Table 4.

Ratios of quantified AQP transcript levels in the temporal cortex as compared to the hippocampal formation differ with age. The average expression (AveExpr) levels were determined by averaging the RNAseq levels for all probes used for a given gene. t-values represent the test statistic associated with the comparison of means using two-sample t-tests, with positive values indicating a larger average RNAseq in the cortical region as compared to the hippocampus. P values were adjusted (Adj P) for multiple tests using the Bonferroni correction, with significant differences indicated by values p < 0.05.

(i) C	Gene	logFC	AveExpr	t	p Value	adj. p Val
Higher expression
	AQP11	1.4622	−0.1312	3.4391	8 × 10−4	0.0074
Lower expression
	AQP3	−1.2113	0.2854	−3.3457	0.0011	0.0074
	AQP10	−1.2381	0.2891	−3.0671	0.0027	0.0119
No significant difference
	AQP9	1.0602	0.1916	2.3150	0.0225	0.0732
	AQP4	0.7552	0.0305	1.9340	0.0558	0.1209
	AQP0	−0.9250	0.0776	−1.9335	0.0558	0.1209
	AQP2	−0.5220	0.2462	−1.1253	0.263	0.4884
	AQP7	0.2543	0.2040	0.5980	0.5511	0.8955
	AQP8	−0.1370	0.2422	−0.3624	0.7178	0.9279
	AQP1	−0.0974	−0.2480	−0.3323	0.7403	0.9279
	AQP5	0.1005	−0.0021	0.2461	0.8061	0.9279
	AQP12	−0.0745	0.2901	−0.1134	0.9099	0.9279
	AQP6	−0.0418	−0.2175	−0.0908	0.9279	0.9279
(ii) AC	Gene	logFC	AveExpr	t	p Value	adj. p Val
Higher expression
	AQP11	0.7296	−0.1312	3.6732	4 × 10−4	0.001
Lower expression
	AQP1	−1.7035	−0.2480	−12.435	<0.001	<0.001
	AQP3	−1.9022	0.2854	−11.247	<0.001	<0.001
	AQP4	−1.4108	0.0305	−7.7335	<0.001	<0.001
	AQP9	−1.0480	0.1916	−4.8983	<0.001	<0.001
	AQP5	−0.4470	−0.0021	−2.3440	0.0209	0.0454
No significant difference
	AQP10	−0.3690	0.2891	−1.9567	0.053	0.0984
	AQP8	0.2502	0.2422	1.4164	0.1596	0.2227
	AQP12	−0.4251	0.2901	−1.3858	0.1687	0.2227
	AQP2	−0.2985	0.2462	−1.3772	0.1713	0.2227
	AQP0	−0.2390	0.0776	−1.0695	0.2873	0.3395
	AQP6	−0.2083	−0.2175	−0.9685	0.335	0.3629
	AQP7	−0.1479	0.2040	−0.7444	0.4583	0.4583