Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1992 Jun;51(6):797–802. doi: 10.1136/ard.51.6.797

Aberrant cytokine production from tenosynovium in dialysis associated amyloidosis.

N Miyasaka 1, K Sato 1, Y Kitano 1, M Higaki 1, K Nishioka 1, K Ohta 1
PMCID: PMC1004750  PMID: 1616367

Abstract

Culture supernatants of tenosynovial tissues from patients with carpal tunnel syndrome undergoing chronic haemodialysis contained interleukin (IL) 1-like and IL6-like activity. These culture supernatants also induced active proliferation of rheumatoid synovial cells. Immunohistochemical analysis of teno-synovial tissues showed the accumulation of mononuclear cells bearing CD14 and HLA-DR antigens adjacent to the deposition of amyloid protein (beta 2 microglobulin). These cells also reacted with antibodies to IL1 and IL6 respectively. These data suggest that multiple cytokines, including IL1 and IL6, produced from tenosynovial tissues in patients with dialysis associated amyloidosis might induce the proliferation of synovial cells that, together with deposition of amyloid protein, might cause carpal tunnel syndrome.

Full text

PDF
797

Images in this article

800Image
on p.800
800Image
on p.800
800Image
on p.800

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bardin T., Kuntz D., Zingraff J., Voisin M. C., Zelmar A., Lansaman J. Synovial amyloidosis in patients undergoing long-term hemodialysis. Arthritis Rheum. 1985 Sep;28(9):1052–1058. doi: 10.1002/art.1780280913. [DOI] [PubMed] [Google Scholar]
  2. Bardin T., Zingraff J., Shirahama T., Noel L. H., Droz D., Voisin M. C., Drueke T., Dryll A., Skinner M., Cohen A. S. Hemodialysis-associated amyloidosis and beta-2 microglobulin. Clinical and immunohistochemical study. Am J Med. 1987 Sep;83(3):419–424. doi: 10.1016/0002-9343(87)90750-9. [DOI] [PubMed] [Google Scholar]
  3. Bingel M., Lonnemann G., Shaldon S., Koch K. M., Dinarello C. A. Human interleukin-1 production during hemodialysis. Nephron. 1986;43(3):161–163. doi: 10.1159/000183822. [DOI] [PubMed] [Google Scholar]
  4. Conlon P. J., Grabstein K. H., Alpert A., Prickett K. S., Hopp T. P., Gillis S. Localization of human mononuclear cell interleukin 1. J Immunol. 1987 Jul 1;139(1):98–102. [PubMed] [Google Scholar]
  5. Content J., De Wit L., Poupart P., Opdenakker G., Van Damme J., Billiau A. Induction of a 26-kDa-protein mRNA in human cells treated with an interleukin-1-related, leukocyte-derived factor. Eur J Biochem. 1985 Oct 15;152(2):253–257. doi: 10.1111/j.1432-1033.1985.tb09191.x. [DOI] [PubMed] [Google Scholar]
  6. Dayer J. M., de Rochemonteix B., Burrus B., Demczuk S., Dinarello C. A. Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells. J Clin Invest. 1986 Feb;77(2):645–648. doi: 10.1172/JCI112350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dewhirst F. E., Stashenko P. P., Mole J. E., Tsurumachi T. Purification and partial sequence of human osteoclast-activating factor: identity with interleukin 1 beta. J Immunol. 1985 Oct;135(4):2562–2568. [PubMed] [Google Scholar]
  8. Dinarello C. A., Ikejima T., Warner S. J., Orencole S. F., Lonnemann G., Cannon J. G., Libby P. Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro. J Immunol. 1987 Sep 15;139(6):1902–1910. [PubMed] [Google Scholar]
  9. Dinarello C. A., Koch K. M., Shaldon S. Interleukin-1 and its relevance in patients treated with hemodialysis. Kidney Int Suppl. 1988 Mar;24:S21–S26. [PubMed] [Google Scholar]
  10. Gejyo F., Odani S., Yamada T., Honma N., Saito H., Suzuki Y., Nakagawa Y., Kobayashi H., Maruyama Y., Hirasawa Y. Beta 2-microglobulin: a new form of amyloid protein associated with chronic hemodialysis. Kidney Int. 1986 Sep;30(3):385–390. doi: 10.1038/ki.1986.196. [DOI] [PubMed] [Google Scholar]
  11. Gejyo F., Yamada T., Odani S., Nakagawa Y., Arakawa M., Kunitomo T., Kataoka H., Suzuki M., Hirasawa Y., Shirahama T. A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin. Biochem Biophys Res Commun. 1985 Jun 28;129(3):701–706. doi: 10.1016/0006-291x(85)91948-5. [DOI] [PubMed] [Google Scholar]
