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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1992 Jun;51(6):793–796. doi: 10.1136/ard.51.6.793

Joint hypermobility in adults referred to rheumatology clinics.

A J Bridges 1, E Smith 1, J Reid 1
PMCID: PMC1004749  PMID: 1616366

Abstract

Joint hypermobility is a rarely recognised aetiology for focal or diffuse musculoskeletal symptoms. To assess the occurrence and importance of joint hypermobility in adult patients referred to a rheumatologist, we prospectively evaluated 130 consecutive new patients for joint hypermobility. Twenty women (15%) had joint hypermobility at three or more locations (greater than or equal to 5 points on a 9 point scale). Most patients with joint hypermobility had common musculoskeletal problems as the reason for referral. Two patients referred with a diagnosis of rheumatoid arthritis were correctly reassigned a diagnosis of hypermobility syndrome. Three patients with systemic lupus erythematosus had diffuse joint hypermobility. There was a statistically significant association between diffuse joint hypermobility and osteoarthritis. Most patients (65%) had first degree family members with a history of joint hypermobility. These results show that joint hypermobility is common, familial, found in association with common rheumatic disorders, and statistically associated with osteoarthritis. The findings support the hypothesis that joint hypermobility predisposes to musculoskeletal disorders, especially osteoarthritis.

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Selected References

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  1. Babini S. M., Cocco J. A., Babini J. C., de la Sota M., Arturi A., Marcos J. C. Atlantoaxial subluxation in systemic lupus erythematosus: further evidence of tendinous alterations. J Rheumatol. 1990 Feb;17(2):173–177. [PubMed] [Google Scholar]
  2. Beighton P. H., Horan F. T. Dominant inheritance in familial generalised articular hypermobility. J Bone Joint Surg Br. 1970 Feb;52(1):145–147. [PubMed] [Google Scholar]
  3. Beighton P., Solomon L., Soskolne C. L. Articular mobility in an African population. Ann Rheum Dis. 1973 Sep;32(5):413–418. doi: 10.1136/ard.32.5.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bird H. A., Tribe C. R., Bacon P. A. Joint hypermobility leading to osteoarthrosis and chondrocalcinosis. Ann Rheum Dis. 1978 Jun;37(3):203–211. doi: 10.1136/ard.37.3.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Biro F., Gewanter H. L., Baum J. The hypermobility syndrome. Pediatrics. 1983 Nov;72(5):701–706. [PubMed] [Google Scholar]
  6. Child A. H. Joint hypermobility syndrome: inherited disorder of collagen synthesis. J Rheumatol. 1986 Apr;13(2):239–243. [PubMed] [Google Scholar]
  7. Gedalia A., Person D. A., Brewer E. J., Jr, Giannini E. H. Hypermobility of the joints in juvenile episodic arthritis/arthralgia. J Pediatr. 1985 Dec;107(6):873–876. doi: 10.1016/s0022-3476(85)80178-5. [DOI] [PubMed] [Google Scholar]
  8. Grahame R. 'The hypermobility syndrome'. Ann Rheum Dis. 1990 Mar;49(3):199–200. doi: 10.1136/ard.49.3.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Grahame R., Edwards J. C., Pitcher D., Gabell A., Harvey W. A clinical and echocardiographic study of patients with the hypermobility syndrome. Ann Rheum Dis. 1981 Dec;40(6):541–546. doi: 10.1136/ard.40.6.541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Grahame R. How often, when and how does joint hypermobility lead to osteoarthritis? Br J Rheumatol. 1989 Aug;28(4):320–320. doi: 10.1093/rheumatology/28.4.320. [DOI] [PubMed] [Google Scholar]
  11. Handler C. E., Child A., Light N. D., Dorrance D. E. Mitral valve prolapse, aortic compliance, and skin collagen in joint hypermobility syndrome. Br Heart J. 1985 Nov;54(5):501–508. doi: 10.1136/hrt.54.5.501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Horan F. T., Beighton P. H. Recessive inheritance of generalized joint hypermobility. Rheumatol Rehabil. 1973 Feb;12(1):47–49. doi: 10.1093/rheumatology/12.1.47. [DOI] [PubMed] [Google Scholar]
  13. Jessee E. F., Owen D. S., Jr, Sagar K. B. The benign hypermobile joint syndrome. Arthritis Rheum. 1980 Sep;23(9):1053–1056. doi: 10.1002/art.1780230914. [DOI] [PubMed] [Google Scholar]
  14. Kirk J. A., Ansell B. M., Bywaters E. G. The hypermobility syndrome. Musculoskeletal complaints associated with generalized joint hypermobility. Ann Rheum Dis. 1967 Sep;26(5):419–425. doi: 10.1136/ard.26.5.419. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Larsson L. G., Baum J., Mudholkar G. S. Hypermobility: features and differential incidence between the sexes. Arthritis Rheum. 1987 Dec;30(12):1426–1430. doi: 10.1002/art.1780301216. [DOI] [PubMed] [Google Scholar]
  16. Lewkonia R. M., Ansell B. M. Articular hypermobility simulating chronic rheumatic disease. Arch Dis Child. 1983 Dec;58(12):988–992. doi: 10.1136/adc.58.12.988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Nicholas J. A. Injuries to knee ligaments. Relationship to looseness and tightness in football players. JAMA. 1970 Jun 29;212(13):2236–2239. doi: 10.1001/jama.212.13.2236. [DOI] [PubMed] [Google Scholar]
  18. Ondrasík M., Rybár I., Rus V., Bosák V. Joint hypermobility in primary mitral valve prolapse patients. Clin Rheumatol. 1988 Mar;7(1):69–73. doi: 10.1007/BF02284059. [DOI] [PubMed] [Google Scholar]
  19. Pitcher D., Grahame R. Mitral valve prolapse and joint hypermobility: evidence for a systemic connective tissue abnormality? Ann Rheum Dis. 1982 Aug;41(4):352–354. doi: 10.1136/ard.41.4.352. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Scott D., Bird H., Wright V. Joint laxity leading to osteoarthrosis. Rheumatol Rehabil. 1979 Aug;18(3):167–169. doi: 10.1093/rheumatology/18.3.167. [DOI] [PubMed] [Google Scholar]
  21. Wynne-Davies R. Familial joint laxity. Proc R Soc Med. 1971 Jun;64(6):689–690. [PMC free article] [PubMed] [Google Scholar]

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