract
The effect of serum and synovial fluid obtained from six healthy subjects and from 12 patients with gout, six with rheumatoid arthritis and 18 with calcium pyrophosphate dihydrate arthropathy (CPPD) on the rate of in vitro urate crystal formation was measured. Gouty and normal serum produced similar results. Gouty synovial fluids promoted urate crystal formation significantly more than did rheumatoid or CPPD fluids. The promotion of urate crystal formation by gouty synovial fluid was not due to native urate crystals nor to an effect on the level of urate supersaturation. The development of gout in some, but not other, hyperuricaemic subjects may relate to the presence of promoters (or relative lack of inhibitors) of urate crystal formation in the group who develop gout.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Burt H. M., Dutt Y. C. Growth of monosodium urate monohydrate crystals: effect of cartilage and synovial fluid components on in vitro growth rates. Ann Rheum Dis. 1986 Oct;45(10):858–864. doi: 10.1136/ard.45.10.858. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fiddis R. W., Vlachos N., Calvert P. D. Studies of urate crystallisation in relation to gout. Ann Rheum Dis. 1983 Aug;42 (Suppl 1):12–15. doi: 10.1136/ard.42.suppl_1.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Katz W. A., Schubert M. The interaction of monosodium urate with connective tissue components. J Clin Invest. 1970 Oct;49(10):1783–1789. doi: 10.1172/JCI106396. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Perl-Treves D., Addadi L. A structural approach to pathological crystallizations. Gout: the possible role of albumin in sodium urate crystallization. Proc R Soc Lond B Biol Sci. 1988 Nov 22;235(1279):145–159. doi: 10.1098/rspb.1988.0069. [DOI] [PubMed] [Google Scholar]
- Tak H. K., Cooper S. M., Wilcox W. R. Studies on the nucleation of monosodium urate at 37 degrees c. Arthritis Rheum. 1980 May;23(5):574–580. doi: 10.1002/art.1780230509. [DOI] [PubMed] [Google Scholar]
- Wilcox W. R., Khalaf A. A. Nucleation of monosodium urate crystals. Ann Rheum Dis. 1975 Aug;34(4):332–339. doi: 10.1136/ard.34.4.332. [DOI] [PMC free article] [PubMed] [Google Scholar]