Abstract
Paf-acether (paf) is a naturally occurring phospholipid involved in inflammatory processes. The presence of paf, its precursor lyso paf, and lipo-paf has been determined in blood and synovial fluid from 13 patients with rheumatoid arthritis (RA), 11 with spondylarthropathies, eight with other inflammatory rheumatisms, 13 with chondrocalcinosis, 15 with osteoarthritis, and also in blood from nine healthy subjects. Paf and lipo-paf were measured by rabbit platelet aggregation after isolation by high performance liquid chromatography, whereas lyso paf was first chemically acetylated to give paf. Lipo-paf in blood was higher in patients than in controls; lipo-paf concentrations in blood and in synovial fluid were significantly higher in rheumatoid arthritis than in osteoarthritis and chondrocalcinosis. By contrast, paf and lyso paf reached their lower values in rheumatoid arthritis. The amounts of lipid mediators were not correlated with biological parameters of inflammation. Lipo-paf, which is considered as a storage form of paf, may be the important form of paf in active inflammatory rheumatism.
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Selected References
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- Arnett F. C., Edworthy S. M., Bloch D. A., McShane D. J., Fries J. F., Cooper N. S., Healey L. A., Kaplan S. R., Liang M. H., Luthra H. S. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988 Mar;31(3):315–324. doi: 10.1002/art.1780310302. [DOI] [PubMed] [Google Scholar]
- Benveniste J., Le Couedic J. P., Kamoun P. Letter: Aggregation of human platelets by platelet-activating factor. Lancet. 1975 Feb 8;1(7902):344–345. doi: 10.1016/s0140-6736(75)91264-7. [DOI] [PubMed] [Google Scholar]
- Benveniste J., Le Couedic J. P., Polonsky J., Tence M. Structural analysis of purified platelet-activating factor by lipases. Nature. 1977 Sep 8;269(5624):170–171. doi: 10.1038/269170a0. [DOI] [PubMed] [Google Scholar]
- Benveniste J., Nunez D., Duriez P., Korth R., Bidault J., Fruchart J. C. Preformed PAF-acether and lyso PAF-acether are bound to blood lipoproteins. FEBS Lett. 1988 Jan 4;226(2):371–376. doi: 10.1016/0014-5793(88)81456-x. [DOI] [PubMed] [Google Scholar]
- Benveniste J., Tencé M., Varenne P., Bidault J., Boullet C., Polonsky J. Semi-synthèse et structure proposée du facteur activant les plaquettes (P.A.F.): PAF-acether, un alkyl ether analogue de la lysophosphatidylcholine. C R Seances Acad Sci D. 1979 Nov 26;289(14):1037–1040. [PubMed] [Google Scholar]
- Czarnetzki B. M., Benveniste J. Effect of 1-O-octadecyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF-acether) on leukocytes I. Analysis of the in vitro migration of human neutrophils. Chem Phys Lipids. 1981 Dec;29(4):317–326. doi: 10.1016/0009-3084(81)90065-7. [DOI] [PubMed] [Google Scholar]
- Dayer J. M., de Rochemonteix B., Burrus B., Demczuk S., Dinarello C. A. Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells. J Clin Invest. 1986 Feb;77(2):645–648. doi: 10.1172/JCI112350. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Demopoulos C. A., Pinckard R. N., Hanahan D. J. Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators). J Biol Chem. 1979 Oct 10;254(19):9355–9358. [PubMed] [Google Scholar]
- Henderson B., Pettipher E. R., Higgs G. A. Mediators of rheumatoid arthritis. Br Med Bull. 1987 Apr;43(2):415–428. doi: 10.1093/oxfordjournals.bmb.a072191. [DOI] [PubMed] [Google Scholar]
- Pettipher E. R., Higgs G. A., Henderson B. PAF-acether in chronic arthritis. Agents Actions. 1987 Jun;21(1-2):98–103. doi: 10.1007/BF01974929. [DOI] [PubMed] [Google Scholar]
- Polonsky J., Tencé M., Varenne P., Das B. C., Lunel J., Benveniste J. Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl platelet-activating factor, from leukocytes: chemical ionization mass spectrometry of phospholipids. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7019–7023. doi: 10.1073/pnas.77.12.7019. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Salem P., Deryckx S., Dulioust A., Vivier E., Denizot Y., Damais C., Dinarello C. A., Thomas Y. Immunoregulatory functions of paf-acether. IV. Enhancement of IL-1 production by muramyl dipeptide-stimulated monocytes. J Immunol. 1990 Feb 15;144(4):1338–1344. [PubMed] [Google Scholar]
- Stenson W. F. Platelet-activating factor and inflammatory bowel disease. Gastroenterology. 1988 Nov;95(5):1416–1419. doi: 10.1016/0016-5085(88)90383-6. [DOI] [PubMed] [Google Scholar]
- Tencé V., Polonsky J., Le Couedic J. P., Benveniste M. J. Release, purification, and characterization of platelet-activating factor (PAF). Biochimie. 1980;62(4):251–259. doi: 10.1016/s0300-9084(80)80399-3. [DOI] [PubMed] [Google Scholar]