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. 1992 Jul;51(7):881–884. doi: 10.1136/ard.51.7.881

Pityriasis rosea and discoid eczema: dose related reactions to treatment with gold.

S M Wilkinson 1, A G Smith 1, M J Davis 1, D Mattey 1, P T Dawes 1
PMCID: PMC1004773  PMID: 1385941

Abstract

Sixteen cases of either a pityriasiform or discoid eczematous rash occurring in patients with rheumatoid arthritis receiving treatment with gold (sodium aurothiomalate and auranofin) were studied. The results suggest that this is a dose related, not allergic, reaction to gold. The development of this rash is not an absolute indication to stop treatment with gold. Control can often be effected with potent topical steroids or a reduction in the dose or frequency of treatment with gold.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Caspi D., Tishler M., Yaron M. Association between gold induced skin rash and remission in patients with rheumatoid arthritis. Ann Rheum Dis. 1989 Sep;48(9):730–732. doi: 10.1136/ard.48.9.730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Davis P., Ezeoke A., Munro J., Hobbs J. R., Hughes G. R. Immunological studies on the mechanism of gold hypersensitivity reactions. Br Med J. 1973 Sep 29;3(5882):676–678. doi: 10.1136/bmj.3.5882.676. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Davis P., Hughes G. R. Significance of eosinophilia during gold therapy. Arthritis Rheum. 1974 Nov-Dec;17(6):964–968. doi: 10.1002/art.1780170607. [DOI] [PubMed] [Google Scholar]
  4. Denman E. J., Denman A. M. The lymphocyte transformation test and gold hypersensitivity. Ann Rheum Dis. 1968 Nov;27(6):582–589. doi: 10.1136/ard.27.6.582. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fitzgerald O. M., Barnes L., Woods R., McHugh L., Barry C., O'Loughlin S. Direct immunofluorescence of normal skin in rheumatoid arthritis. Br J Rheumatol. 1985 Nov;24(4):340–345. doi: 10.1093/rheumatology/24.4.340. [DOI] [PubMed] [Google Scholar]
  6. Gibbons R. B. Complications of chrysotherapy: a review of recent studies. Arch Intern Med. 1979 Mar;139(3):343–346. [PubMed] [Google Scholar]
  7. Gottlieb N. L., Smith P. M., Penneys N. S., Smith E. M. Gold concentrations in hair, nail, and skin during chrysotherapy. Arthritis Rheum. 1974 Jan-Feb;17(1):56–62. doi: 10.1002/art.1780170109. [DOI] [PubMed] [Google Scholar]
  8. Grennan D. M., Palmer D. G. Serum IgE concentrations in rheumatoid arthritis: lack of correlation with gold toxicity. Br Med J. 1979 Dec 8;2(6203):1477–1478. doi: 10.1136/bmj.2.6203.1477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Penneys N. S., Ackerman A. B., Gottlieb N. L. Gold dermatitis. A clinical and histopathological study. Arch Dermatol. 1974 Mar;109(3):372–376. doi: 10.1001/archderm.109.3.372. [DOI] [PubMed] [Google Scholar]
  10. Penneys N. S., Ziboh V., Gottlieb N. L., Katz S. Inhibition of prostaglandin synthesis and human epidermal enzymes by aurothiomalate in vitro: possible actions of gold in pemphigus. J Invest Dermatol. 1974 Oct;63(4):356–361. doi: 10.1111/1523-1747.ep12680840. [DOI] [PubMed] [Google Scholar]
  11. Wilkin J. K., Kirkendall W. M. Pityriasis rosea-like rash from captopril. Arch Dermatol. 1982 Mar;118(3):186–187. [PubMed] [Google Scholar]
  12. Wojnarowska F., Bhogal B., Black M. M. The significance of an IgM band at the dermo-epidermal junction. J Cutan Pathol. 1986 Oct;13(5):359–362. doi: 10.1111/j.1600-0560.1986.tb00470.x. [DOI] [PubMed] [Google Scholar]

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