Table 1.

Gq-coupled receptors that mediate anti-inflammatory and antidepressant activity.

Receptor	Citations for Expression by Microglia	Citations for Gq-PLC-PKC Coupling	Citations for Inflammatory Cytokines Decrease	Citation for Antidepressant Activity
Cannabinoid CBR2	[146,153]	[147,161]	[148,149,161]	[144,162]
Opioid μ-receptor	[103,163]	[164]	[165]	[166,167,168]
Serotonin 5HT2B	[101,102]	[169,170,171]	[101,102]	[172,173,174]

Literature citations for the expression of the cannabinoid receptor CBR2, the opioid μ receptor, and the serotonin receptor 5HT2B by microglia cells. Agonists at these receptors activate phospholipase-C (PLC) and protein kinase-C (PKC), which results in inhibition of brain inflammation and improvement of depression symptoms.