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Effects of AKI surgery and metformin on renal structure and function. (A) Plasma creatinine concentration (PCr); means ± SEM; n = 4–8 per group. (B,D) Representative H&E staining and statistical analysis; means ± SEM; n = 5 per group. (C) Immunoblotting of Sesn2 with isolated cardiomyocytes from Sesn2f/f or cSesn2−/− mouse hearts.
