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. 1991 Sep;50(9):607–610. doi: 10.1136/ard.50.9.607

Reduction in IgG galactose in juvenile and adult onset rheumatoid arthritis measured by a lectin binding method and its relation to rheumatoid factor.

N Sumar 1, D A Isenberg 1, K B Bodman 1, A Soltys 1, A Young 1, A M Leak 1, J Round 1, F C Hay 1, I M Roitt 1
PMCID: PMC1004502  PMID: 1929582

Abstract

Glycosylation changes in patients with juvenile chronic and adult onset rheumatoid arthritis have been studied using a novel binding method. Both these major types of arthritis showed decreased galactosylation of serum IgG, which confirms earlier studies using a different, more complex chemical method. No significant correlation between serum IgG, IgM, and IgA rheumatoid factors and age corrected G(o) (percentage of oligosaccharide chains lacking galactose) was found. The possibility that the less glycosylated IgG is preferentially confined to circulating IgM/IgG immune complexes cannot be excluded, however.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Balogh Z., Merétey K., Falus A., Bozsóky S. Serological abnormalities in juvenile chronic arthritis: a review of 46 cases. Ann Rheum Dis. 1980 Apr;39(2):129–134. doi: 10.1136/ard.39.2.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bianco N. E., Panush R. S., Stillman J. S., Schur P. H. Immunologic studies of juvenile rheumatoid arthritis. Arthritis Rheum. 1971 Nov-Dec;14(6):685–696. doi: 10.1002/art.1780140603. [DOI] [PubMed] [Google Scholar]
  3. Leatherbarrow R. J., Rademacher T. W., Dwek R. A., Woof J. M., Clark A., Burton D. R., Richardson N., Feinstein A. Effector functions of a monoclonal aglycosylated mouse IgG2a: binding and activation of complement component C1 and interaction with human monocyte Fc receptor. Mol Immunol. 1985 Apr;22(4):407–415. doi: 10.1016/0161-5890(85)90125-7. [DOI] [PubMed] [Google Scholar]
  4. Magsaam J., Ferjencik P., Tempels M., Dippell J. A new method for the detection of hidden IgM rheumatoid factor in patients with juvenile rheumatoid arthritis. J Rheumatol. 1987 Oct;14(5):964–967. [PubMed] [Google Scholar]
  5. Moore T. L., Dorner R. W., Alexander R. L., Osborn T. G. Enzyme linked (ELISA) immunoabsorbent assay for the detection of hidden 19S IgM rheumatoid factors in juvenile rheumatoid arthritis. J Rheumatol. 1988 Jan;15(1):87–90. [PubMed] [Google Scholar]
  6. Nose M., Wigzell H. Biological significance of carbohydrate chains on monoclonal antibodies. Proc Natl Acad Sci U S A. 1983 Nov;80(21):6632–6636. doi: 10.1073/pnas.80.21.6632. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Parekh R. B., Dwek R. A., Sutton B. J., Fernandes D. L., Leung A., Stanworth D., Rademacher T. W., Mizuochi T., Taniguchi T., Matsuta K. Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature. 1985 Aug 1;316(6027):452–457. doi: 10.1038/316452a0. [DOI] [PubMed] [Google Scholar]
  8. Parekh R. B., Roitt I. M., Isenberg D. A., Dwek R. A., Ansell B. M., Rademacher T. W. Galactosylation of IgG associated oligosaccharides: reduction in patients with adult and juvenile onset rheumatoid arthritis and relation to disease activity. Lancet. 1988 Apr 30;1(8592):966–969. doi: 10.1016/s0140-6736(88)91781-3. [DOI] [PubMed] [Google Scholar]
  9. Parekh R., Roitt I., Isenberg D., Dwek R., Rademacher T. Age-related galactosylation of the N-linked oligosaccharides of human serum IgG. J Exp Med. 1988 May 1;167(5):1731–1736. doi: 10.1084/jem.167.5.1731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sumar N., Bodman K. B., Rademacher T. W., Dwek R. A., Williams P., Parekh R. B., Edge J., Rook G. A., Isenberg D. A., Hay F. C. Analysis of glycosylation changes in IgG using lectins. J Immunol Methods. 1990 Jul 20;131(1):127–136. doi: 10.1016/0022-1759(90)90242-n. [DOI] [PubMed] [Google Scholar]
  11. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]

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