  12. Gorevic P. D., Casey T. T., Stone W. J., DiRaimondo C. R., Prelli F. C., Frangione B. Beta-2 microglobulin is an amyloidogenic protein in man. J Clin Invest. 1985 Dec;76(6):2425–2429. doi: 10.1172/JCI112257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Goto M., Sasano M., Yamanaka H., Miyasaka N., Kamatani N., Inoue K., Nishioka K., Miyamoto T. Spontaneous production of an interleukin 1-like factor by cloned rheumatoid synovial cells in long-term culture. J Clin Invest. 1987 Sep;80(3):786–796. doi: 10.1172/JCI113135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hirano T., Taga T., Nakano N., Yasukawa K., Kashiwamura S., Shimizu K., Nakajima K., Pyun K. H., Kishimoto T. Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci U S A. 1985 Aug;82(16):5490–5494. doi: 10.1073/pnas.82.16.5490. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kishimoto T., Hirano T. Molecular regulation of B lymphocyte response. Annu Rev Immunol. 1988;6:485–512. doi: 10.1146/annurev.iy.06.040188.002413. [DOI] [PubMed] [Google Scholar]
  16. Lachman L. B., Dinarello C. A., Llansa N. D., Fidler I. J. Natural and recombinant human interleukin 1-beta is cytotoxic for human melanoma cells. J Immunol. 1986 Apr 15;136(8):3098–3102. [PubMed] [Google Scholar]
  17. Lachman L. B., Hacker M. P., Blyden G. T., Handschumacher R. E. Preparation of lymphocyte-activating factor from continuous murine macrophage cell lines. Cell Immunol. 1977 Dec;34(2):416–419. doi: 10.1016/0008-8749(77)90263-5. [DOI] [PubMed] [Google Scholar]
  18. Matsuda T., Hirano T., Kishimoto T. Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2-dependent cell line and preparation of anti-IL 6 monoclonal antibodies. Eur J Immunol. 1988 Jun;18(6):951–956. doi: 10.1002/eji.1830180618. [DOI] [PubMed] [Google Scholar]
  19. Miyasaka N., Sato K., Goto M., Sasano M., Natsuyama M., Inoue K., Nishioka K. Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients. Possible involvement in joint destruction. Arthritis Rheum. 1988 Apr;31(4):480–486. doi: 10.1002/art.1780310404. [DOI] [PubMed] [Google Scholar]
  20. Miyasaka N., Sato K., Hashimoto J., Kohsaka H., Yamamoto K., Goto M., Inoue K., Matsuda T., Hirano T., Kishimoto T. Constitutive production of interleukin 6/B cell stimulatory factor-2 from inflammatory synovium. Clin Immunol Immunopathol. 1989 Aug;52(2):238–247. doi: 10.1016/0090-1229(89)90175-x. [DOI] [PubMed] [Google Scholar]
  21. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983 Dec 16;65(1-2):55–63. doi: 10.1016/0022-1759(83)90303-4. [DOI] [PubMed] [Google Scholar]
  22. Nakai S., Mizuno K., Kaneta M., Hirai Y. A simple, sensitive bioassay for the detection of interleukin-1 using human melanoma A375 cell line. Biochem Biophys Res Commun. 1988 Aug 15;154(3):1189–1196. doi: 10.1016/0006-291x(88)90266-5. [DOI] [PubMed] [Google Scholar]
  23. Schmidt J. A., Mizel S. B., Cohen D., Green I. Interleukin 1, a potential regulator of fibroblast proliferation. J Immunol. 1982 May;128(5):2177–2182. [PubMed] [Google Scholar]
  24. Schwarz A., Keller F., Seyfert S., Pöll W., Molzahn M., Distler A. Carpal tunnel syndrome: a major complication in long-term hemodialysis patients. Clin Nephrol. 1984 Sep;22(3):133–137. [PubMed] [Google Scholar]
  25. Tanaka K., Ishikawa E., Ohmoto Y., Hirai Y. In vitro production of human interleukin 1 alpha and interleukin 1 beta by peripheral blood mononuclear cells examined by sensitive sandwich enzyme immunoassay. Eur J Immunol. 1987 Oct;17(10):1527–1530. doi: 10.1002/eji.1830171024. [DOI] [PubMed] [Google Scholar]
  26. Warren D. J., Otieno L. S. Carpal tunnel syndrome in patients on intermittent haemodialysis. Postgrad Med J. 1975 Jul;51(597):450–452. doi: 10.1136/pgmj.51.597.450. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES