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. 1992 Jun;51(6):805–807. doi: 10.1136/ard.51.6.805

Histiocytic necrotising lymphadenitis in systemic lupus erythematosus.

M D Litwin 1, B Kirkham 1, D R Henderson 1, S C Milazzo 1
PMCID: PMC1004752  PMID: 1616369

Abstract

Histiocytic necrotising lymphadenitis is the pathognomonic histological appearance of lymph nodes in Kikuchi's disease, a condition characterised by a brief systemic illness and lymphadenopathy. The case is described of a young man, originally diagnosed as having Kikuchi's disease by lymph node histology, who subsequently developed systemic lupus erythematosus with symmetrical polyarthritis, Coombs' positive haemolytic anaemia and haemorrhagic pneumonitis. The case emphasises that a range of diseases is associated with histiocytic necrotising lymphadenitis, belying the unitary impression given by the term Kikuchi's disease.

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Selected References

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  1. Bailey E. M., Klein N. C., Cunha B. A. Kikuchi's disease with liver dysfunction presenting as fever of unknown origin. Lancet. 1989 Oct 21;2(8669):986–986. doi: 10.1016/s0140-6736(89)90997-5. [DOI] [PubMed] [Google Scholar]
  2. Bowness P., Dutoit S. H. Kikuchi's disease as a cause of fever and cervical lymphadenopathy. J Infect. 1988 May;16(3):310–311. doi: 10.1016/s0163-4453(88)97868-1. [DOI] [PubMed] [Google Scholar]
  3. Chan J. K., Wong K. C., Ng C. S. A fatal case of multicentric Kikuchi's histiocytic necrotizing lymphadenitis. Cancer. 1989 May 1;63(9):1856–1862. doi: 10.1002/1097-0142(19900501)63:9<1856::aid-cncr2820630933>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  4. Dorfman R. F., Berry G. J. Kikuchi's histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol. 1988 Nov;5(4):329–345. [PubMed] [Google Scholar]
  5. Eagen J. W., Memoli V. A., Roberts J. L., Matthew G. R., Schwartz M. M., Lewis E. J. Pulmonary hemorrhage in systemic lupus erythematosus. Medicine (Baltimore) 1978 Nov;57(6):545–560. doi: 10.1097/00005792-197811000-00005. [DOI] [PubMed] [Google Scholar]
  6. Kapadia V., Robinson B. A., Angus H. B. Kikuchi's disease presenting as fever of unknown origin. Lancet. 1989 Dec 23;2(8678-8679):1519–1520. doi: 10.1016/s0140-6736(89)92956-5. [DOI] [PubMed] [Google Scholar]
  7. Leatherman J. W., Davies S. F., Hoidal J. R. Alveolar hemorrhage syndromes: diffuse microvascular lung hemorrhage in immune and idiopathic disorders. Medicine (Baltimore) 1984 Nov;63(6):343–361. [PubMed] [Google Scholar]
  8. Lyberatos C. Two more cases of Still's disease and Kikuchi's. J Rheumatol. 1990 Apr;17(4):568–569. [PubMed] [Google Scholar]
  9. Medeiros L. J., Kaynor B., Harris N. L. Lupus lymphadenitis: report of a case with immunohistologic studies on frozen sections. Hum Pathol. 1989 Mar;20(3):295–299. doi: 10.1016/0046-8177(89)90141-x. [DOI] [PubMed] [Google Scholar]
  10. Myers J. L., Katzenstein A. A. Microangiitis in lupus-induced pulmonary hemorrhage. Am J Clin Pathol. 1986 May;85(5):552–556. doi: 10.1093/ajcp/85.5.552. [DOI] [PubMed] [Google Scholar]
  11. Nieman R. B. Diagnosis of Kikuchi's disease. Lancet. 1990 Feb 3;335(8684):295–295. doi: 10.1016/0140-6736(90)90116-m. [DOI] [PubMed] [Google Scholar]
  12. Ohta A., Matsumoto Y., Ohta T., Kaneoka H., Yamaguchi M. Still's disease associated with necrotizing lymphadenitis (Kikuchi's disease): report of 3 cases. J Rheumatol. 1988 Jun;15(6):981–983. [PubMed] [Google Scholar]
  13. Pileri S., Kikuchi M., Helbron D., Lennert K. Histiocytic necrotizing lymphadenitis without granulocytic infiltration. Virchows Arch A Pathol Anat Histol. 1982;395(3):257–271. doi: 10.1007/BF00429352. [DOI] [PubMed] [Google Scholar]
  14. Rudniki C., Kessler E., Zarfati M., Turani H., Bar-Ziv Y., Zahavi I. Kikuchi's necrotizing lymphadenitis: a cause of fever of unknown origin and splenomegaly. Acta Haematol. 1988;79(2):99–102. doi: 10.1159/000205730. [DOI] [PubMed] [Google Scholar]
  15. Wangel A. G., Milton A., Egan J. B. Spontaneous plaque forming cells in the peripheral blood of patients with systemic lupus erythematosus. Clin Exp Immunol. 1982 Jul;49(1):41–49. [PMC free article] [PubMed] [Google Scholar]

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