Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1992 Jun;51(6):726–730. doi: 10.1136/ard.51.6.726

Effects of ultraviolet irradiation on natural killer cell function in systemic lupus erythematosus.

O Nived 1, I Johansson 1, G Sturfelt 1
PMCID: PMC1004734  PMID: 1616354

Abstract

In vitro irradiation with long wavelength ultraviolet light (UV-A), in clinically relevant dosages, of a natural killer cell line containing cell preparations from 17 control subjects reduced natural killer cell cytotoxicity with the cell line K562 as target. The spontaneous function of natural killer cells from 12 patients with systemic lupus erythematosus (SLE) correlated inversely with the one hour erythrocyte sedimentation rate, but not with glucocorticoid doses. After UV-A exposure, natural killer cells from patients with SLE exert either increased or decreased cytotoxicity, and the direction of change is inversely correlated with the spontaneous natural killer cell function.

Full text

PDF
726

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Becker N. J., Crockett R. S., Valenzeno D. P., Abdou N. I. Effect of in vitro ultraviolet radiation on the binding capacity of anti-DNA and DNA in systemic lupus erythematosus. J Rheumatol. 1989 Jun;16(6):773–776. [PubMed] [Google Scholar]
  2. Cseuz R., Panayi G. S. The inhibition of NK cell function by azathioprine during the treatment of patients with rheumatoid arthritis. Br J Rheumatol. 1990 Oct;29(5):358–362. doi: 10.1093/rheumatology/29.5.358. [DOI] [PubMed] [Google Scholar]
  3. Egan M. L., Mendelsohn S. L., Abo T., Balch C. M. Natural killer cells in systemic lupus erythematosus. Abnormal numbers and functional immaturity of HNK-1+ cells. Arthritis Rheum. 1983 May;26(5):623–629. doi: 10.1002/art.1780260508. [DOI] [PubMed] [Google Scholar]
  4. Elmets C. A., Larson K., Urda G. A., Schacter B. Inhibition of postbinding target cell lysis and of lymphokine-induced enhancement of human natural killer cell activity by in vitro exposure to ultraviolet B radiation. Cell Immunol. 1987 Jan;104(1):47–58. doi: 10.1016/0008-8749(87)90005-0. [DOI] [PubMed] [Google Scholar]
  5. Fitzharris P., Alcocer J., Stephens H. A., Knight R. A., Snaith M. L. Insensitivity to interferon of NK cells from patients with systemic lupus erythematosus. Clin Exp Immunol. 1982 Jan;47(1):110–118. [PMC free article] [PubMed] [Google Scholar]
  6. Goto M., Tanimoto K., Horiuchi Y. Natural cell mediated cytotoxicity in systemic lupus erythematosus: suppression by antilymphocyte antibody. Arthritis Rheum. 1980 Nov;23(11):1274–1281. doi: 10.1002/art.1780231108. [DOI] [PubMed] [Google Scholar]
  7. Herberman R. B., Ortaldo J. R., Djeu J. Y., Holden H. T., Jett J., Lang N. P., Rubinstein M., Pestka S. Role of interferon in regulation of cytotoxicity by natural killer cells and macrophages. Ann N Y Acad Sci. 1980;350:63–71. doi: 10.1111/j.1749-6632.1980.tb20608.x. [DOI] [PubMed] [Google Scholar]
  8. Hersey P., Bradley M., Hasic E., Haran G., Edwards A., McCarthy W. H. Immunological effects of solarium exposure. Lancet. 1983 Mar 12;1(8324):545–548. doi: 10.1016/s0140-6736(83)92808-8. [DOI] [PubMed] [Google Scholar]
  9. Hersey P., MacDonald M., Henderson C., Schibeci S., D'Alessandro G., Pryor M., Wilkinson F. J. Suppression of natural killer cell activity in humans by radiation from solarium lamps depleted of UVB. J Invest Dermatol. 1988 Mar;90(3):305–310. doi: 10.1111/1523-1747.ep12456090. [DOI] [PubMed] [Google Scholar]
  10. Hoffman T. Natural killer funciton in systemic lupus erythematosus. Arthritis Rheum. 1980 Jan;23(1):30–35. doi: 10.1002/art.1780230106. [DOI] [PubMed] [Google Scholar]
  11. Itoh K., Inoue M., Kataoka S., Kumagai K. Differential effect of interferon expression of IgG- and IgM-Fc receptors on human lymphocytes. J Immunol. 1980 Jun;124(6):2589–2595. [PubMed] [Google Scholar]
  12. Kutteh W. H., Koopman W. J., Conley M. E., Egan M. L., Mestecky J. Production of predominantly polymeric IgA by human peripheral blood lymphocytes stimulated in vitro with mitogens. J Exp Med. 1980 Nov 1;152(5):1424–1429. doi: 10.1084/jem.152.5.1424. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lozzio C. B., Lozzio B. B. Cytotoxicity of a factor isolated from human spleen. J Natl Cancer Inst. 1973 Feb;50(2):535–538. doi: 10.1093/jnci/50.2.535. [DOI] [PubMed] [Google Scholar]
  14. Martin L., Chalmers I. M. Photosensitivity to fluorescent light in a patient with systemic lupus erythematosus. J Rheumatol. 1983 Oct;10(5):811–812. [PubMed] [Google Scholar]
  15. Pedersen B. K. Modulation of natural killer cell activity in patients with immune-inflammatory diseases. Dan Med Bull. 1988 Aug;35(4):315–322. [PubMed] [Google Scholar]
  16. Pross H. F., Maroun J. A. The standardization of NK cell assays for use in studies of biological response modifiers. J Immunol Methods. 1984 Mar 30;68(1-2):235–249. doi: 10.1016/0022-1759(84)90154-6. [DOI] [PubMed] [Google Scholar]
  17. Sibbitt W. L., Jr, Froelich C. J., Bankhurst A. D. Abnormal interferon modulation of natural cytotoxicity in systemic lupus erythematosus. Relation to suppressive serum factors. Arthritis Rheum. 1983 Dec;26(12):1452–1459. doi: 10.1002/art.1780261206. [DOI] [PubMed] [Google Scholar]
  18. Silverman S. L., Cathcart E. S. Natural killing in systemic lupus erythematosus: inhibitory effects of serum. Clin Immunol Immunopathol. 1980 Oct;17(2):219–226. doi: 10.1016/0090-1229(80)90090-2. [DOI] [PubMed] [Google Scholar]
  19. Sirianni M. C., Tagliaferri F., Aiuti F. Pathogenesis of the natural killer cell deficiency in AIDS. Immunol Today. 1990 Mar;11(3):81–82. doi: 10.1016/0167-5699(90)90032-5. [DOI] [PubMed] [Google Scholar]
  20. Sturfelt G., Nived O. Clinical inconsistency, benign course and normal employment rates in unselected systemic lupus erythematosus. Clin Exp Rheumatol. 1985 Oct-Dec;3(4):303–310. [PubMed] [Google Scholar]
  21. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
  22. Tartof D., Yung C. W., Curran J. J., Livingston C., Thalji Z. Cells that mediate NK like cytotoxicity are present in the human delayed type hypersensitivity response. Clin Exp Immunol. 1984 Nov;58(2):462–469. [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES